DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF749

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001018855.2	Gene:	ZNF749 / 388567	HGNCID:	32783	Length:	778	Species:	Homo sapiens

Alignment Length:	633	Identity:	147/633 - (23%)
Similarity:	222/633 - (35%)	Gaps:	191/633 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ISSQTCRVCLE-------------TH-ETNLYV----HDEIKYNDLKLELWQLLEAVSKLKWTWT 56
            :.:|.|::|..             || |..||.    ||..:...::.:|.:..|      |..:
Human    81 LKAQPCKMCSSILKDILHLAEHDGTHPEQGLYTCAAEHDLHQKEQIREKLTRSDE------WRPS 139

  Fly    57 DPNLPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQEVAAKPDEVHVDVVE----LIDQDD 117
            ..|...|         :|...|.........|..:...||:|.....:::.|..:    ..:|:|
Human   140 FVNHSAH---------VGERNFTCTQGGKDFTASSDLLQQQVLNSGWKLYRDTQDGEAFQGEQND 195

  Fly   118 VVS------------MAQYLSTSFAEQHVEMEE-----KYGDQDCSAFTSDVGEEPLYASE---- 161
            ..|            :.::..|...|:..|..|     :|.........:..||.|...:|
Human   196 FNSSQGGKDFCHQHGLFEHQKTHNGERPYEFSECGELFRYNSNLIKYQQNHAGERPYEGTEYGKT 260

  Fly   162 --------DRDDEPEDSFQLKPRPDEIENRE-LSRPSQ----------------LGSRLNHSANF 201
                    .......:.| |..|.|.||::| ||||:.                :|.:..|:...
Human   261 FIRKSNLVQHQKIHSEGF-LSKRSDPIEHQEILSRPTPYECTQCGKAFLTQAHLVGHQKTHTGEQ 324

  Fly   202 IYKCAVCPRVFAKSESLTRH-----------FSQAHKLTADVAAM-KLANESCGTGLLTCEHCPR 254
            .|:|..|.:.|..:..|.||           .|:..||..|...: :......|.....|..|.:
Human   325 PYECNKCGKFFMYNSKLIRHQKVHTGERRYECSECGKLFMDSFTLGRHQRVHTGERPFECSICGK 389

  Fly   255 TFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVS-SLTIHIRRHTGD 318
            .|..:.||..| |..|               |.||:.|   |..||.:|.:. ::..|::.|||:
Human   390 FFSHRSTLNMH-QRVH---------------AGKRLYK---CSECGKAFSLKHNVVQHLKIHTGE 435

  Fly   319 NPYKCDQCEKAFPRSQDLSLHMRQHTG-----------------ERPSECKICSKKFISQNKLAR 366
            .||:|.:|||||.|...|..|.:.||.                 .||..|..|.|.|::|..|..
Human   436 RPYECTECEKAFVRKSHLVQHQKIHTDAFSKRSDLIQHKRIDIRPRPYTCSECGKAFLTQAHLVG 500

  Fly   367 HMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTG-----------------ERPYQCGVCGESF 414
            |.::|||:|||.|..|:|:||:.:.|..|.:.||.                 .|||.|..||::|
Human   501 HQKIHTGERPYECTQCAKAFVRKSHLVQHEKIHTDAFSKRSDLIQHKRIDLRPRPYVCSECGKAF 565

  Fly   415 VCGSHLNIHRNRKGHLIAVIPGNEVEAN----FAADPYVNARVNQRRSEDIERMRLQRIPENQLQ 475
            :..:||:      ||..........|.|    |..|.|                      :..:.
Human   566 LTQAHLD------GHQKIQTGERRYECNECGKFFLDSY----------------------KLVIH 602

  Fly   476 QRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSHYEIERVYE 523
            ||:....||      |||..|.:.|:....|:.|:..   :..||.||
Human   603 QRIHTGEKP------YKCSKCGKFFRYRCTLSRHQKV---HTGERPYE 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	17/95 (18%)
		C2H2 Zn finger	205..226	CDD:275368	7/31 (23%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	41/114 (36%)
		C2H2 Zn finger	296..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	307..330	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..358	CDD:290200	9/39 (23%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	11/41 (27%)
		C2H2 Zn finger	407..424	CDD:275368	6/16 (38%)
ZNF749	NP_001018855.2	KRAB	8..62	CDD:214630
		KRAB	10..47	CDD:279668
		C2H2 Zn finger	202..218	CDD:275368	0/15 (0%)
		C2H2 Zn finger	226..246	CDD:275368	2/19 (11%)
		C2H2 Zn finger	258..274	CDD:275368	0/15 (0%)
		COG5048	295..689	CDD:227381	103/403 (26%)
		C2H2 Zn finger	300..320	CDD:275368	1/19 (5%)
		C2H2 Zn finger	328..348	CDD:275368	6/19 (32%)
		C2H2 Zn finger	356..376	CDD:275368	4/19 (21%)
		zf-H2C2_2	371..393	CDD:290200	4/21 (19%)
		C2H2 Zn finger	384..404	CDD:275368	7/20 (35%)
		C2H2 Zn finger	412..432	CDD:275368	5/19 (26%)
		zf-H2C2_2	424..449	CDD:290200	12/24 (50%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		C2H2 Zn finger	558..578	CDD:275368	8/25 (32%)
		C2H2 Zn finger	586..606	CDD:275368	6/41 (15%)
		zf-H2C2_2	599..623	CDD:290200	9/29 (31%)
		C2H2 Zn finger	614..634	CDD:275368	5/22 (23%)
		zf-H2C2_2	627..649	CDD:290200	6/18 (33%)
		C2H2 Zn finger	642..662	CDD:275368	147/633 (23%)
		C2H2 Zn finger	670..689	CDD:275368
		C2H2 Zn finger	698..718	CDD:275368
		C2H2 Zn finger	727..745	CDD:275368
		C2H2 Zn finger	753..773	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930