DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZBTB41

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_919290.2	Gene:	ZBTB41 / 360023	HGNCID:	24819	Length:	909	Species:	Homo sapiens

Alignment Length:	607	Identity:	130/607 - (21%)
Similarity:	219/607 - (36%)	Gaps:	173/607 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HLCQNCARR------------------LIGAYEFIVEVE---NAHETLQNLFEQQEVAAKPDEVH 106
            |.|:.|:|.                  |:|....:..:|   :|..:.:|    ::...|.|:..
Human   207 HQCKFCSRHFCYKKSLENHLAKTHRSLLLGKKHGLKMLERSFSARRSKRN----RKCPVKFDDTS 267

  Fly   107 VDVVELIDQDDVVSMAQY------------LSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLYA 159
            .|..|..|..|.::...:            ..:.:..:..|:||:..|:     .||:.|:....
Human   268 DDEQESGDGSDNLNQENFDKEKSDRNDSEDPGSEYNAEEDELEEEMSDE-----YSDIEEQSEKD 327

  Fly   160 SEDRDDEPEDSFQL---------------------------------------------KPRPDE 179
            ..|.::|||....:                                             ||...:
Human   328 HNDAEEEPEAGDSVGNVHEGLTPVVIQNSNKKILQCPKCDKTFDRIGKYESHTRVHTGEKPFECD 392

  Fly   180 IENRELSRPSQLG-SRLNHSANFIY-----KCAVCPRVFAKSESLTRHFSQAHKLTAD--VAAMK 236
            |.::..|..|.|. .|..||....:     ||..|.::.|..::|.:|..:.|...|.  ::..|
Human   393 ICHQRYSTKSNLTVHRKKHSNETEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPENAQEFISIKK 457

  Fly   237 LANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETT--DNSARKRIAKRR----- 294
            ..:||     ..|:.|.::|.|:..|..||.....|    :|.:.|  :...:.|.|:.:
Human   458 TKSES-----WKCDICKKSFTRRPHLEEHMILHSQD----KPFKCTYCEEHFKSRFARLKHQEKF 513

  Fly   295 -----DCPHCGLSF-PVSSLTIHIR-RHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECK 352
                 .|..||..| ...:|..||. .|.|...:.|..|.|:......|..|:|.|:||:|..|.
Human   514 HLGPFPCDICGRQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCS 578

  Fly   353 ICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCG 417
            ||.:.|...:....|:|:|...:.|.|..|.|:|::.:.|..|.:.|:||:.:||..||:.|...
Human   579 ICGQSFRHGSSYRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRR 643

  Fly   418 SHLNIHRNRKGHLIAVIPGNEVEANFAADPY---VNARVNQRRSEDIERMRLQRIPENQLQQRLE 479
            .||.:| .:..||     |.:|...:.|..:   |..::.:.:|            ..::..|..
Human   644 DHLTVH-YKSVHL-----GEKVWQKYKATFHQCDVCKKIFKGKS------------SLEMHFRTH 690

  Fly   480 NLPKPDVPAMCYKCGVCEQKFKSGALLTVH--------------------RNKMSHYEIERVYE- 523
            :..||      |||.:|.|.|:....||.|                    |.....|.|:.|:|
Human   691 SGEKP------YKCQICNQSFRIKKTLTKHLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHEI 749

  Fly   524 ----NPFG-KNQKIIK--AEYN 538
                :|.. ..:|::.  .||:
Human   750 KSPDDPLSTSEEKLVSLPVEYS 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	8/49 (16%)
		C2H2 Zn finger	205..226	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	31/108 (29%)
		C2H2 Zn finger	296..315	CDD:275368	7/20 (35%)
		zf-H2C2_2	307..330	CDD:290200	8/23 (35%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..358	CDD:290200	10/22 (45%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..388	CDD:290200	8/23 (35%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	391..416	CDD:290200	10/24 (42%)
		C2H2 Zn finger	407..424	CDD:275368	6/16 (38%)
ZBTB41	NP_919290.2	BTB_POZ_ZBTB41	66..179	CDD:349535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344		18/100 (18%)
		C2H2 Zn finger	363..383	CDD:275368	0/19 (0%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		C2H2 Zn finger	424..442	CDD:275368	5/17 (29%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..510	CDD:275368	3/16 (19%)
		C2H2 Zn finger	520..541	CDD:275368	7/20 (35%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)
		zf-C2H2	603..625	CDD:395048	7/21 (33%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	633..651	CDD:275368	7/18 (39%)
		C2H2 Zn finger	670..687	CDD:275368	2/28 (7%)
		C2H2 Zn finger	698..718	CDD:275368	7/19 (37%)
		C2H2 Zn finger	726..743	CDD:275368	2/16 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000