back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF404

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001028891.2	Gene:	ZNF404 / 342908	HGNCID:	19417	Length:	552	Species:	Homo sapiens

Alignment Length:	349	Identity:	99/349 - (28%)
Similarity:	152/349 - (43%)	Gaps:	76/349 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 NHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVA--------------AMKLANESCGTGL 246
            :|:....|:|..|.:.|.    :.:||.:..|:..|:.              :..:.::...||:
Human   152 DHTGVIPYECNECGKAFV----VFQHFIRHRKIHTDLKPYECNGCEKAFRFYSQLIQHQIIHTGM 212

  Fly   247 --LTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRI-------------AKRRDC 296
              ..|:.|.:.|:|...|..| |..|   :.|:|.|..:.....|:             .|...|
Human   213 KPYECKQCGKAFRRHSHLTEH-QKIH---VGLKPFECKECGETFRLYRHMCLHQKIHHGVKPYKC 273

  Fly   297 PHCGLSF-PVSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFIS 360
            ..||.:| ..|||..|.:.|:|:.||||:||||||.||..|..|.|.||||:|.||..|.|.|..
Human   274 KECGKAFGHRSSLYQHKKIHSGEKPYKCEQCEKAFVRSYLLVEHQRSHTGEKPHECMECGKAFGK 338

  Fly   361 QNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGS----HLN 421
            .:.|.:|.|:|:.::.|.||.|.|:|.:.:.|..|.|.||||:|::|..||::|...|    |..
Human   339 GSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKTFKLHSYLIQHQI 403

  Fly   422 IHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDV 486
            ||.:.|                   ||...:..:..|         |:.:.:..|.:....||
Human   404 IHTDLK-------------------PYECKQCGKAFS---------RVGDLKTHQSIHAGEKP-- 438

  Fly   487 PAMCYKCGVCEQKFKSGALLTVHR 510
                |:|..|.:.|:..:.|..|:
Human   439 ----YECKECGKTFRLNSQLIYHQ 458

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.