DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and Gzf1

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001101258.1	Gene:	Gzf1 / 311508	RGDID:	1562321	Length:	707	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	136/524 - (25%)
Similarity:	194/524 - (37%)	Gaps:	136/524 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQ---EVAAKPDEVHVDVVELIDQDDVVSMA 122
            |....:..:.||.|...| ||:.....| :.|.|||   |.|||.|:...|
  Rat   216 PFPKIRRASGRLAGKKVF-VEIPKKKYT-RRLREQQKSAEEAAKNDKCPQD-------------- 264

  Fly   123 QYLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELSR 187
                .|...:.||.|.....:.|.|  |...||.|...|...:|.|..       |..|.::
  Rat   265 ----QSPDNERVEAEPASKSEACPA--SVEREESLQKVEGEKEEEEGK-------DGEEKKK--- 313

  Fly   188 PSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGL------ 246
                       :||  :|.||.:.|...:|..:|....|.:..:|.   ...::||...
  Rat   314 -----------SNF--QCTVCDKAFLYEKSFLKHIKYHHGVATEVV---YRCDTCGQTFANRCNL 362

  Fly   247 -------------LTCEHCPRTFKRQDTLRRHMQAFH----------------PDAIALEPEETT 282
                         ..||.|.:.|||:..::||:...|                ....||...|.|
  Rat   363 KSHQRHVHSSERHFPCEMCAKKFKRKKDVKRHVLQVHEGGGERHRCGQCGKGLSSKTALRLHERT 427

  Fly   283 DNSARKRIAKRRD-----------------------CPHCGLSFPVSSLTI-HIRRHTGDNPYKC 323
            ....:.....:.|                       |..||..|..:.:.| |.|.|||:.|:.|
  Rat   428 HTGDKPYGCTKCDAKFSQPSALKTHLRVHTGERPFVCDECGARFTQNHMLIYHKRCHTGERPFMC 492

  Fly   324 DQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQ 388
            :.|.|:|...:.|..|.|.|||.:|.:|::|.:.|..:|.|.:|:::|||:|||.|..|.|.|.|
  Rat   493 ETCGKSFASKEYLKHHNRIHTGSKPFKCEVCLRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQ 557

  Fly   389 SNDLKIHMRRHTGERPYQCGVCGESFVCGS----HLNIHRNR---KGHLIAV--IPGNEVEANFA 444
            .|.|:.|.|.||||:||.|..||.:|...|    |.:||...   |..|:.|  .|.|: |....
  Rat   558 VNALQRHHRIHTGEKPYMCNACGRTFTDKSTLRRHTSIHDKNTPWKSFLVIVDGSPKND-EGQKT 621

  Fly   445 ADP---YVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCG---VCEQKFKSG 503
            ..|   |.:.:::.|.....|......:.|.|          .:|||:.....   .|:......
  Rat   622 EQPDEEYASPKLSDRLLSFGENSHFNNLLEVQ----------GNVPAVQENSSTDTACKAVVSQD 676

  Fly   504 ALLT 507
            ||||
  Rat   677 ALLT 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	8/30 (27%)
		C2H2 Zn finger	205..226	CDD:275368	6/20 (30%)
		C2H2 Zn finger	249..266	CDD:275368	7/16 (44%)
		COG5048	<294..>391	CDD:227381	40/120 (33%)
		C2H2 Zn finger	296..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	307..330	CDD:290200	10/23 (43%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	9/22 (41%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	7/20 (35%)
Gzf1	NP_001101258.1	BTB	21..125	CDD:279045
		BTB	32..125	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..221		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..309		24/92 (26%)
		C2H2 Zn finger	318..338	CDD:275370	6/19 (32%)
		C2H2 Zn finger	349..370	CDD:275368	2/20 (10%)
		C2H2 Zn finger	408..428	CDD:275368	3/19 (16%)
		COG5048	<411..539	CDD:227381	33/127 (26%)
		C2H2 Zn finger	436..456	CDD:275368	1/19 (5%)
		zf-H2C2_2	448..473	CDD:290200	4/24 (17%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	476..501	CDD:290200	11/24 (46%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		zf-H2C2_2	504..529	CDD:290200	10/24 (42%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		zf-H2C2_2	532..557	CDD:290200	12/24 (50%)
		COG5048	544..>601	CDD:227381	26/56 (46%)
		C2H2 Zn finger	548..568	CDD:275368	9/19 (47%)
		zf-H2C2_2	560..584	CDD:290200	12/23 (52%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000