Protein Alignment CG3281 and ZNF875

DIOPT Version :10

• Sequence 1: NP_650132.1
• Gene: CG3281 / 41445
• FlyBaseID: FBgn0260741
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_016882161.1
• Gene: ZNF875 / 284459
• HGNCID: 4928
• Length: 704
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 138/569 - (24%)
• Similarity: 209/569 - (36%)
• Gaps: 158/569 - (27%)

  Fly     4 PEIHVNISSQTCRVCLETHETNLYVHDEIKYNDLKLELW--QLLEAVSKLKWTWTDPNLPMHLCQ 66
            |||.:   |.:|.:...:.:.            |...:|  .|.:..|.| |.....:|..|..:
Human   153 PEIQL---SPSCPLIFSSQQA------------LSQHVWLSHLSQLFSSL-WAGNPLHLGKHYPE 201

  Fly    67 NCARR-----LIGAYEFIVEVENAHETLQNLF-----------------EQQEVAAKPDEVHVDV 109
            :..::     ..|..|:|.|.|::    :.||                 |||...:|.|...||:
Human   202 DQKQQQDPFCFSGKAEWIQEGEDS----RLLFGRVSKNGTSKALSSPPEEQQPAQSKEDNTVVDI 262

  Fly   110 -------VELIDQDDVVSMAQYLSTSFAEQHVEMEEKYG------DQDCSAFTSDVGEEPLYASE 161
                   .:|.:.|.|:...:.  :.|.|  ::.|| :|      ....|...:..||.|...:|
Human   263 GSSPERRADLEETDKVLHGLEV--SGFGE--IKYEE-FGPGFIKESNLLSLQKTQTGETPYMYTE 322

  Fly   162 DRDDEPEDSFQLK-PRPDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQA 225
            ..|.....|..:| ||                   .||....|.|..|.|.|....:|..| .:.
Human   323 WGDSFGSMSVLIKNPR-------------------THSGGKPYVCRECGRGFTWKSNLITH-QRT 367

  Fly   226 HKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRI 290
            |.               |.....|:.|.|.|..:..|..| |..|.   .|:|..
Human   368 HS---------------GEKPYVCKDCGRGFTWKSNLFTH-QRTHS---GLKPYV---------- 403

  Fly   291 AKRRDCPHCGLSFPV-SSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKIC 354
                 |..||.||.: |:|..|.|.|||:.||.|.:|.:.|.:...|..|.|.|:||:|..|:.|
Human   404 -----CKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEKPYICREC 463

  Fly   355 SKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSH 419
            .:.|..::.|.||:|.|||::||.|..|.:.|...::||.|.|.|:|.:||.|..||:.|...|:
Human   464 EQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQCFSLKSN 528

  Fly   420 LNIHR------------------NRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRL 466
            ||.|:                  .||..|     ......:....|:|.|...:..::....:..
Human   529 LNKHQRSHTGEKPFVCTECGRGFTRKSTL-----STHQRTHSGEKPFVCAECGRGFNDKSTLISH 588

  Fly   467 QRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSH 515
            ||....            :.|.||.:||   ::|:...  .:.|:|.:|
Human   589 QRTHSG------------EKPFMCRECG---RRFRQKP--NLFRHKRAH 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	15..91	CDD:214871	14/82 (17%)
		C2H2 Zn finger	205..226	CDD:275368	6/20 (30%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	39/97 (40%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:463886	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:463886	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	7/16 (44%)
ZNF875	XP_016882161.1	KRAB	77..136	CDD:214630
		C2H2 Zn finger	324..340	CDD:275368	5/34 (15%)
		COG5048	344..703	CDD:227381	91/334 (27%)
		C2H2 Zn finger	348..368	CDD:275368	6/20 (30%)
		C2H2 Zn finger	376..396	CDD:275368	7/20 (35%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368	8/19 (42%)
		C2H2 Zn finger	544..564	CDD:275368	3/24 (13%)
		C2H2 Zn finger	572..592	CDD:275368	3/19 (16%)
		C2H2 Zn finger	600..620	CDD:275368	6/24 (25%)
		C2H2 Zn finger	626..646	CDD:275368
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368