DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF875

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_016882161.1	Gene:	ZNF875 / 284459	HGNCID:	4928	Length:	704	Species:	Homo sapiens

Alignment Length:	576	Identity:	140/576 - (24%)
Similarity:	209/576 - (36%)	Gaps:	172/576 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PEIHVNISSQTCRVCLETHETNLYVHDEIKYNDLKLELW--QLLEAVSKLKWTWTDPNLPMHLCQ 66
            |||.:   |.:|.:...:.:.            |...:|  .|.:..|.| |...    |:||.:
Human   153 PEIQL---SPSCPLIFSSQQA------------LSQHVWLSHLSQLFSSL-WAGN----PLHLGK 197

  Fly    67 N------------CARRLIGAYEFIVEVENAHETLQNLF-----------------EQQEVAAKP 102
            :            |   ..|..|:|.|.|::    :.||                 |||...:|.
Human   198 HYPEDQKQQQDPFC---FSGKAEWIQEGEDS----RLLFGRVSKNGTSKALSSPPEEQQPAQSKE 255

  Fly   103 DEVHVDV-------VELIDQDDVVSMAQYLSTSFAEQHVEMEEKYG------DQDCSAFTSDVGE 154
            |...||:       .:|.:.|.|:...:.  :.|.|  ::.|| :|      ....|...:..||
Human   256 DNTVVDIGSSPERRADLEETDKVLHGLEV--SGFGE--IKYEE-FGPGFIKESNLLSLQKTQTGE 315

  Fly   155 EPLYASEDRDDEPEDSFQLK-PRPDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESL 218
            .|...:|..|.....|..:| ||                   .||....|.|..|.|.|....:|
Human   316 TPYMYTEWGDSFGSMSVLIKNPR-------------------THSGGKPYVCRECGRGFTWKSNL 361

  Fly   219 TRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTD 283
            ..| .:.|.               |.....|:.|.|.|..:..|..| |..|.   .|:|..
Human   362 ITH-QRTHS---------------GEKPYVCKDCGRGFTWKSNLFTH-QRTHS---GLKPYV--- 403

  Fly   284 NSARKRIAKRRDCPHCGLSFPV-SSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGER 347
                        |..||.||.: |:|..|.|.|||:.||.|.:|.:.|.:...|..|.|.|:||:
Human   404 ------------CKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEK 456

  Fly   348 PSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGE 412
            |..|:.|.:.|..::.|.||:|.|||::||.|..|.:.|...::||.|.|.|:|.:||.|..||:
Human   457 PYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQ 521

  Fly   413 SFVCGSHLNIHR------------------NRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSE 459
            .|...|:||.|:                  .||..|     ......:....|:|.|...:..::
Human   522 CFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTL-----STHQRTHSGEKPFVCAECGRGFND 581

  Fly   460 DIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSH 515
            ....:..||....            :.|.||.:||   ::|:...  .:.|:|.:|
Human   582 KSTLISHQRTHSG------------EKPFMCRECG---RRFRQKP--NLFRHKRAH 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	16/91 (18%)
		C2H2 Zn finger	205..226	CDD:275368	6/20 (30%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	39/97 (40%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..358	CDD:290200	9/22 (41%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	7/16 (44%)
ZNF875	XP_016882161.1	KRAB	77..136	CDD:214630
		C2H2 Zn finger	324..340	CDD:275368	5/34 (15%)
		COG5048	344..703	CDD:227381	91/334 (27%)
		C2H2 Zn finger	348..368	CDD:275368	6/20 (30%)
		C2H2 Zn finger	376..396	CDD:275368	7/20 (35%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368	8/19 (42%)
		C2H2 Zn finger	544..564	CDD:275368	3/24 (13%)
		C2H2 Zn finger	572..592	CDD:275368	3/19 (16%)
		C2H2 Zn finger	600..620	CDD:275368	6/24 (25%)
		C2H2 Zn finger	626..646	CDD:275368
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930