DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and Zfp37

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001277279.1	Gene:	Zfp37 / 22696	MGIID:	99181	Length:	594	Species:	Mus musculus

Alignment Length:	553	Identity:	138/553 - (24%)
Similarity:	212/553 - (38%)	Gaps:	150/553 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 WQLLEAVSKLKWTWTDPNLPMHLCQNCAR-RLIGAYEFIVEVENAHETLQNLFEQQEVA------ 99
            |:.||.|.  :..:.|..|     :||:. ..:|.       ::..:.:.::.|::|.:
Mouse    17 WEQLEPVQ--RDVYKDTKL-----ENCSNPASMGN-------QDPKQDIVSVLEEEEPSSGKGKK 67

  Fly   100 AKPDEVH-------VDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVG---- 153
            |.|..:.       ......:.|||.....:..|.|...:.|.:.:|..:   |..:|:.|
Mouse    68 ASPSSLKKIARPKTAGTSAKLQQDDEHREEKQKSQSKLTKEVTLRKKSSN---SKKSSEYGLLEN 129

  Fly   154 ----------EEPLYASEDR-DDEPEDSFQLKPRPDEIENRELSRPSQLGSRLNHSANFI----- 202
                      |:.|..|..| .:..::|..||.:||...:...|        |:|||:.:
Mouse   130 KSLHSKHTPSEKKLLKSSSRGKNSNQNSDSLKKKPDTANDHRKS--------LSHSASDVNKDEI 186

  Fly   203 ---YKCAVCP-----------RVFAKSESLTRHFSQAHKLTADVAAMKLANESC----------G 243
               .||...|           :...|.|.:.|| |.:|.....:...:.....|          |
Mouse   187 PTRKKCDKLPNNKLSDKGDKNQTSKKCEKVCRH-SASHTKEDKIQTGEKRKSHCRTPSKPEKAPG 250

  Fly   244 TGL-LTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVSS 307
            :|. ..|.||.:....:..|..|.:....:                   |..:|..||::|...|
Mouse   251 SGKPYECNHCGKVLSHKQGLLDHQRTHTGE-------------------KPYECNECGIAFSQKS 296

  Fly   308 -LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLH 371
             |.:|.|.|||:.||:|:||.||......|:.|:|.||||:|.:|..|.|.|...:.|.:|:|.|
Mouse   297 HLVVHQRTHTGEKPYECEQCGKAHGHKHALTDHLRIHTGEKPYKCNECGKTFRHSSNLMQHLRSH 361

  Fly   372 TGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGS----HLNIHRNRKGHLIA 432
            ||::||.||.|.|||..::.|..|:|.||||.||:|..||::|..||    |:.||...|
Mouse   362 TGEKPYECKECGKSFRYNSSLTEHVRTHTGEIPYECNECGKAFKYGSSLTKHMRIHTGEK----- 421

  Fly   433 VIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCE 497
            ....||....|:...::                       .:.||.....||      |||..|.
Mouse   422 PFECNECGKTFSKKSHL-----------------------VIHQRTHTKEKP------YKCDECG 457

  Fly   498 QKFKSGALLTVHRNKMSHYEIERVYENPFGKNQ 530
            :.|...:.||.|..  :|     ..:.||..||
Mouse   458 KAFGHSSSLTYHMR--TH-----TGDCPFECNQ 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	9/50 (18%)
		C2H2 Zn finger	205..226	CDD:275368	7/31 (23%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	44/97 (45%)
		C2H2 Zn finger	296..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..330	CDD:290200	13/23 (57%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	11/22 (50%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	14/23 (61%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	8/20 (40%)
Zfp37	NP_001277279.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..253		48/261 (18%)
		KRAB	15..62	CDD:214630	11/58 (19%)
		KRAB_A-box	<15..42	CDD:143639	8/31 (26%)
		COG5048	124..486	CDD:227381	116/429 (27%)
		C2H2 Zn finger	257..277	CDD:275368	5/19 (26%)
		zf-H2C2_2	270..294	CDD:290200	7/42 (17%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		zf-H2C2_2	297..319	CDD:290200	11/21 (52%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		zf-H2C2_2	325..350	CDD:290200	12/24 (50%)
		C2H2 Zn finger	341..361	CDD:275368	7/19 (37%)
		zf-H2C2_2	353..378	CDD:290200	14/24 (58%)
		C2H2 Zn finger	369..389	CDD:275368	9/19 (47%)
		zf-H2C2_2	381..406	CDD:290200	13/24 (54%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..433	CDD:290200	6/28 (21%)
		C2H2 Zn finger	425..445	CDD:275368	5/42 (12%)
		zf-H2C2_2	437..460	CDD:290200	8/51 (16%)
		zf-C2H2	451..473	CDD:278523	8/23 (35%)
		C2H2 Zn finger	453..473	CDD:275368	6/21 (29%)
		zf-H2C2_2	465..490	CDD:290200	8/26 (31%)
		C2H2 Zn finger	481..501	CDD:275368	2/3 (67%)
		zf-H2C2_2	494..518	CDD:290200
		C2H2 Zn finger	509..529	CDD:275368
		zf-H2C2_2	521..545	CDD:290200
		C2H2 Zn finger	537..557	CDD:275368
		zf-H2C2_2	550..574	CDD:290200
		C2H2 Zn finger	565..585	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930