DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and Zbtb41

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_766231.2	Gene:	Zbtb41 / 226470	MGIID:	2444487	Length:	908	Species:	Mus musculus

Alignment Length:	681	Identity:	146/681 - (21%)
Similarity:	246/681 - (36%)	Gaps:	208/681 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LETHETNLY------VHDEIKYNDLKLELWQLL--EAVSKLKWTWTDPNLP-------------M 62
            |.|.|..:|      |.:..|:.|: ::..:||  |.|:..:...|:.:.|             .
Mouse   144 LYTSEFFVYKYEIPLVLEAAKFLDI-IDAVKLLNNENVAAFQAELTEKSSPEETLNELTGRLSSS 207

  Fly    63 HLCQNCARR------------------LIGAYEFIVEVENAHETLQN--------LFE-----QQ 96
            |.|:.|:|.                  |:|....:..:|.:..|.::        .||     :|
Mouse   208 HQCKFCSRHFCYKKSLENHLAKTHRSLLLGKKHGLKMLERSFSTRRSKRNRKCPVKFEDTSDDEQ 272

  Fly    97 EVAAKPDEVHVD--VVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLYA 159
            |.....|.:|.:  ..|..|::|    ::...:.:..:..|:||:..|:|.....||       .
Mouse   273 ESGDGSDNLHQESSEKERSDRND----SEDPGSEYNAEDEELEEEVSDEDSDTEQSD-------K 326

  Fly   160 SEDRDDEPE--DS-----------------------------FQL--------------KPRPDE 179
            ..|.::|||  ||                             |..              ||...:
Mouse   327 DNDAEEEPEAGDSAGSIHEGLAPVIIQNSNKKILQCPKCDKTFDRIGKYESHTRVHTGEKPFECD 391

  Fly   180 IENRELSRPSQLGSRLNHSANFI------YKCAVCPRVFAKSESLTRHFSQAHKLTAD--VAAMK 236
            |.::..|..|.|.......:|.:      :||..|.::.|..::|.:|..:.|...|.  ::..|
Mouse   392 ICHQRYSTKSNLTVHRKKHSNEVEFHRKEHKCPYCNKLHASKKTLAKHVKRFHPENAQEFISIKK 456

  Fly   237 LANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETT--DNSARKRIAKRR----- 294
            ..:||     ..|:.|.::|.|:..|..||.....|    :|.:.|  :...:.|.|:.:
Mouse   457 TKSES-----WKCDICKKSFTRRPHLEEHMILHSQD----KPFKCTYCEEHFKSRFARLKHQEKF 512

  Fly   295 -----DCPHCGLSF-PVSSLTIHIR-RHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECK 352
                 .|..||..| ...:|..||. .|.|...:.|..|.|:......|..|:|.|:||:|..|.
Mouse   513 HLGPFPCDICGRQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCS 577

  Fly   353 ICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCG 417
            ||.:.|...:....|:|:|...:.|.|..|.|:|::.:.|..|.:.|:||:.:||..||:.|...
Mouse   578 ICGQSFRHGSSYRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRR 642

  Fly   418 SHLNIHRNRKGHLIAVIPGNEVEANFAADPY---VNARVNQRRSEDIERMRLQRIPENQLQQRLE 479
            .||.:| .:..||     |.:|...:.|..:   |..::.:.:|            ..::..|..
Mouse   643 DHLTVH-YKSVHL-----GEKVWQKYKATFHQCDVCKKIFKGKS------------SLEMHFRTH 689

  Fly   480 NLPKPDVPAMCYKCGVCEQKFKSGALLTVH--------------------RNKMSHYEIERVY-- 522
            :..||      |||.:|.|.|:....||.|                    |.....|.|:.|:
Mouse   690 SGEKP------YKCQICNQSFRIKKTLTKHLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHGI 748

  Fly   523 ENP-----------------FGKNQKIIKAE 536
            ::|                 :..:.||.:||
Mouse   749 KSPDDSLSTSEEKLMSLPMEYSSDDKIFQAE 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	21/119 (18%)
		C2H2 Zn finger	205..226	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	31/108 (29%)
		C2H2 Zn finger	296..315	CDD:275368	7/20 (35%)
		zf-H2C2_2	307..330	CDD:290200	8/23 (35%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..358	CDD:290200	10/22 (45%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-H2C2_2	364..388	CDD:290200	8/23 (35%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	391..416	CDD:290200	10/24 (42%)
		C2H2 Zn finger	407..424	CDD:275368	6/16 (38%)
Zbtb41	NP_766231.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..59
		BTB_POZ_ZBTB41	67..180	CDD:349535	10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344		22/102 (22%)
		CobT	<270..>339	CDD:130712	18/79 (23%)
		C2H2 Zn finger	362..382	CDD:275368	1/19 (5%)
		C2H2 Zn finger	390..410	CDD:275368	4/19 (21%)
		C2H2 Zn finger	423..441	CDD:275368	5/17 (29%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..509	CDD:275368	3/16 (19%)
		C2H2 Zn finger	519..540	CDD:275368	7/20 (35%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		zf-H2C2_2	561..585	CDD:372612	11/23 (48%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		zf-C2H2	602..624	CDD:333835	7/21 (33%)
		C2H2 Zn finger	604..624	CDD:275368	6/19 (32%)
		zf-H2C2_2	616..641	CDD:372612	10/24 (42%)
		C2H2 Zn finger	632..650	CDD:275368	7/18 (39%)
		C2H2 Zn finger	669..686	CDD:275368	2/28 (7%)
		C2H2 Zn finger	697..717	CDD:275368	7/19 (37%)
		C2H2 Zn finger	725..742	CDD:275368	2/16 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000