Protein Alignment CG3281 and ZNF25

DIOPT Version :10

• Sequence 1: NP_650132.1
• Gene: CG3281 / 41445
• FlyBaseID: FBgn0260741
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001316576.1
• Gene: ZNF25 / 219749
• HGNCID: 13043
• Length: 460
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 132/496 - (26%)
• Similarity: 199/496 - (40%)
• Gaps: 102/496 - (20%)

  Fly    34 YNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNCARRLIGAYEFIVEVENAHETL-QNLFEQQE 97
            |.|:.||.:..|.:|.   :....||....|.|       |...:|:|||..|... ::|:...:
Human    37 YKDVMLENYSHLVSVG---YHVNKPNAVFKLKQ-------GKEPWILEVEFPHRGFPEDLWSIHD 91

  Fly    98 VAAKPDEVHVDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLYASED 162
            :.|:..|...      .......:.::..|...|:..|.:| .|...|......|.:......:.
Human    92 LEARYQESQA------GNSRNGELTKHQKTHTTEKACECKE-CGKFFCQKSALIVHQHTHSKGKS 149

  Fly   163 RD-DEPEDSFQLKPRPDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAH 226
            .| |:...||.        :|.:|.|..::     |:.:..|:|..|.::|....||:||. :.|
Human   150 YDCDKCGKSFS--------KNEDLIRHQKI-----HTRDKTYECKECKKIFYHLSSLSRHL-RTH 200

  Fly   227 KLTADVAAMKLANESCGTGLLTCEHCPRTFKRQDTLRRHMQA---------------FHPDAIAL 276
                           .|.....|..|.::|.::..|..|.:.               |:..|..:
Human   201 ---------------AGEKPYECNQCEKSFYQKPHLTEHQKTHTGEKPFECTECGKFFYVKAYLM 250

  Fly   277 EPEETTDNSARKRIAKRRDCPHCGLSFPVSS-LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHM 340
            ..::|....      |..:|..||.:|...| ||:|.|.|||:.||||.:|.|.|.|:..|..|.
Human   251 VHQKTHTGE------KPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKECGKFFSRNSHLKTHQ 309

  Fly   341 RQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPY 405
            |.||||:|.|||.|.|.|..::.|..|.|.|||::|:.|..|.|:|...:||..|.|:||||:||
Human   310 RSHTGEKPYECKECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPY 374

  Fly   406 QCGVCGESFVCGSHLNIH-RNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRI 469
            :|..||:||...|.|.:| |...|.                .||......:..|:....:
Human   375 ECTECGKSFAVNSVLRLHQRTHTGE----------------KPYACKECGKSFSQKSHFI----- 418

  Fly   470 PENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHR 510
                :.||.....||      |:|..|.:.|...:.||.|:
Human   419 ----IHQRKHTGEKP------YECQECGETFIQKSQLTAHQ 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	15..91	CDD:214871	16/57 (28%)
		C2H2 Zn finger	205..226	CDD:275368	7/20 (35%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	45/97 (46%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:463886	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:463886	15/24 (63%)
		C2H2 Zn finger	407..424	CDD:275368	8/17 (47%)
ZNF25	NP_001316576.1	KRAB	12..72	CDD:214630	11/44 (25%)
		C2H2 Zn finger	124..144	CDD:275368	4/20 (20%)
		COG5048	148..457	CDD:227381	106/368 (29%)
		C2H2 Zn finger	152..172	CDD:275368	6/32 (19%)
		C2H2 Zn finger	180..200	CDD:275368	7/20 (35%)
		C2H2 Zn finger	208..228	CDD:275368	5/19 (26%)
		C2H2 Zn finger	236..256	CDD:275368	2/19 (11%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		C2H2 Zn finger	404..424	CDD:275368	3/28 (11%)
		C2H2 Zn finger	432..452	CDD:275368	6/18 (33%)