DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF169

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_003439.2	Gene:	ZNF169 / 169841	HGNCID:	12957	Length:	604	Species:	Homo sapiens

Alignment Length:	356	Identity:	98/356 - (27%)
Similarity:	135/356 - (37%)	Gaps:	99/356 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 RELSRPSQLG-SRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGL 246
            |..|:.:.|. .:..||....|.|..|.|.|..:.|||.| .:.|.               |...
Human   270 RRFSQKASLSIHQRKHSGEKPYVCRECGRHFRYTSSLTNH-KRIHS---------------GERP 318

  Fly   247 LTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSF-PVSSLTI 310
            ..|:.|.|.|:::..|..| |..|     ||.:...             ||.||..| ..:||..
Human   319 FVCQECGRGFRQKIALLLH-QRTH-----LEEKPFV-------------CPECGRGFCQKASLLQ 364

  Fly   311 HIRRHTGDNPYKCDQCEKAFPRSQDLSL-HMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQ 374
            |...|||:.|:.|.:|.::| |.|.|.| |...|:||:|..|..|...|..:..|.||.|.|||:
Human   365 HQSSHTGERPFLCLECGRSF-RQQSLLLSHQVTHSGEKPYVCAECGHSFRQKVTLIRHQRTHTGE 428

  Fly   375 RPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEV 439
            :||.|..|.:.|.|...|..|.|.||||:||.|..||..|  |..:.:.|:::.|
Human   429 KPYLCPQCGRGFSQKVTLIGHQRTHTGEKPYLCPDCGRGF--GQKVTLIRHQRTH---------- 481

  Fly   440 EANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGA 504
                                                       ..:.|.:|.|||   :.|...:
Human   482 -------------------------------------------TGEKPYLCPKCG---RAFGFKS 500

  Fly   505 LLTVHRNKMSHYE--IERVYENPFGKNQKII 533
            |||.|:...|..|  ::||.....|:...:|
Human   501 LLTRHQRTHSEEELYVDRVCGQGLGQKSHLI 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	8/20 (40%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	40/98 (41%)
		C2H2 Zn finger	296..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..330	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	8/20 (40%)
		zf-H2C2_2	335..358	CDD:290200	9/23 (39%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	5/16 (31%)
ZNF169	NP_003439.2	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..182
		COG5048	223..>584	CDD:227381	98/356 (28%)
		zf-C2H2	235..257	CDD:278523
		C2H2 Zn finger	237..257	CDD:275368
		zf-H2C2_2	249..274	CDD:290200	1/3 (33%)
		C2H2 Zn finger	265..285	CDD:275368	3/14 (21%)
		zf-H2C2_2	277..302	CDD:290200	8/24 (33%)
		C2H2 Zn finger	293..313	CDD:275368	8/20 (40%)
		zf-H2C2_2	305..330	CDD:290200	10/40 (25%)
		C2H2 Zn finger	321..341	CDD:275368	7/20 (35%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	377..397	CDD:275368	8/20 (40%)
		zf-C2H2	403..425	CDD:278523	7/21 (33%)
		C2H2 Zn finger	405..425	CDD:275368	7/19 (37%)
		zf-H2C2_2	418..442	CDD:290200	12/23 (52%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		zf-H2C2_2	449..468	CDD:290200	11/18 (61%)
		C2H2 Zn finger	461..481	CDD:275368	6/21 (29%)
		zf-H2C2_2	474..496	CDD:290200	7/77 (9%)
		C2H2 Zn finger	489..509	CDD:275368	9/22 (41%)
		C2H2 Zn finger	518..537	CDD:275368	4/14 (29%)
		C2H2 Zn finger	545..565	CDD:275368
		zf-H2C2_2	557..582	CDD:290200
		C2H2 Zn finger	573..592	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930