DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF558

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_653294.1	Gene:	ZNF558 / 148156	HGNCID:	26422	Length:	402	Species:	Homo sapiens

Alignment Length:	271	Identity:	94/271 - (34%)
Similarity:	129/271 - (47%)	Gaps:	55/271 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 SQLGSRLNHSANFIYKCAVCPRVFAKSESLTRH------------------FSQAHKLTADVAAM 235
            |..|.:||       :|..|.:||:...:||:|                  ||....||..   .
Human   145 SHRGVKLN-------ECNQCFKVFSTKSNLTQHKRIHTGEKPYDCSQCGKSFSSRSYLTIH---K 199

  Fly   236 KLANESCGTGLLTCEHCPRTFKRQDTLRRHM------------QAFHPDAIALEPEETTDN-SAR 287
            ::.|   |.....|.||.:.|....:||.|:            |.||       ...|:.| .:.
Human   200 RIHN---GEKPYECNHCGKAFSDPSSLRLHLRIHTGEKPYECNQCFH-------VFRTSCNLKSH 254

  Fly   288 KRI---AKRRDCPHCGLSFPV-SSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERP 348
            |||   ....:|..||.:|.. ||||.|...|||:.||:|..|.|.|.:|..|:.|:|.||||:|
Human   255 KRIHTGENHHECNQCGKAFSTRSSLTGHNSIHTGEKPYECHDCGKTFRKSSYLTQHVRTHTGEKP 319

  Fly   349 SECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGES 413
            .||..|.|.|.|...|..|.|:|||::||.|..|.|:|...:.:|.|:|.||||:||:|..||:|
Human   320 YECNECGKSFSSSFSLTVHKRIHTGEKPYECSDCGKAFNNLSAVKKHLRTHTGEKPYECNHCGKS 384

  Fly   414 FVCGSHLNIHR 424
            |...|:|::|:
Human   385 FTSNSYLSVHK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	9/38 (24%)
		C2H2 Zn finger	249..266	CDD:275368	6/16 (38%)
		COG5048	<294..>391	CDD:227381	45/97 (46%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	12/22 (55%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	14/24 (58%)
		C2H2 Zn finger	407..424	CDD:275368	7/16 (44%)
ZNF558	NP_653294.1	KRAB	43..100	CDD:214630
		C2H2 Zn finger	154..174	CDD:275368	7/19 (37%)
		COG5048	<162..398	CDD:227381	86/247 (35%)
		C2H2 Zn finger	182..202	CDD:275368	4/22 (18%)
		C2H2 Zn finger	210..230	CDD:275368	7/19 (37%)
		C2H2 Zn finger	238..258	CDD:275368	7/26 (27%)
		C2H2 Zn finger	266..286	CDD:275368	9/19 (47%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930