DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF560

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_689689.2	Gene:	ZNF560 / 147741	HGNCID:	26484	Length:	790	Species:	Homo sapiens

Alignment Length:	471	Identity:	121/471 - (25%)
Similarity:	182/471 - (38%)	Gaps:	132/471 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 STSFA---EQHVEMEEKYGDQDCSAFTSDVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELSR 187
            |||.|   |.|: ::..|..::|       |::..|.:. .::..:....:||...:...:..:.
Human   332 STSHAVNVETHI-IKNPYECKEC-------GKDFRYPTH-LNNHMQTHIGIKPYKCKHCGKTFTV 387

  Fly   188 PSQLGSRL-NHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEH 251
            ||.....: .|:....|.|..|.:.|..|..|..|. :.|           |.|.    ...|:|
Human   388 PSGFLEHVRTHTGEKPYGCKECGKAFGTSAGLIEHI-RCH-----------AREK----TFKCDH 436

  Fly   252 CPRTFKRQDTLRRHM---------------QAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGL 301
            |.:.|....:|..|:               :||...:..:  |:...|:.:||.    ||..||.
Human   437 CGKAFISYPSLFGHLRVHNGEKPYEHKEYGKAFGTSSGVI--EDRRSNTGQKRF----DCDQCGK 495

  Fly   302 SF-PVSSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHT--------------------- 344
            .| ..|||..|:|.|||:.|:||.:|.|.|..|..|.:|||.||
Human   496 VFVSFSSLFAHLRTHTGEKPFKCYKCGKPFTSSACLRIHMRTHTEERLYQCKKCGKAFTKCSYLT 560

  Fly   345 -------GERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGE 402
                   ||:|.||..|.|.|..::.|.:|:|.|:|::||.||.|.|:|.:.:||..|:|||||:
Human   561 KHLRTHAGEKPYECMKCGKAFTERSYLTKHLRRHSGEKPYECKKCGKAFTERSDLTKHLRRHTGD 625

  Fly   403 RPYQCGVCGESFVCGS----HLNIHRNRK------------------GHLIAVIPGNEVEANFAA 445
            :||:...||::||..|    ||..|...|                  .||.........|.|...
Human   626 KPYEYKDCGKAFVVSSSLVDHLRTHTGYKPYKCNACEKAYSRSCVLTQHLKTHAAEKTSECNACG 690

  Fly   446 DPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHR 510
            :.:.|:.....|.:.:.::                  ||      |||..|      |...|.|.
Human   691 NSFRNSMCFHDRLKTLTKI------------------KP------YKCKDC------GKAFTCHS 725

  Fly   511 NKMSHYEIERVYENPF 526
            :..:|..| ...|.|:
Human   726 DLTNHVRI-HTGEKPY 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	6/20 (30%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	46/125 (37%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..358	CDD:290200	13/50 (26%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	7/20 (35%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	13..50	CDD:279668
		KRAB	110..161	CDD:214630
		KRAB	110..149	CDD:279668
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	323..342	CDD:275368	5/9 (56%)
		COG5048	344..754	CDD:227381	115/458 (25%)
		C2H2 Zn finger	350..370	CDD:275368	3/27 (11%)
		zf-H2C2_2	362..386	CDD:290200	2/24 (8%)
		C2H2 Zn finger	378..398	CDD:275368	2/19 (11%)
		C2H2 Zn finger	406..426	CDD:275368	6/20 (30%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..510	CDD:275368	9/19 (47%)
		zf-H2C2_2	502..527	CDD:290200	13/24 (54%)
		C2H2 Zn finger	518..538	CDD:275368	9/19 (47%)
		zf-H2C2_2	531..554	CDD:290200	6/22 (27%)
		C2H2 Zn finger	546..566	CDD:275368	0/19 (0%)
		zf-H2C2_2	558..582	CDD:290200	7/23 (30%)
		C2H2 Zn finger	574..594	CDD:275368	7/19 (37%)
		zf-H2C2_2	586..610	CDD:290200	11/23 (48%)
		zf-C2H2	600..622	CDD:278523	10/21 (48%)
		C2H2 Zn finger	602..622	CDD:275368	9/19 (47%)
		C2H2 Zn finger	630..650	CDD:275368	7/19 (37%)
		C2H2 Zn finger	658..678	CDD:275368	2/19 (11%)
		C2H2 Zn finger	714..734	CDD:275368	7/26 (27%)
		zf-H2C2_2	726..751	CDD:290200	4/16 (25%)
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	757..779	CDD:290200
		C2H2 Zn finger	770..790	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930