DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF491

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_689569.2	Gene:	ZNF491 / 126069	HGNCID:	23706	Length:	437	Species:	Homo sapiens

Alignment Length:	420	Identity:	109/420 - (25%)
Similarity:	161/420 - (38%)	Gaps:	101/420 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 YLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEP--------------LYASEDRDDEPEDSFQLK 174
            ::..|...:::..:..:....|..|.    |:|              .:.:.:|....|..|..|
Human    46 FMGYSSFNRNIRTDTGHQPHKCQKFL----EKPYKHKQRRKALSHSHCFRTHERPHTREKPFDCK 106

  Fly   175 PRPDEIENRELSRPSQLGSRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLAN 239
                |.|...:|..|.....:.||.:..|||..|.:..                  |..::.|.:
Human   107 ----ECEKSFISPASIRRYMVTHSGDGPYKCKFCGKAL------------------DCLSLYLTH 149

  Fly   240 ESCGTG--LLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLS 302
            |...||  ...|:.|.:.|....::|.|              |.|...     .|..:|..||.|
Human   150 ERTHTGEKRYECKQCGKAFSWHSSVRIH--------------ERTHTG-----EKPYECKECGKS 195

  Fly   303 FPV-SSLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLAR 366
            |.. ||...|.|.|||:.||||.:|.|||........|.|.||||:|.|||:..|.........|
Human   196 FNFSSSFRRHERTHTGEKPYKCKECGKAFNCPSSFHRHERTHTGEKPYECKLYGKALSRLISFRR 260

  Fly   367 HMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIH-RNRKGHL 430
            |||:|||:||:.||:|.|:|...:..:.|.|.||||:||:|..||::|.|.:....| |...|..
Human   261 HMRMHTGERPHKCKICGKAFYSPSSFQRHERSHTGEKPYKCKQCGKAFTCSTSFQYHERTHTGEK 325

  Fly   431 IAVIPG--NEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQLQQRLENLPKPDVPAMCYKC 493
                |.  .:....|.:..|:                       ::..|.....||      |:|
Human   326 ----PDGCKQCGKAFRSAKYI-----------------------RIHGRTHTGEKP------YEC 357

  Fly   494 GVCEQKFKSGALLTVHRNKMSHYEIERVYE 523
            ..|.:.|.  .:.:.||::.:|.. |:.||
Human   358 KQCGKAFH--CVSSFHRHERTHAG-EKPYE 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	2/20 (10%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	45/97 (46%)
		C2H2 Zn finger	296..315	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..330	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	11/22 (50%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	14/23 (61%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	6/17 (35%)
ZNF491	NP_689569.2	C2H2 Zn finger	42..59	CDD:275368	1/12 (8%)
		COG5048	<50..290	CDD:227381	77/284 (27%)
		C2H2 Zn finger	67..97	CDD:275368	5/33 (15%)
		C2H2 Zn finger	105..125	CDD:275368	5/23 (22%)
		C2H2 Zn finger	133..153	CDD:275368	5/37 (14%)
		C2H2 Zn finger	161..181	CDD:275368	6/33 (18%)
		C2H2 Zn finger	189..209	CDD:275368	9/19 (47%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		COG5048	<227..430	CDD:227381	57/194 (29%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		C2H2 Zn finger	329..349	CDD:275368	3/42 (7%)
		C2H2 Zn finger	357..377	CDD:275368	5/21 (24%)
		C2H2 Zn finger	385..405	CDD:275368	109/420 (26%)
		C2H2 Zn finger	413..433	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146624
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930