DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and PRDM5

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001366033.1	Gene:	PRDM5 / 11107	HGNCID:	9349	Length:	641	Species:	Homo sapiens

Alignment Length:	469	Identity:	120/469 - (25%)
Similarity:	180/469 - (38%)	Gaps:	149/469 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QTCR-----VC--------------LETHETNLYVHDEIKYNDLKLELWQLLEAVSKLKWTWTDP 58
            :|||     ||              |:.|:.|::..|..|                ||
Human   254 ETCRGDARFVCKADSCGKRLKSKDALKRHQENVHTGDPKK----------------KL------- 295

  Fly    59 NLPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQEVAAKPDEVHVDVVELIDQDDVVSMAQ 123
                 :|..|.::...|...     ..|..:..:|:.||                      .|.:
Human   296 -----ICSVCNKKCSSASSL-----QEHRKIHEIFDCQE----------------------CMKK 328

  Fly   124 YLSTSFAEQHVEMEEKYGDQDCSAFTSDVGEEPLYASEDRDDEPEDSFQLKPRP--DEIENRELS 186
            ::|.:..::|:...            ||:...||.            |.::.||  .||.|:...
Human   329 FISANQLKRHMITH------------SDMRLSPLI------------FLIEKRPYNCEICNKSFK 369

  Fly   187 RPSQLGS-RLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLT---------ADVAAMKLANES 241
            |..|:|: ::.||.:..|||.:|.:.||.     |:..:.||.|         .:..|:.....|
Human   370 RLDQVGAHKVIHSEDKPYKCKLCGKGFAH-----RNVYKNHKKTHSEERPFQCEECKALFRTPFS 429

  Fly   242 CGTGLL--------TCEHCPRTFKRQDTLRRHMQAFH-----------------PDAIALEPEET 281
            ....||        .|.||..||||:|||..|:|..|                 |.  .|...:.
Human   430 LQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPS--VLRSHKK 492

  Fly   282 TDNSARKRIAKRRDCPHCGLSFPVS-SLTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTG 345
            |....:::|     ||:||..|..| :|.:|||.|||:.||:|..|||.|.::..|.:|:|.||.
Human   493 THTGEKEKI-----CPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTR 552

  Fly   346 ERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPY-QCGV 409
            |:|.:|..|||.|..:..|..|.|.|||::|:.|.:|..:|.....|..|...|...||. :|..
Human   553 EKPYKCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPLAECQF 617

  Fly   410 CGESFVCGSHLNIH 423
            |.:.|....:|.:|
Human   618 CHKKFTRNDYLKVH 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	16/96 (17%)
		C2H2 Zn finger	205..226	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..266	CDD:275368	10/16 (63%)
		COG5048	<294..>391	CDD:227381	42/97 (43%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	13/22 (59%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	11/22 (50%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	10/23 (43%)
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		zf-H2C2_2	391..416	CDD:290200	8/25 (32%)
		C2H2 Zn finger	407..424	CDD:275368	5/17 (29%)
PRDM5	NP_001366033.1	PR-SET_PRDM5	2..128	CDD:380967
		COG5048	<145..338	CDD:227381	21/138 (15%)
		C2H2 Zn finger	169..190	CDD:275368
		C2H2 Zn finger	201..221	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368	0/1 (0%)
		COG5048	262..631	CDD:227381	116/459 (25%)
		C2H2 Zn finger	264..287	CDD:275368	4/22 (18%)
		C2H2 Zn finger	297..317	CDD:275368	4/24 (17%)
		C2H2 Zn finger	322..342	CDD:275368	5/41 (12%)
		C2H2 Zn finger	361..381	CDD:275368	6/19 (32%)
		C2H2 Zn finger	389..409	CDD:275368	7/24 (29%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
		C2H2 Zn finger	445..462	CDD:275368	10/16 (63%)
		C2H2 Zn finger	474..494	CDD:275368	2/21 (10%)
		C2H2 Zn finger	502..522	CDD:275368	10/19 (53%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	8/19 (42%)
		C2H2 Zn finger	586..606	CDD:275368	5/19 (26%)
		C2H2 Zn finger	615..636	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910