DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3281 and ZNF266

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001357303.1	Gene:	ZNF266 / 10781	HGNCID:	13059	Length:	616	Species:	Homo sapiens

Alignment Length:	399	Identity:	114/399 - (28%)
Similarity:	164/399 - (41%)	Gaps:	96/399 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 EEKYGDQDC------SAFTSDVGEEPLYASEDRDDEPEDSFQLKPRPDEIENRELSRPSQLGS-R 194
            |:.|..::|      ||:.:      ::......|.|.:..:.        .:..:|..||.. |
Human   276 EKPYKCKECGKGFRYSAYLN------IHMGTHTGDNPYECKEC--------GKAFTRSCQLTQHR 326

  Fly   195 LNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEHCPRTFKRQ 259
            ..|:....|||..|.|.|..|..|::|             ||:   ..|.....|:.|...|.|.
Human   327 KTHTGEKPYKCKDCGRAFTVSSCLSQH-------------MKI---HVGEKPYECKECGIAFTRS 375

  Fly   260 DTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVSS-LTIHIRRHTGDNPYKC 323
            ..|..|::..    .|.:|.|               |..||.||..|| |:.|.|.|||..||||
Human   376 SQLTEHLKTH----TAKDPFE---------------CKICGKSFRNSSCLSDHFRIHTGIKPYKC 421

  Fly   324 DQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQ 388
            ..|.|||.::.||:.|.|.|:||||.|||.|.|.|...::|:.|.|.|||::|:.|..|.|:|..
Human   422 KDCGKAFTQNSDLTKHARTHSGERPYECKECGKAFARSSRLSEHTRTHTGEKPFECVKCGKAFAI 486

  Fly   389 SNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARV 453
            |::|..|:|.||||:|::|..||::|...|.||               |.:..:.|..|:.
Human   487 SSNLSGHLRIHTGEKPFECLECGKAFTHSSSLN---------------NHMRTHSAKKPFT---- 532

  Fly   454 NQRRSEDIERMRLQRIPE-NQLQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSHYE 517
                  .:|..:..:.|. ..|..|:....||      |||..|.:.|.       :.|....:|
Human   533 ------CMECGKAFKFPTCVNLHMRIHTGEKP------YKCKQCGKSFS-------YSNSFQLHE 578

  Fly   518 IERVYENPF 526
            .....|.|:
Human   579 RTHTGEKPY 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	7/20 (35%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	48/97 (49%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	13/23 (57%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..358	CDD:290200	14/22 (64%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..424	CDD:275368	7/16 (44%)
ZNF266	NP_001357303.1	KRAB	39..95	CDD:214630
		C2H2 Zn finger	199..217	CDD:275370
		C2H2 Zn finger	225..245	CDD:275368
		C2H2 Zn finger	254..273	CDD:275368
		COG5048	277..616	CDD:227381	113/398 (28%)
		C2H2 Zn finger	281..301	CDD:275368	3/25 (12%)
		C2H2 Zn finger	309..329	CDD:275368	4/27 (15%)
		C2H2 Zn finger	337..357	CDD:275368	9/35 (26%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	10/19 (53%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	8/19 (42%)
		C2H2 Zn finger	505..525	CDD:275368	8/34 (24%)
		C2H2 Zn finger	533..553	CDD:275368	4/19 (21%)
		C2H2 Zn finger	561..581	CDD:275368	5/26 (19%)
		C2H2 Zn finger	589..609	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930