DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZBTB18

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_991331.1	Gene:	ZBTB18 / 10472	HGNCID:	13030	Length:	531	Species:	Homo sapiens

Alignment Length:	338	Identity:	77/338 - (22%)
Similarity:	121/338 - (35%)	Gaps:	94/338 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 QQEVAAKPDEVHVD-VVELIDQDDVVSMAQYLSTSFAEQHV---EMEEKYGDQDCSAFTSDVG-- 153
            |:.|.:..|...|| |::|..:..:..:....|:.|:.|.|   .:.:...:::.|...||||
Human   233 QRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTN 297

  Fly   154 ------------------------------EEPLYASEDRDDEPEDSFQLKPRPDEIENRELSRP 188
                                          |:.:....||:|:..|...:.|..:.::.......
Human   298 DYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMES 362

  Fly   189 SQLG--SRLNHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMKLANESCGTGLLTCEH 251
            |.|.  |.:...|..|:.|.:|.:||.....|..|.| .|....|....|.|.:   ..:.||..
Human   363 SLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLS-THFREQDGIRSKPAAD---VNVPTCSL 423

  Fly   252 CPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGLSFPVSSLTIHIRRHT 316
            |.:||....||:||.                                              |.|:
Human   424 CGKTFSCMYTLKRHE----------------------------------------------RTHS 442

  Fly   317 GDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKM 381
            |:.||.|.||.|:|..|.:||.|...||.|:|..||.|.::|.....|.||:      |.:.|::
Human   443 GEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHI------RKFHCEL 501

  Fly   382 CSKSFVQSNDLKI 394
            .:...|:|..|.:
Human   502 VNSLSVKSEALSL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	7/20 (35%)
		C2H2 Zn finger	249..266	CDD:275368	7/16 (44%)
		COG5048	<294..>391	CDD:227381	29/96 (30%)
		C2H2 Zn finger	296..315	CDD:275368	1/18 (6%)
		zf-H2C2_2	307..330	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..358	CDD:290200	10/22 (45%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	5/23 (22%)
		C2H2 Zn finger	379..399	CDD:275368	4/16 (25%)
		zf-H2C2_2	391..416	CDD:290200	1/4 (25%)
		C2H2 Zn finger	407..424	CDD:275368
ZBTB18	NP_991331.1	BTB	23..119	CDD:279045
		BTB	34..119	CDD:197585
		COG5048	<303..>490	CDD:227381	53/236 (22%)
		C2H2 Zn finger	381..401	CDD:275368	7/20 (35%)
		C2H2 Zn finger	421..441	CDD:275368	9/65 (14%)
		zf-H2C2_2	434..456	CDD:290200	12/67 (18%)
		C2H2 Zn finger	449..469	CDD:275368	9/19 (47%)
		C2H2 Zn finger	477..495	CDD:275368	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000