DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3281 and ZNF891

DIOPT Version :9

Sequence 1:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001264220.1	Gene:	ZNF891 / 101060200	HGNCID:	38709	Length:	544	Species:	Homo sapiens

Alignment Length:	449	Identity:	117/449 - (26%)
Similarity:	177/449 - (39%)	Gaps:	117/449 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KWTWTDPN-------LPMHLCQNCARRLIGAYEFIVEVENAHETLQNLFEQQEVAAK---PDEVH 106
            |..|.:|:       |.||   |.:..|...:| ..::...|:.....:.|...|.|   |.|:.
Human   128 KILWEEPSNAVKMIKLTMH---NWSSTLREDWE-CHKIRKQHKIPGGHWRQMIYAPKKTVPQELF 188

  Fly   107 VDVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSAFTSDVG-------EEPLYASEDRD 164
            .|..||.:...:.|...:..:.|..:|  .::.|.:..|....|.:.       .|.||.|.:.|
Human   189 RDYHELEENSKLGSKLIFSQSIFTSKH--CQKCYSEIGCLKHNSIINNYVKNSISEKLYESHECD 251

  Fly   165 D-----------EPEDSF---------QLKPRPDEIE--------NRE--------LSRPSQLGS 193
            .           :.|.::         .:.|.|:.:.        |::        |.:..|..:
Human   252 TTLWHFQRNQTVQKEYTYSKHGMHFTHNMFPVPNNLHMAQNACECNKDETLCHQSSLKKQGQTHT 316

  Fly   194 RLNHSANFI----------------------YKCAVCPRVFAKSESLTRHFSQAHKLTADVAAMK 236
            ...|..|..                      |:|..|.:||..|.:|.||. :.|
Human   317 EKKHECNQCGKAFKRISNLTLYKKSHMGEKQYECKECGKVFNDSSTLRRHV-RTH---------- 370

  Fly   237 LANESCGTGLLTCEHCPRTFKRQDTLRRHMQAFHPDAIALEPEETTDNSARKRIAKRRDCPHCGL 301
                 .|.....|..|.:.|.::.:|:.||:....:                   |..:|..||.
Human   371 -----TGEKPYECNQCGKAFSQKTSLKAHMRTHTGE-------------------KPYECNQCGK 411

  Fly   302 SFPVSS-LTIHIRRHTGDNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSECKICSKKFISQNKLA 365
            ||..|| |.:|.|.|||:..|:|.:|.|||..|..|.:|.:.||||...||..|.|.|...:.|.
Human   412 SFGTSSYLIVHKRIHTGEKLYECSECGKAFNTSSHLKVHKKIHTGENVYECSDCGKVFSGVSSLR 476

  Fly   366 RHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGESFVCGSHLNIHR 424
            .|:|.|||::||.||.|.|:|..|:.|:.|:|.||||:||:|..||::|...|.|.||:
Human   477 MHIRTHTGEKPYECKECRKAFSVSSSLRRHVRIHTGEKPYECIQCGKAFSQSSSLIIHK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	10/46 (22%)
		C2H2 Zn finger	205..226	CDD:275368	8/20 (40%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		COG5048	<294..>391	CDD:227381	45/97 (46%)
		C2H2 Zn finger	296..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	307..330	CDD:290200	11/23 (48%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..358	CDD:290200	10/22 (45%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	13/23 (57%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..424	CDD:275368	7/16 (44%)
ZNF891	NP_001264220.1	KRAB	43..99	CDD:214630
		KRAB	43..82	CDD:279668
		COG5048	<272..544	CDD:227381	87/299 (29%)
		C2H2 Zn finger	295..315	CDD:275368	3/19 (16%)
		C2H2 Zn finger	322..342	CDD:275368	1/19 (5%)
		zf-C2H2	348..370	CDD:278523	9/22 (41%)
		C2H2 Zn finger	350..370	CDD:275368	8/20 (40%)
		zf-H2C2_2	363..387	CDD:290200	8/39 (21%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	9/43 (21%)
		C2H2 Zn finger	406..426	CDD:275368	10/19 (53%)
		zf-H2C2_2	418..443	CDD:290200	12/24 (50%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		zf-H2C2_2	446..470	CDD:290200	10/23 (43%)
		C2H2 Zn finger	462..482	CDD:275368	7/19 (37%)
		zf-H2C2_2	474..498	CDD:290200	12/23 (52%)
		C2H2 Zn finger	490..510	CDD:275368	9/19 (47%)
		zf-H2C2_2	502..527	CDD:290200	13/24 (54%)
		C2H2 Zn finger	518..538	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930