DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and Pcdhb17

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_444372.2	Gene:	Pcdhb17 / 93888	MGIID:	2136754	Length:	799	Species:	Mus musculus

Alignment Length:	803	Identity:	186/803 - (23%)
Similarity:	304/803 - (37%)	Gaps:	247/803 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 DYFLLDAQTGELRTAKPLDREALEDSTGIIS-LVIRARELVNGVPSDDPLTSATAKATVTIRDVN 352
            ::..|:.|:|:|...:.||||.|   .|.|. .|:..:.|:     ::||  ...:|.:.:.|:|
Mouse    73 EHLQLNLQSGDLLINEKLDREEL---CGPIEPCVLHFQVLM-----ENPL--EVFQAELRVMDIN 127

  Fly   353 DSPPVFNHKEYSVSLLENTLPGTPLALDMSVSDADVGINSKFALRLDDVSGVFDVEPKLVTGYSQ 417
            |..|||:.:|..:.:|||:..|....|:.:: |:||.||:....||...|....|......|
Mouse   128 DYSPVFSEREMILRILENSALGDTFPLNNAL-DSDVAINNIQTYRLSSNSHFLVVTRNRSDG--- 188

  Fly   418 VNIRVANGTLDYENPNQRKFIVLVVAEETDTN----------------PRLSSTATITVSVLDAN 466
                             ||:..||:.:|.|..                |..|.||.:.:.|:|.|
Mouse   189 -----------------RKYPELVLEKELDREEEPELRLTLTALDGGAPPRSGTAQVLIEVVDIN 236

  Fly   467 DNKPVFEQESYSASVSEAALPGQYIATITARDVDSGSYGDSGIRYSLSGTGAEL---FHVNEQTG 528
            ||.|.|:|.:|...:.|.:..|..:.|::|.|:|||.||.  :.|:||....::   ..||..||
Mouse   237 DNAPKFQQPTYRVQIPENSPTGSLVLTVSANDLDSGDYGK--VLYALSQPSEDISKTLEVNPVTG 299

  Fly   529 VISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEE 593
            .|.|          |:|
Mouse   300 EIRL----------RKE------------------------------------------------ 306

  Fly   594 QASSVPLPAPVPHAAPSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRIS 658
                                             :|:|:..:|.:..||||  |.|.:...:|.:.
Mouse   307 ---------------------------------VDFETIPSYEVDIKATD--GGGLSGKCTLLLK 336

  Fly   659 VTDANDSPP-----VCESPLYRASVDEGAVVF-------------------DSPLIVKARDADTM 699
            |.|.||:.|     ...||:...|.||...||                   |.|.::|:...:..
Mouse   337 VVDVNDNAPEVMLSALTSPVPENSPDEVVAVFSVKDPDSANNGKMIASIEEDLPFLLKSSGKNFY 401

  Fly   700 SRISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTNLNSDQLIFAVEANDGLFTAHCGVNITV 764
            :.::.|.           :|||..:   :.|.|:.|::|.:.:|.          |.|. :.:.|
Mouse   402 TLVTKRA-----------LDREERE---KYNITITVSDLGTPRLT----------TQHT-ITVQV 441

  Fly   765 RDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRI-----QQGSFDD-FGI 823
            .|.|::.|.|.|.||:..|.||:.....:..:.|||.|.|.|:.:.|.:     .|.:.|. ..|
Mouse   442 SDTNDNAPAFNQTSYTLFVRENNSPAMHIGTISATDSDAGSNSHISYSLLPSHDPQLALDSLISI 506

  Fly   824 VETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEV- 887
            ....|::|..|.||::....::..:.|.|||:|:|:..|.:.:.|.:.||..|:.:...|::..
Mouse   507 NADNGQLFALRALDYEALQAFEFHVGAIDQGSPALSSQALVRVVVLDDNDNAPFVLYPMQNSSAP 571

  Fly   888 ------RADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKI-SR 945
                  || |.||.||..::|:|.|...:..|.|    .:....:.|           .|.: :.
Mouse   572 CTELLPRA-AEPGYLVTKVVAVDRDSGQNAWLSF----QLLKATEPG-----------LFSVWAH 620

  Fly   946 NGKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIK 1010
            ||:|...:.|........|:.:||.|:..| .:.....|.:.::|            ...||.:.
Mouse   621 NGEVRTTRLLSERDVPKHRLVLLVKDNGDP-PRSASVTLHVLVVD------------GFSQPYLP 672

  Fly  1011 LQMVEEQPVGTVLTTLQANDEDS 1033
            |..|...|         |:|||:
Mouse   673 LPEVARNP---------AHDEDA 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637	17/64 (27%)
		Cadherin_repeat	362..468	CDD:206637	29/121 (24%)
		Cadherin_repeat	476..>533	CDD:206637	19/59 (32%)
		E_set	<627..667	CDD:298831	14/39 (36%)
		CA	692..772	CDD:214520	15/79 (19%)
		Cadherin_repeat	778..873	CDD:206637	28/100 (28%)
		Cadherin_repeat	882..994	CDD:206637	26/119 (22%)
		Cadherin_repeat	1015..1099	CDD:206637	5/19 (26%)
		Cadherin_repeat	1108..1207	CDD:206637
		Cadherin_repeat	1215..1314	CDD:206637
		Cadherin_repeat	1327..1427	CDD:206637
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
Pcdhb17	NP_444372.2	Cadherin_2	33..112	CDD:285466	13/46 (28%)
		Cadherin_repeat	137..238	CDD:206637	29/121 (24%)
		Cadherin_repeat	246..343	CDD:206637	35/191 (18%)
		Cadherin_repeat	356..447	CDD:206637	22/115 (19%)
		Cadherin_repeat	455..557	CDD:206637	29/101 (29%)
		Cadherin_repeat	576..664	CDD:206637	24/104 (23%)
		Cadherin_C_2	687..770	CDD:293101	186/803 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000