DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and Cdhr1

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_446024.1	Gene:	Cdhr1 / 93662	RGDID:	620420	Length:	859	Species:	Rattus norvegicus

Alignment Length:	1073	Identity:	268/1073 - (24%)
Similarity:	417/1073 - (38%)	Gaps:	312/1073 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPLGLLMICLGLTLAKGETNLPPVF-----TQTLNNIILY---ENVTVGTVVFRLEAYDPEGSPV 59
            |.||||.|.|      .:.|..|.|     ..|..|:.|:   |:..||:.|:.|...||||.|:
  Rat     9 LVLGLLCIYL------AQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPI 67

  Fly    60 TYGAIGADH-----FSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPIT 119
            :| .|..|.     |||||..|||||::.||||.:|.::.::||.|.:         |:|...:.
  Rat    68 SY-HISFDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGL---------NLVAEKVV 122

  Fly   120 FIILDLNDNPPEFQNTPYEADVNEDAAVGTTIFDKITVKDRDIVGESLDLKCLPQQQSPEACRKF 184
            .::.|.||..|.|...||...|.|:...|::|| |:..:|:| .|....:....|.
  Rat   123 IVVTDANDEAPRFLQEPYNILVPENTPAGSSIF-KVQAEDKD-TGSGGSVTYFLQS--------- 176

  Fly   185 RLH----IIKRDATILEAAVVLNDTLNYNQRMVYHFQIEATDGPHKTQ---------TTFEARVK 236
             ||    .:.|.:.:|.  :....||:|.:...:...:.|.||..:.:         ||....|:
  Rat   177 -LHSSKFTVDRHSGVLR--LQAGATLDYEKSRAHFITVVAKDGGGRLRGADVVFSATTTVTINVE 238

  Fly   237 DVQDKPPVFQGS-LSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDLRTNPNDYFLLDAQTGE- 299
            ||||..|:|.|: ....:.||:...:.||||.|.|||.|:|..|:|.|....:..|.::..:|.
  Rat   239 DVQDTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNESDGLFEINETSGAI 303

  Fly   300 --LRTAKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVF---- 358
              |::...|.||..|       |.::..| ||.  |..|...:|....:.|.|:|:.||.|
  Rat   304 SVLQSPAQLRREVYE-------LHVQVTE-VNS--SGSPAAQSTVPVIIRIVDLNNHPPTFYGES 358

  Fly   359 -NHKEYSVSLLENTLPGTPL-ALDMSVSDADVGINSKFALRLDDVSGVFDVEPKLVTGYSQVNIR 421
             ...::.:|:.|:...|..| .|.::|:|:|.|.|:||.|||....|:|.|.|:.|...:||.|.
  Rat   359 GPQNKFELSMFEHPPQGEILRGLKITVNDSDQGANAKFNLRLVGPGGIFRVVPQTVLNEAQVTII 423

  Fly   422 VAN-GTLDYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAA 485
            |.| ..:|:|......|.:|.:  |.:|..:.||||.|.:.:||.|||.|.|....|.|.:.|..
  Rat   424 VENSAAIDFEKSKSLTFKLLAI--EVNTPEKFSSTADIVIQLLDTNDNVPKFTSHYYIARIPENV 486

  Fly   486 LPGQYIATITARDVDSGSYGDSGIRYSLSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLN 550
            ..|..:..:||.|.|:|.:|.  ::||:.|||::||.::..||:|
  Rat   487 PGGSNVVAVTAVDPDTGPWGK--VQYSIYGTGSDLFLIHPSTGLI-------------------- 529

  Fly   551 EDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPSGVPAA 615
                                             ||
  Rat   530 ---------------------------------YT------------------------------ 531

  Fly   616 TANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDE 680
                  .|...||.|..:.|....||.|.:||  .|:..:.:::.|.||     ..|.:..||.|
  Rat   532 ------QPWASLDAEGTSRYNFYVKAEDMDGR--YSLAEVFVTLLDVND-----HYPQFVQSVQE 583

  Fly   681 GAVVFDSPLIVKARDADT---MSRISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTNLNSDQ 742
            ..:|..:||.::|.|.|.   .:.:.|.|..:|.| ::||||..||:|.::          ||
  Rat   584 KTMVLGTPLKIEATDQDAEEPNNLVDYSITRAEPV-NVFDIDAHTGEIRLK----------NS-- 635

  Fly   743 LIFAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNA 807
             |.::||                 ::|..|:.|   ||
  Rat   636 -IRSLEA-----------------LHNITPSGE---YS--------------------------- 652

  Fly   808 ELRYRIQQGSFDDFGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQN-- 870
                                                :.||:||.|:|:||.:.||.|.|::.:
  Rat   653 ------------------------------------WSLQVQAKDRGSPSFSTTALLKIDITDTE 681

  Fly   871 --SNDKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDI----TAIDKEGK 929
              |......|:..|:...::|......::..::|:...::.........::.:    ..:.:...
  Rat   682 RLSRSSMAAFLIQTKDNPMKAVGVLAGVMAIVVAITVLISTATFWRNKKSNKVLPVRRVLRRRPS 746

  Fly   930 ELPHYDQFKEYFKISRNGKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGR-GLLIIQIIDVNK 993
            ..||..:. |:.|..|....|.              .:|..|....|....| |:.:
  Rat   747 PAPHTVRI-EWLKFRRAKAASK--------------FILKEDPPNENCNNSRVGVTV-------- 788

  Fly   994 NPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTL 1026
             |||  ||.....|::....|.:|.|.||..:|
  Rat   789 -PPR--APALPPPPKMASSTVAQQTVPTVSGSL 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	37/102 (36%)
		Cadherin_repeat	136..240	CDD:206637	27/116 (23%)
		Cadherin_repeat	248..353	CDD:206637	31/108 (29%)
		Cadherin_repeat	362..468	CDD:206637	39/107 (36%)
		Cadherin_repeat	476..>533	CDD:206637	20/56 (36%)
		E_set	<627..667	CDD:298831	13/39 (33%)
		CA	692..772	CDD:214520	20/82 (24%)
		Cadherin_repeat	778..873	CDD:206637	15/98 (15%)
		Cadherin_repeat	882..994	CDD:206637	14/116 (12%)
		Cadherin_repeat	1015..1099	CDD:206637	5/12 (42%)
		Cadherin_repeat	1108..1207	CDD:206637
		Cadherin_repeat	1215..1314	CDD:206637
		Cadherin_repeat	1327..1427	CDD:206637
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
Cdhr1	NP_446024.1	Cadherin_repeat	42..130	CDD:206637	34/97 (35%)
		Cadherin_repeat	139..242	CDD:206637	27/116 (23%)
		Cadherin_repeat	251..350	CDD:206637	32/108 (30%)
		Cadherin_repeat	364..469	CDD:206637	39/106 (37%)
		Cadherin_repeat	478..573	CDD:206637	36/192 (19%)
		Cadherin_repeat	580..679	CDD:206637	42/195 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..859		12/32 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010