Protein Alignment Cad87A and CDHR1

DIOPT Version :9

• Sequence 1: NP_731649.2
• Gene: Cad87A / 41441
• FlyBaseID: FBgn0037963
• Length: 1975
• Species: Drosophila melanogaster
• Sequence 2: XP_011538639.1
• Gene: CDHR1 / 92211
• HGNCID: 14550
• Length: 917
• Species: Homo sapiens
• Alignment Length: 944
• Identity: 247/944 - (26%)
• Similarity: 382/944 - (40%)
• Gaps: 276/944 - (29%)

  Fly     5 LGLLMICLGL----TLAKGETNLPPVF-----TQTLNNIILY---ENVTVGTVVFRLEAYDPEGS 57
            ||:|  |||:    .|...:.|..|.|     ..|..|:.|:   |:..||:.|:.|...||||.
Human    61 LGVL--CLGVRLFCVLFPAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGD 123

  Fly    58 PVTYGAIGADH-----FSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVP 117
            |::| .|..|.     |||||..|||||::.||||.:|.::.::||.|.:         |:|...
Human   124 PISY-HISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGL---------NLVAEK 178

  Fly   118 ITFIILDLNDNPPEFQNTPYEADVNEDAAVGTTIFDKITVKDRDIVGESLDLKCLPQQQSPEACR 182
            :..::.|.||..|.|...||.|.|.||...|:.|| |:...|||..........|....||.|
Human   179 VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF-KVHAVDRDTGSGGSVTYFLQNLHSPFA-- 240

  Fly   183 KFRLHIIKRDATILEAAVVLNDTLNYNQRMVYHFQIEATDGPHK---------TQTTFEARVKDV 238
                  :.|.:.:|.  :....||:|.:...::..:.|.||..:         ..||....|:||
Human   241 ------VDRHSGVLR--LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDV 297

  Fly   239 QDKPPVFQGS-LSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDLRTNPND-YFLLDAQTGELR 301
            ||..|||.|: ....:.||:...:.||.|.|.|||.|:|.:|:|.| .|.|| .|.::..:|.:.
Human   298 QDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSL-VNGNDGAFEINETSGAIS 361

  Fly   302 -TAKP--LDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVF----- 358
             |..|  |.||..|       |.::..|:   .|:..|...||...|:.|.|:|:.||.|
Human   362 ITQSPAQLQREVYE-------LHVQVTEM---SPAGSPAAQATVPVTIRIVDLNNHPPTFYGESG 416

  Fly   359 NHKEYSVSLLENTLPGTPL-ALDMSVSDADVGINSKFALRLDDVSGVFDVEPKLVTGYSQVNIRV 422
            ....:.:|:.|:...|..| .|.::|:|:|.|.|:||.|:|....|:|.|.|:.|...:||.|.|
Human   417 PQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIV 481

  Fly   423 AN-GTLDYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAAL 486
            .| ..:|:|......|.:|.|  |.:|..:.||||.:.:.:||.|||.|.|:...|.|.:.|.|.
Human   482 ENSAAIDFEKSKVLTFKLLAV--EVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAP 544

  Fly   487 PGQYIATITARDVDSGSYGDSGIRYSLSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLNE 551
            .|..:..:||.|.|:|.:|:  ::||..||||:||.::..||:|
Human   545 GGSSVVAVTAVDPDTGPWGE--VKYSTYGTGADLFLIHPSTGLI--------------------- 586

  Fly   552 DEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPSGVPAAT 616
                                            ||
Human   587 --------------------------------YT------------------------------- 588

  Fly   617 ANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDEG 681
                 .|...||.|:...|....||.|..|:  .||..:.|::.|.||.|     |.:..||.:.
Human   589 -----QPWASLDAEATARYNFYVKAEDMEGK--YSVAEVFITLLDVNDHP-----PQFGKSVQKK 641

  Fly   682 AVVFDSPLIVKARDADT---MSRISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTNLNSDQL 743
            .:|..:|:.::|.|.|.   .:.:.|.|..:|.. ::|||:..||:|.::          ||
Human   642 TMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPA-NVFDINSHTGEIWLK----------NS--- 692

  Fly   744 IFAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAE 808
                                :|                          |::.:|  ::..|::.
Human   693 --------------------IR--------------------------SLDALH--NITPGRDC- 708

  Fly   809 LRYRIQQGSFDDFGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSN- 872
                                              .:.|::||.|:|:||.:.||.|.|::.::.
Human   709 ----------------------------------LWSLEVQAKDRGSPSFSTTALLKIDITDAET 739

  Fly   873 -DKDPY--FVPATQHAEVRADAPPGQLVYTLIAL 903
             .:.|.  |:..|:...::|.......:.|::|:
Human   740 LSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAI 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	37/102 (36%)
		Cadherin_repeat	136..240	CDD:206637	30/112 (27%)
		Cadherin_repeat	248..353	CDD:206637	34/109 (31%)
		Cadherin_repeat	362..468	CDD:206637	38/107 (36%)
		Cadherin_repeat	476..>533	CDD:206637	22/56 (39%)
		E_set	<627..667	CDD:298831	14/39 (36%)
		CA	692..772	CDD:214520	15/82 (18%)
		Cadherin_repeat	778..873	CDD:206637	14/96 (15%)
		Cadherin_repeat	882..994	CDD:206637	4/22 (18%)
		Cadherin_repeat	1015..1099	CDD:206637
		Cadherin_repeat	1108..1207	CDD:206637
		Cadherin_repeat	1215..1314	CDD:206637
		Cadherin_repeat	1327..1427	CDD:206637
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
CDHR1	XP_011538639.1	Cadherin_repeat	100..188	CDD:206637	34/97 (35%)
		Cadherin_repeat	197..299	CDD:206637	30/112 (27%)
		Cadherin_repeat	308..407	CDD:206637	35/109 (32%)
		Cadherin_repeat	421..526	CDD:206637	38/106 (36%)
		Cadherin_repeat	535..630	CDD:206637	38/187 (20%)
		Cadherin_repeat	646..737	CDD:206637	30/187 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010