Protein Alignment Cad87A and PCDH11Y

DIOPT Version :10

• Sequence 1: NP_731649.2
• Gene: Cad87A / 41441
• FlyBaseID: FBgn0037963
• Length: 1975
• Species: Drosophila melanogaster
• Sequence 2: NP_116755.1
• Gene: PCDH11Y / 83259
• HGNCID: 15813
• Length: 1340
• Species: Homo sapiens
• Alignment Length: 1144
• Identity: 266/1144 - (23%)
• Similarity: 435/1144 - (38%)
• Gaps: 322/1144 - (28%)

  Fly   440 LVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAALPGQYIATITARDVDSGSY 504
            |:::..:..:|.|      .|||:..|           :.:..:..|.|.||..:....|
Human     7 LIISSSSSLSPLL------LVSVVRVN-----------TTNCHKCLLSGTYIFAVLLVCV----- 49

  Fly   505 GDSGIRYSLSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSM 569
                           :||...|             |.|...|.::.|:..:.....:.:|.::..
Human    50 ---------------VFHSGAQ-------------EKNYTIREEIPENVLIGNLLKDLNLSLIPN 86

  Fly   570 EAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPSGVPAATANDDK------APQTCLD 628
            ::.|      .|:|:.|:     .:...|||..............|..:.:|      ..:.|.
Human    87 KSLT------TTMQFKLV-----YKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCF- 139

  Fly   629 YESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVKA 693
            ||.|....     .|:..|    :|.:|..:.|.||:.|:..:.:...|:.|.:.:.....:..|
Human   140 YEVEVAIL-----PDEIFR----LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAA 195

  Fly   694 RDADTMSRISYRIRGSEQVE-----SIFDID-------RETGQIIIRPNATLDVTNLNSDQLIFA 746
            .|.|.      .|.|.:..|     :||.:|       .:..|:|::.    ::.....|..:..
Human   196 VDPDV------GINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQK----ELDREEKDTYVMK 250

  Fly   747 VEANDGLFTAHCG---VNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAE 808
            |:..||.|.....   :.::|.|.|::.|.|::......:.||:.:||||.::||||.|.|:||:
Human   251 VKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAK 315

  Fly   809 LRYRIQQGSFDD---------FGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATL 864
            :.:     ||.:         |.:..|||.:.:...||.:....::|.:.|||.|.  :...|.:
Human   316 IHF-----SFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGL--MPARAMV 373

  Fly   865 TINVQNSNDKDP-----YFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAI 924
            .:||.:.||..|     |.|.......|.::..|......||.:....|:||......||
Human   374 LVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTD----- 433

  Fly   925 DKEGKELP-------------------HYDQFKEYFKISRNGKVSVNKQLDRNLFAVMRINVLVT 970
                .|:|                   .|:..|||                       .|.:|..
Human   434 ----HEIPFRLRPVFSNQFLLENAAYLDYESTKEY-----------------------AIKLLAA 471

  Fly   971 DSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDSSI 1035
            |:..|.:.|. .:|.|::.|.|.|.|.|.      |..:.:.:.|....|..|..:.|.|.||..
Human   472 DAGKPPLNQS-AMLFIKVKDENDNAPVFT------QSFVTVSIPENNSPGIQLMKVSATDADSGP 529

  Fly  1036 GEFNISDNDY---------FAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVV 1091
            .    ::.:|         |::::.:||:..:.:||.|...:..|.:...|.|||.||:...|.|
Human   530 N----AEINYLLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFV 590

  Fly  1092 DIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYFSIDAYT 1156
            .||:.|||.|.|:.::|.|.|.||.||....|.:...|.|.|....:|.:::.||:. |:||:.|
Human   591 SIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQT 654

  Fly  1157 GNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYN---- 1217
            | |:..|.| .|||:.:..|..|.|:|  ...|.:|::|.:.||::|||||.|||....||
Human   655 G-VIRPNIS-FDREKQESYTFYVKAED--GGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYE 715

  Fly  1218 ----STVAENAAYQPPAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSG 1278
                ||       .|...:.||.|:|.|.|:..:|||.|..||...||.:|.::|.:    :|..
Human   716 LVLPST-------NPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNI----TLME 769

  Fly  1279 K-----HGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNAT---------IE 1329
            |     .|.:.:.:.|.|.   |..:|....:|..|.||.        :::|||         ||
Human   770 KCDVTDLGLHRVLVKANDL---GQPDSLFSVVIVNLFVNE--------SVTNATLINELVRKSIE 823

  Fly  1330 IP-------GDIVQP--DYLLLTVRAMDNDTEENGKVSY----------------HLQVNNRNEQ 1369
            .|       .|:..|  ||:.:.|.|:      .|.::.                ||:...:| .
Human   824 APVTPNTEIADVSSPTSDYVKILVAAV------AGTITVVVVIFITAVVRCRQAPHLKAAQKN-M 881

  Fly  1370 QTGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSI-------VDANEN 1427
            |..|:...  ..|.|....:.:|.:         :...:|  ::|.|..|:|       ||::.|
Human   882 QNSEWATP--NPENRQMIMMKKKKK---------KKKHSP--KNLLLNVVTIEETKADDVDSDGN 933

  Fly  1428 R---------------------------PEFPDASNPYK 1439
            |                           |:.||.:..||
Human   934 RVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHYK 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637	7/27 (26%)
		Cadherin_repeat	476..>533	CDD:206637	8/56 (14%)
		CA_like	<627..667	CDD:481204	10/39 (26%)
		CA	692..772	CDD:214520	19/94 (20%)
		Cadherin_repeat	778..873	CDD:206637	30/103 (29%)
		Cadherin_repeat	882..994	CDD:206637	24/130 (18%)
		Cadherin_repeat	1015..1099	CDD:206637	26/92 (28%)
		Cadherin_repeat	1108..1207	CDD:206637	37/98 (38%)
		Cadherin_repeat	1215..1314	CDD:206637	32/111 (29%)
		Cadherin_repeat	1327..1427	CDD:206637	26/140 (19%)
		Cadherin_repeat	1437..1549	CDD:206637	2/3 (67%)
		Cadherin_repeat	1557..1662	CDD:206637
PCDH11Y	NP_116755.1	Cadherin_2	60..134	CDD:462413	12/84 (14%)
		Cadherin_repeat	175..277	CDD:206637	21/111 (19%)
		Cadherin_repeat	285..383	CDD:206637	31/104 (30%)
		CA	416..496	CDD:214520	21/112 (19%)
		Cadherin_repeat	504..598	CDD:206637	26/97 (27%)
		Cadherin_repeat	606..701	CDD:206637	37/99 (37%)
		Cadherin_repeat	713..804	CDD:206637	28/104 (27%)
		Protocadherin	807..1008	CDD:462451	35/186 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1052..1112
		FAM47	<1180..1247	CDD:405345
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1321..1340