DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and FAT4

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_001278232.1 Gene:FAT4 / 79633 HGNCID:23109 Length:4983 Species:Homo sapiens


Alignment Length:1970 Identity:507/1970 - (25%)
Similarity:818/1970 - (41%) Gaps:411/1970 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 PPVFTQTLNNIILYENVTVGTVVFRLEAYD-PEGSP--VTYGAI-GA-DHFSVDPVSGNITLIKP 83
            ||||...:.::.:.||:..|:.:.:|.|.| .||:.  |||..| || |.|.:||.||::...:.
Human  1737 PPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRR 1801

  Fly    84 LDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDNPPEFQNTPYEADVNEDAAVG 148
            ||||.:.....||    |.| :|....|..:.:.::    |:||:.|:|....|..|:.||...|
Human  1802 LDRERRSKYSLLV----RAD-DGLQSSDMRINITVS----DVNDHTPKFSRPVYSFDIPEDTIPG 1857

  Fly   149 TTIFDKI-TVKDRDIVGESLDLKCLPQQQSPEACRKFRLHIIKRD-------ATILEAAVVLNDT 205
            :.:...: |..|..:.||.                   .:|:..|       ...:.....|...
Human  1858 SLVAAILATDDDSGVNGEI-------------------TYIVNEDDEDGIFFLNPITGVFNLTRL 1903

  Fly   206 LNYNQRMVYHFQIEATDGPHKTQTTFEA--RVKDVQDKPPVFQ-GSLSTVIDEDSPINTLVLTVH 267
            |:|..:..|...:.|.||..:. ||...  .:.||.|.||:|. .|.||.:.|:.|:.:.||..:
Human  1904 LDYEVQQYYILTVRAEDGGGQF-TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFN 1967

  Fly   268 ARDGDTGEPRKIVYDLRTNPN-DYFLLDAQTGELRTAKPLDREALEDSTGIISLVIRARELVNGV 331
            ..|.|.|...::.|.:.:..: ..|.:| :.|.|:..|.||||    |....:||::..:|.. :
Human  1968 VTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRE----SQSFYNLVVQVHDLPQ-I 2026

  Fly   332 PSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSLLENTLPGTPLALDMSVSDADVGINS---- 392
            |:.  ..::||:.::.:.||||:||.|...:.:. :.||| |...:......:|.|.|.||    
Human  2027 PAS--RFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENT-PIDTVVFKAQATDPDSGPNSYIEY 2087

  Fly   393 --------KFALRLDDVSGVFDVEPKLVTGYSQVNIRVANGTLDYENPNQRKFIVLVVAEETDT- 448
                    ||::      |..|.|.:|            .|.||.|..:  .:.:.|||  ||. 
Human  2088 TLLNPLGNKFSI------GTIDGEVRL------------TGELDREEVS--NYTLTVVA--TDKG 2130

  Fly   449 NPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAALPGQYIATITARDVDSGSYGDSGIRYSL 513
            .|.|||:..:.|.|||.|||.|:|.|..|...::|..|.|..|..:.|.|.|.|:.|.  :||.:
Human  2131 QPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQ--VRYGI 2193

  Fly   514 -SGTGAELFHVNEQTGVISLA---------------NCHDNGESNRRERR-------DLNE---- 551
             :|...:.|.::..||.|::|               ...|.|.:.|.:..       |:|:    
Human  2194 VNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPV 2258

  Fly   552 ------DEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPS 610
                  ..:|.|:.|.....:|.:.|...:.|:...:.|.|. ...|:.|.::         :.|
Human  2259 FELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLF-GGNEDNAFTL---------SAS 2313

  Fly   611 GVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYR 675
            |....|.:        ||.|::..:.|...|||..........::.:.|.|.||:.|...|..|.
Human  2314 GELGVTQS--------LDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYF 2370

  Fly   676 ASVDEGAVVFDSPLIVKARDADTMSR--ISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTNL 738
            .::.|.|......|:|.|.|||....  |||||.|.   .|.|.|:..|||||  .:|.||  ..
Human  2371 TTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGG---NSQFTINPSTGQII--TSALLD--RE 2428

  Fly   739 NSDQLIFAVEANDG----LFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHAT 799
            ..|.....|..:|.    ..::...|.:||.|||::.|.|:...|...:...:..|:.|..|..|
Human  2429 TKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVT 2493

  Fly   800 DLDTGKNAELRYRI------------------------------------QQGSF---------- 818
            |.|.|.|:||.|.:                                    ..|||          
Human  2494 DADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTDSTTVTV 2558

  Fly   819 -----------------------------------------------------DDFGIVETTGEV 830
                                                                 :.|.|.:.||:|
Human  2559 RFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQV 2623

  Fly   831 FVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQ 895
            .:|:.|||::...|.:.|:|.|.|.|..:....|.|.|.:.||..|.|......:|:..:..|.:
Human  2624 SISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRK 2688

  Fly   896 LVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISR-NGKVSVNKQLDRNL 959
            :: |:.|:|.|...:..|::    :|...:.|..           |.|:. .|::...:.|||..
Human  2689 IL-TVSAMDKDSGPNGQLDY----EIVNGNMENS-----------FSINHATGEIRSVRPLDREK 2737

  Fly   960 FAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLT 1024
            .:...:.:..:|..:|: |.....::|.|:|.|.|.|||:..:|...|       |..|:|..:|
Human  2738 VSHYVLTIKSSDKGSPS-QSTSVKVMINILDENDNAPRFSQIFSAHVP-------ENSPLGYTVT 2794

  Fly  1025 TLQANDED---SSIGEFNISDNDY-FAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTA 1085
            .:..:|||   ::|..::|.|... |.||.::|.|.....|:.|.....:.:|:..|:|   .|.
Human  2795 RVTTSDEDIGINAISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTV 2856

  Fly  1086 TADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYF 1150
            :.||.:.:.::|||.|:||::.||.:..|.:..|:...:|.|.|.|.|..|::.| .|...::||
Human  2857 STDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFY-FIKSQSEYF 2920

  Fly  1151 SIDAYTGNVMVANSSILDRE--------QIKELTLSVVAQDKA-PAAVQKSATATIHINILDVND 1206
            .|:|.||.:.  |..||..:        .|...:..|.:.|:. |:.:.::   |:.|||:|.||
Human  2921 RINATTGEIF--NKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISET---TVTINIVDSND 2980

  Fly  1207 NAPVFTRDVYNSTVAENAAYQPPAALLQVQAI-DQDEGLYGDVRYIITAGNEMGLFKLDAQSGIV 1270
            |||.|.:..|.:.|.:|.  :....|::|.|| |:|.||..:|.|.|:..|.:|.||||..:|.:
Human  2981 NAPQFLKSKYFTPVTKNV--KVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWI 3043

  Fly  1271 YPAQSL-SGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIEIP--- 1331
            ..|.|| |..:..:.:|::|:| :|:..:.|.....|||...|.|.|||   :.|:.:..||   
Human  3044 SVASSLISDLNQNFFITVTAKD-KGNPPLSSQATVHITVTEENYHTPEF---SQSHMSATIPESH 3104

  Fly  1332 --GDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNR 1394
              |.||:      ||.|.|.|...||.:.|  .:::.||:  |.|.|:..||.|.....|:.:..
Human  3105 SIGSIVR------TVSARDRDAAMNGLIKY--SISSGNEE--GIFAINSSTGILTLAKALDYELC 3159

  Fly  1395 ANYDIILVARDAGNPPFESLRLLSVSIVDANENRPEFPDASNPYKVSINENSGRDVKIGHIQAAS 1459
            ..:::.:.|.|.|.........::|:::|.|:|.|.|  .|:.|..::.||:.....:.|:.|..
Human  3160 QKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVF--LSDDYFPTVLENAPSGTTVIHLNATD 3222

  Fly  1460 RSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADLHISEEERAS 1524
            .......:..|.:..::...|.:|..||.|.|...||.|....|.|    ::|| .::.:|||.|
Human  3223 ADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHL----TVKA-FNVPDEERCS 3282

  Fly  1525 FSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNATDADQGKNAKIE 1589
            |           |.|.|.:...|:..|.|...:||..::..|..|..:..|.|:|.|.|.:.::.
Human  3283 F-----------ATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVH 3336

  Fly  1590 FMIVASNLYKFGATKSTGSIVPSPFAIS-QDGRISANTIMAEYNQDRFELEIVARELEQPQSS-- 1651
            ::|       ||.::..|      |.|: :.|:|..:.|:....::|..|:::|:.....:.:  
Human  3337 YLI-------FGNSRKKG------FQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADI 3388

  Fly  1652 ASTKVNIWVFDGTQLVRVILSRPP---EEVYQEQEEIIAELRNATQHRIIVDEIRFHLDSIGRIR 1713
            ....||:.|.|...        ||   ..:|..|   |:|......|...|.  .|..|||    
Human  3389 DEVTVNVTVLDAND--------PPIFTLNIYSVQ---ISEGVPIGTHVTFVS--AFDSDSI---- 3436

  Fly  1714 MDWCDL-YF---------HAVDPQTQQIAPVDEILKDIDRNYDYLKDYYAGFAIENVVPAY--IA 1766
            ..|... ||         .:::|||.||.    :..::||               ..:|.|  ..
Human  3437 PSWSRFSYFIGSGNENGAFSINPQTGQIT----VTAELDR---------------ETLPIYNLSV 3482

  Fly  1767 IVQDEFDLAVAGLVALVIVL 1786
            :..|....:..|..:|::.|
Human  3483 LAVDSGTPSATGSASLLVTL 3502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 32/99 (32%)
Cadherin_repeat 136..240 CDD:206637 22/113 (19%)
Cadherin_repeat 248..353 CDD:206637 29/105 (28%)
Cadherin_repeat 362..468 CDD:206637 33/118 (28%)
Cadherin_repeat 476..>533 CDD:206637 17/57 (30%)
CA_like <627..667 CDD:481204 11/39 (28%)
CA 692..772 CDD:214520 30/85 (35%)
Cadherin_repeat 778..873 CDD:206637 33/193 (17%)
Cadherin_repeat 882..994 CDD:206637 22/112 (20%)
Cadherin_repeat 1015..1099 CDD:206637 24/87 (28%)
Cadherin_repeat 1108..1207 CDD:206637 31/107 (29%)
Cadherin_repeat 1215..1314 CDD:206637 34/100 (34%)
Cadherin_repeat 1327..1427 CDD:206637 28/104 (27%)
Cadherin_repeat 1437..1549 CDD:206637 28/111 (25%)
Cadherin_repeat 1557..1662 CDD:206637 24/107 (22%)
FAT4NP_001278232.1 Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 899..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637
Cadherin_repeat 1105..1206 CDD:206637
Cadherin_repeat 1215..1311 CDD:206637
Cadherin_repeat 1321..1416 CDD:206637
Cadherin_repeat 1428..1525 CDD:206637
Cadherin_repeat 1540..1622 CDD:206637
Cadherin_repeat 1634..1736 CDD:206637
Cadherin_repeat 1747..1837 CDD:206637 32/98 (33%)
Cadherin_repeat 1845..1940 CDD:206637 22/114 (19%)
Cadherin_repeat 1948..2047 CDD:206637 30/106 (28%)
Cadherin_repeat 2057..2150 CDD:206637 33/116 (28%)
Cadherin_repeat 2159..2254 CDD:206637 22/96 (23%)
Cadherin_repeat 2263..2360 CDD:206637 23/114 (20%)
Cadherin_repeat 2369..2464 CDD:206637 35/101 (35%)
Cadherin_repeat 2472..2559 CDD:206637 15/86 (17%)
Cadherin_repeat 2573..2667 CDD:206637 19/93 (20%)
Cadherin_repeat 2675..2771 CDD:206637 22/112 (20%)
Cadherin_repeat 2778..2870 CDD:206637 26/101 (26%)
Cadherin_repeat 2878..2981 CDD:206637 31/108 (29%)
Cadherin_repeat 2990..3085 CDD:206637 33/97 (34%)
Cadherin_repeat 3095..3192 CDD:206637 28/106 (26%)
Cadherin_repeat 3201..3295 CDD:206637 27/109 (25%)
Cadherin_repeat 3305..3402 CDD:206637 25/109 (23%)
Cadherin_repeat 3410..3508 CDD:206637 26/121 (21%)
Cadherin_repeat 3516..3612 CDD:206637
EGF_CA 3864..3900 CDD:238011
EGF_CA 3902..3938 CDD:238011
EGF_CA 3941..3976 CDD:238011
LamG 3979..4142 CDD:238058
EGF 4168..4198 CDD:394967
LamG 4247..4368 CDD:238058
EGF_CA 4431..4465 CDD:238011
Blue background indicates that the domain is not in the aligned region.

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