DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and Pcdh15

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_001258306.2 Gene:Pcdh15 / 690865 RGDID:1590969 Length:1791 Species:Rattus norvegicus


Alignment Length:1681 Identity:420/1681 - (24%)
Similarity:653/1681 - (38%) Gaps:445/1681 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 PPVFQGSLSTVIDEDSPINTLVLTVHARDGDTGEP-RKIVYDLRTNPNDYFLLDAQTGEL---RT 302
            ||    :....|||:|...|:::......|..|.| ..|...|:.|.:.:.|||.....|   .|
  Rat    44 PP----ATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNST 104

  Fly   303 AKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSL 367
            .:.|||   :....|.|:|::. :.||....    |....:..:.:||.||:.|.|.|:.|..::
  Rat   105 GRVLDR---DPPMNIHSIVVQV-QCVNKKVG----TVIYHEVRIVVRDRNDNSPTFKHESYYATV 161

  Fly   368 LENTLPGTPL----ALDMSVSDADVGINSKFALRL-----DDVSG-VFDVEPKLVTGYSQVNIRV 422
            .|.|..||.:    |.|...:|.|.|.|.:....:     |..|. .|:: |.::||    |: |
  Rat   162 NELTPVGTTIFTGFAGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEI-PLMLTG----NV-V 220

  Fly   423 ANGTLDYENPNQRKFIVLVVAEE--TDTNPRLSSTATITVSVLDANDNKPVF------------E 473
            ....|:||  ::.::.|::.|.:  .:.|.|.::|.|:||.|||.:|..|:|            .
  Rat   221 LRKRLNYE--DKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCR 283

  Fly   474 QESYSASVSEAALPGQ---YIAT--ITARDVDSGSYGDS---GIRYS-LSGTGAE---LFHVNEQ 526
            ..:|.|::.|...|.:   .:.|  |.|.|.|......|   ||.|| |.||..:   ..|::.:
  Rat   284 PLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFLHMHPR 348

  Fly   527 TGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAP 591
            |..::|.             ..:|.|.|.:.|                                 
  Rat   349 TAELTLL-------------EPVNRDFHQKFD--------------------------------- 367

  Fly   592 EEQASSVPLPAPVPHAAPSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLR 656
                                                         |..||..|||....:..||.
  Rat   368 ---------------------------------------------LVIKAEQDNGHPLPAFASLH 387

  Fly   657 ISVTDANDSPPVCESPLYRASVDE----GAVVFDS-----PLIVKARDADTMSRISYRIRGSEQV 712
            |.:.|.|:..|....|.|:..:.|    ||.:.:|     ||.:.|.|.|.           |.|
  Rat   388 IEILDENNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDI-----------EDV 441

  Fly   713 -------------------ESIFDIDRETGQIIIRPNATLDVTNLNSDQ-LIFAVEANDGLFTAH 757
                               .|:|.: ..||  |.|....|...:....| ..|.:.|.||:..:.
  Rat   442 PPGGVPTKDPELHLFLNDYTSVFTV-TPTG--ITRYLTLLQPVDREEQQTYTFLITAFDGVQESE 503

  Fly   758 -CGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDDF 821
             ..|||.|.|.|::.|.|.:.||:..|..:...|.||.::.|.|.|.|.|.|:.|.|..||..||
  Rat   504 PVVVNIRVMDANDNTPTFPEISYNVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGSKGDF 568

  Fly   822 GIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAE 886
            .|..|||.|.::..::.....||.|.:||||                                  
  Rat   569 VINRTTGLVSIAPGVELVVGQTYALTVQASD---------------------------------- 599

  Fly   887 VRADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSV 951
               :|||.:                                                        
  Rat   600 ---NAPPAE-------------------------------------------------------- 605

  Fly   952 NKQLDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQI--KLQMV 1014
                .|:....:.|.||     .||               |::||||        ||:  .|::.
  Rat   606 ----RRHSICTVYIEVL-----PPN---------------NQSPPRF--------PQLMYSLEVS 638

  Fly  1015 EEQPVGTVLTTLQANDEDSSIGEFNISDND---YFAINQTSGMIYTIARLDYEVVKEVKFQVTVS 1076
            |...:|.||..|||.|.:.....:.|.:.|   .|.:::|:|::.....||.|........||.|
  Rat   639 EAMRIGAVLLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTAS 703

  Fly  1077 DTGVPALTATADVVVDIINLNDNDPKFSQSDYY----FNVTENSPRGTVAGKVEAHDGDVGVFGE 1137
            | |.|..|:||.|.:.:.::|||.|.|   |.|    .:|.|......| |:|.|.|.|.|:.|:
  Rat   704 D-GRPDGTSTATVNIVVTDVNDNAPVF---DPYLPRNLSVVEEEANAFV-GQVRATDPDAGINGQ 763

  Fly  1138 ITYTLIGENNKYFSIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINIL 1202
            :.|:| |..|..|.|   |.|..:..:..|:||......|.|||.|  .|...:.:|.|::|.:|
  Rat   764 VHYSL-GNFNNLFRI---TSNGSIYTAVKLNREARDHYELVVVATD--GAVHPRHSTLTLYIKVL 822

  Fly  1203 DVNDNAPVFTRDVYNSTVAENAAYQPPA--ALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDA 1265
            |::||:||||...|...|.||.    ||  |.||::|.|.|.|  .:|.|.|.:.....||.|..
  Rat   823 DIDDNSPVFTNSTYTVVVEENL----PAGTAFLQIEAKDVDLG--ANVSYRIRSPEVKHLFALHP 881

  Fly  1266 QSGIVYPAQSLS-----GKHGAYELTISARDTQGSGTMESTTKAIITVLR-VNRHKPEFVIPALS 1324
            .:|.:...:||.     .:..:....:.|.|..  |||......:..::: :|.:.|.|      
  Rat   882 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIY--GTMPPGIATVTVIVKDMNDYPPVF------ 938

  Fly  1325 NATIEIPGDIVQPDYL----LLTVRAMDNDTE--ENGKVSYHLQVNNRNEQQTGEFKIDEVTGEL 1383
              :..|...:|.||.:    :.||.|.|.|..  ...:|.|.:. :.:.......|.::|.:|.:
  Rat   939 --SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD-DVQFPYPASIFDVEEDSGRV 1000

  Fly  1384 RAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDANENRPEFPDASNPYK-VSINENSG 1447
            ..:..||.:....:.:::||.|.|.|...|...:.:.::...| .|.|  ....|: ..::|.:.
  Rat  1001 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVLHPGE-IPRF--TQEEYRPPPVSELAA 1062

  Fly  1448 RDVKIGHIQAASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILAS-- 1510
            |...:|.|.||:   .|:.|.|.::.||||..|.::.:||.||.|..||.|....|.|.:.|.  
  Rat  1063 RGTVVGVISAAA---INQSIVYSIVAGNEDDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSL 1124

  Fly  1511 --IKADLHISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAIT 1573
              :.|:|.:.            ::.|| |||.|.:.|.||:||||:|..|..||:.:|:|..::.
  Rat  1125 EVVLANLRVP------------SKSNT-AKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFTSVL 1176

  Fly  1574 LVNATDADQGKNAKIEFMIVASNLYK----FGATKSTGSIVPSPFAISQDGRISANTIMAEYNQD 1634
            .|.|||.|.|..:.:.:.::...:.:    |.....||.|               .|.|..:|..
  Rat  1177 RVKATDRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLI---------------KTAMLFHNMR 1226

  Fly  1635 R--FELEIVARELEQPQSSASTKVNIWVFDGTQL-VRVILSR-PPEEVYQEQEEIIAELRNATQH 1695
            |  |:.:::|  .:......|.|.::.|....|| ::||:|. ||..|.::.|::...|....|.
  Rat  1227 RSYFKFQVIA--TDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1289

  Fly  1696 -----RIIVDEI--RFHLDSIGRIRMDWCDLYFHAVDPQTQQIAPVDEILKDID-RNYDYLKD-- 1750
                 :::|:.|  |.|.|:........|||..:|:||||.:....:|:.|.:| :..|..||  
  Rat  1290 QIPGAKVVVESIGARRHGDAFSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQ 1354

  Fly  1751 -YY--AGFAIENVVPAYIAIVQ---DEFDLAVAGLVALVIVLFVGVISFIVLCCCL 1800
             ||  .|..:|...|..:..::   :........|:||         :||::.||:
  Rat  1355 PYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL---------AFIIILCCI 1401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637
Cadherin_repeat 136..240 CDD:206637
Cadherin_repeat 248..353 CDD:206637 27/108 (25%)
Cadherin_repeat 362..468 CDD:206637 33/117 (28%)
Cadherin_repeat 476..>533 CDD:206637 19/68 (28%)
CA_like <627..667 CDD:481204 11/39 (28%)
CA 692..772 CDD:214520 23/100 (23%)
Cadherin_repeat 778..873 CDD:206637 30/94 (32%)
Cadherin_repeat 882..994 CDD:206637 10/111 (9%)
Cadherin_repeat 1015..1099 CDD:206637 27/86 (31%)
Cadherin_repeat 1108..1207 CDD:206637 33/102 (32%)
Cadherin_repeat 1215..1314 CDD:206637 28/106 (26%)
Cadherin_repeat 1327..1427 CDD:206637 22/105 (21%)
Cadherin_repeat 1437..1549 CDD:206637 36/116 (31%)
Cadherin_repeat 1557..1662 CDD:206637 24/110 (22%)
Pcdh15NP_001258306.2 ECD 36..145 CDD:408229 28/112 (25%)
Cadherin_repeat 156..245 CDD:206637 24/96 (25%)
CA 310..398 CDD:214520 29/178 (16%)
Cadherin_repeat 404..517 CDD:206637 30/126 (24%)
Cadherin_repeat 525..621 CDD:206637 37/197 (19%)
Cadherin_repeat 633..725 CDD:206637 28/92 (30%)
Cadherin_repeat 734..827 CDD:206637 32/99 (32%)
Cadherin_repeat 835..933 CDD:206637 27/105 (26%)
Cadherin_repeat 942..1039 CDD:206637 22/97 (23%)
Cadherin_repeat 1057..1152 CDD:206637 35/110 (32%)
Cadherin_repeat 1161..1255 CDD:206637 24/110 (22%)
Blue background indicates that the domain is not in the aligned region.

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