DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and Cdhr3

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_001019649.1	Gene:	Cdhr3 / 68764	MGIID:	1916014	Length:	831	Species:	Mus musculus

Alignment Length:	857	Identity:	181/857 - (21%)
Similarity:	330/857 - (38%)	Gaps:	228/857 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   879 VPATQHAEVRADAPPGQLVYTL-----IALDPDVANHNALEFAGTDDITAIDKEGKELPHYD--- 935
            :|||  :.|..:|||..||:..     ::|.|                        .:|.:.
Mouse    25 LPAT--SNVAENAPPATLVHKFSVNLSVSLSP------------------------VIPGFPLVV 63

  Fly   936 ---QFKEYFKISR----------NGKVSVN-----KQLDRNLFAVMRINVLVTDSTAPNVQQGRG 982
               .|.|.|:::|          .||..::     |..|..::  ::.:|.|||     ||
Mouse    64 NPRPFTEAFRVNRLSATNFEVVTTGKEQLDFERGPKAFDLQIY--VKDDVGVTD-----VQ---- 117

  Fly   983 LLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDSS----IGEFNISDN 1043
            :|.:|:.|||: ||:|.   .:....:.|.::|....|.:......:.||:|    :|.|.||.:
Mouse   118 VLTVQVTDVNE-PPQFQ---GILAQGLNLYVIERTNPGFIYQVEAFDPEDTSRSIPLGYFLISPS 178

  Fly  1044 DYFAINQTSGMIYTIARLDYEV-VKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQSD 1107
            ..|.:: .:|.:::...||:|. .|.....|.|.|:|  .|.|:..:.|.|:|:||..|:|:...
Mouse   179 KNFRMS-ANGTLFSTTELDFEAGHKSFNLLVGVRDSG--NLEASTALQVTIVNINDETPRFTSPR 240

  Fly  1108 YYFNVTENSPRGTVAGKVEAHD-GDVGVFGEITYTLIGENNKYFSIDAYTGNVMVANSSILDREQ 1171
            ..::|.|..|.||:...:.|.| .|.|..|.:.|: |...:.||.:|..||.:.||.....|..:
Mouse   241 RVYSVPEEVPLGTMVANITAMDPDDEGFPGRLLYS-ITTTSSYFMVDQLTGTIQVARRLDRDAGE 304

  Fly  1172 IKE---LTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPAALL 1233
            :::   ::|.|..:|: |:..|::......| :.|:|||.....:..::..:.|..|   ...||
Mouse   305 LRQNPIISLEVRVRDR-PSGGQENRMQITFI-VEDINDNPATCRKLTFSIMLPERTA---NGTLL 364

  Fly  1234 QVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSGKHGAYELTISARDTQGSGTM 1298
                :|.::..:.|                |:::           .:..:..|..:    |:|:.
Mouse   365 ----LDLNKFCFDD----------------DSEA-----------PNNKFNFTTPS----GAGSS 394

  Fly  1299 ESTTKAIITVLRVNRHKPEFVIPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQV 1363
            .          |.::|      || .:..|.:.||:   ||             ||..   :|.|
Mouse   395 R----------RFSQH------PA-GSGRIVLTGDL---DY-------------ENPS---NLAV 423

  Fly  1364 NNRNEQQTGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDANENR 1428
            .|                              .|::::..:||..|.::  :.:.:||:...||
Mouse   424 GN------------------------------VYNVMIQVQDAAPPYYK--KSIYISILTRPEN- 455

  Fly  1429 PEFP-DASNP-YKVSINENSGRDVKIGHIQAASRSKHNRDIFYYMLLGNED----GAFYVDKLTG 1487
             ||| ....| |...:.|......:||.::|.........:.|.:..|...    ..|:::..||
Mouse   456 -EFPLIFERPSYVFDVPERRPARTQIGQVRATDADFPRTPVVYSVSRGGSSLQYPNIFWINPKTG 519

  Fly  1488 DIYTNKSLDREETDVYTLYILASIKADLHISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPV 1552
            ::......|.|.|.||.|.:.|:       :.|:|:|.:            |.:.:|..||..||
Mouse   520 ELQLITQADHETTSVYILTVEAT-------NGEDRSSVT------------VTVNILGENDEKPV 565

  Fly  1553 FEKPIYYAGVNANAKMGAAIT--LVNATDADQGKNAKIEFMIVASNLYK-FGATKSTGSIVPSPF 1614
            .....|:..:..:.|:|..|.  .:..||.|...:: ..:.|.:.|:.. |..:.:.||.:....
Mouse   566 CTPNFYFMAIPVDLKVGTNIQNFKLTCTDLDSSPSS-FRYSIGSGNINNHFTFSPNAGSNITRLL 629

  Fly  1615 AISQDGRISANTIMAEYNQDRFELEIVARELEQPQSSASTKVNIWVFDGTQLVRV-ILSRPPEEV 1678
            ..|:....|.:|:        ::.:::....:....|.|||....|..||..:.| ::..|...:
Mouse   630 LASRFDYSSLDTV--------WDYQLLVHITDDNLLSGSTKAKALVETGTVTLSVKVIPHPTTTI 686

  Fly  1679 YQEQEEIIAELR 1690
            ...:..|..::|
Mouse   687 TTPRPRITYQIR 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		E_set	<627..667	CDD:298831
		CA	692..772	CDD:214520
		Cadherin_repeat	778..873	CDD:206637
		Cadherin_repeat	882..994	CDD:206637	29/137 (21%)
		Cadherin_repeat	1015..1099	CDD:206637	25/88 (28%)
		Cadherin_repeat	1108..1207	CDD:206637	28/102 (27%)
		Cadherin_repeat	1215..1314	CDD:206637	11/98 (11%)
		Cadherin_repeat	1327..1427	CDD:206637	16/99 (16%)
		Cadherin_repeat	1437..1549	CDD:206637	24/116 (21%)
		Cadherin_repeat	1557..1662	CDD:206637	20/107 (19%)
Cdhr3	NP_001019649.1	Cadherin_repeat	30..128	CDD:206637	27/132 (20%)
		Cadherin_repeat	141..231	CDD:206637	25/92 (27%)
		Cadherin_repeat	242..341	CDD:206637	28/101 (28%)
		Cadherin_repeat	349..456	CDD:206637	32/214 (15%)
		Cadherin_repeat	465..561	CDD:206637	22/114 (19%)
		Cadherin_repeat	571..679	CDD:206637	23/116 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	743..763
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100