DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and PCDH15

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_001136235.1 Gene:PCDH15 / 65217 HGNCID:14674 Length:1962 Species:Homo sapiens


Alignment Length:1673 Identity:416/1673 - (24%)
Similarity:660/1673 - (39%) Gaps:436/1673 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 PPVFQGSLSTVIDEDSPINTLVLTVHARDGDTGEP-RKIVYDLRTNPNDYFLLDAQTGEL---RT 302
            ||    :....|||:|...|:::......|..|.| ..|...|:.|.:.:.|:|.....|   .|
Human    44 PP----ATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 104

  Fly   303 AKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSL 367
            .:.|||   :....|.|:|::.:.:...|.     |....:..:.:||.||:.|.|.|:.|..::
Human   105 GRVLDR---DPPMNIHSIVVQVQCINKKVG-----TIIYHEVRIVVRDRNDNSPTFKHESYYATV 161

  Fly   368 LENTLPGTPL----ALDMSVSDADVGINSKFALRL----DDVSG--VFDVEPKLVTGYSQVNIRV 422
            .|.|..||.:    :.|...:|.|.|.|.:....:    ||.:.  .|:: |.::||    || |
Human   162 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTG----NI-V 220

  Fly   423 ANGTLDYENPNQRKFIVLVVAEE--TDTNPRLSSTATITVSVLDANDNKPVF------------E 473
            ....|:||  ::.::.|::.|.:  .:.|.|.::|.|:||.|||.:|..|:|            .
Human   221 LRKRLNYE--DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCR 283

  Fly   474 QESYSASVSEAALPGQ---YIAT--ITARDVDSGSYGDS---GIRYS-LSGTGAE---LFHVNEQ 526
            ..:|.|::.|...|.:   .|.|  |.|.|.|......|   ||.|| |.||..:   .||::.:
Human   284 PLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPR 348

  Fly   527 TGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAP 591
            |..:||.             ..:|.|.|.:.|                                 
Human   349 TAELSLL-------------EPVNRDFHQKFD--------------------------------- 367

  Fly   592 EEQASSVPLPAPVPHAAPSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLR 656
                                                         |..||..|||....:...|.
Human   368 ---------------------------------------------LVIKAEQDNGHPLPAFAGLH 387

  Fly   657 ISVTDANDSPPVCESPLYRASVDE----GAVVFD-----SPLIVKARDADTMSRISYRIRGSEQV 712
            |.:.|.|:..|....|.|:..:.|    ||.:.|     |||.:.|.|.|        |..::..
Human   388 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD--------IEDTKDP 444

  Fly   713 E---------SIFDIDRETGQIIIRPNATLDVTNLNSDQ-LIFAVEANDGLFTAH-CGVNITVRD 766
            |         |:|.: .:||  |.|....|...:....| ..|::.|.||:..:. ..|||.|.|
Human   445 ELHLFLNDYTSVFTV-TQTG--ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMD 506

  Fly   767 VNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDDFGIVETTGEVF 831
            .|::.|.|.:.||...|..:...|.||.::.|.|.|.|.|.|:.|.|..|:..||.|.:|||.:.
Human   507 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 571

  Fly   832 VSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQL 896
            ::..::.....||.|.:||:|                                     :|||.: 
Human   572 IAPGVEMIVGRTYALTVQAAD-------------------------------------NAPPAE- 598

  Fly   897 VYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSVNKQLDRNLFA 961
                                                                       .||...
Human   599 -----------------------------------------------------------RRNSIC 604

  Fly   962 VMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQI--KLQMVEEQPVGTVLT 1024
            .:.|.||     .||               |::||||        ||:  .|::.|...||.||.
Human   605 TVYIEVL-----PPN---------------NQSPPRF--------PQLMYSLEISEAMRVGAVLL 641

  Fly  1025 TLQANDEDSSIGEFNISDND---YFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTAT 1086
            .|||.|.:.....:.|.:.|   .|.:::|:|::.....||.|........:|.|| |.|..|:|
Human   642 NLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTST 705

  Fly  1087 ADVVVDIINLNDNDPKFSQSDYY----FNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENN 1147
            |.|.:.:.::|||.|.|   |.|    .:|.|......| |:|:|.|.|.|:.|::.|:| |..|
Human   706 ATVNIVVTDVNDNAPVF---DPYLPRNLSVVEEEANAFV-GQVKATDPDAGINGQVHYSL-GNFN 765

  Fly  1148 KYFSIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVFT 1212
            ..|.|   |.|..:..:..|:||......|.|||.|  .|...:.:|.|:.|.:||::||:||||
Human   766 NLFRI---TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDIDDNSPVFT 825

  Fly  1213 RDVYNSTVAENAAYQPPA--ALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQS 1275
            ...|...|.||.    ||  .:||::|.|.|.|  .:|.|.|.:......|.|...:|.:...:|
Human   826 NSTYTVLVEENL----PAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRS 884

  Fly  1276 LS-----GKHGAYELTISARDTQGSGTMESTTKAIITVLR-VNRHKPEFVIPALSNATIEIPGDI 1334
            |.     .:..:....:.|.|..  |||......:..::: :|.:.|.|        :..|...:
Human   885 LDYEAFPDQEASITFLVEAFDIY--GTMPPGIATVTVIVKDMNDYPPVF--------SKRIYKGM 939

  Fly  1335 VQPDYL----LLTVRAMDNDTE--ENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKN 1393
            |.||.:    :.||.|.|.|..  ...:|.|.:. :.:.......|:::|.:|.:..:..||.:.
Human   940 VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD-DVQFPYPASIFEVEEDSGRVITRVNLNEEP 1003

  Fly  1394 RANYDIILVARDAGNPPFESLRLLSVSIVDANENRPEFPDASNPYK-VSINENSGRDVKIGHIQA 1457
            ...:.:::||.|.|.|...|...:.:.::...| .|.|  ....|: ..::|.:.:...:|.|.|
Human  1004 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRF--TQEEYRPPPVSELATKGTMVGVISA 1065

  Fly  1458 ASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILAS----IKADLHIS 1518
            |:   .|:.|.|.::.|||:..|.::.:||.||.|..||.|....|.|.:.|.    :.|:|.:.
Human  1066 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1127

  Fly  1519 EEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNATDADQG 1583
                        ::.|| |||.|.:.|.|::||||:|..|..||:.:|:|..::..|.|||.|.|
Human  1128 ------------SKSNT-AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1179

  Fly  1584 KNAKIEFMIVASNLYKFGATKSTGSIVPSPFAISQDGRI------SANTIMAEYNQDR--FELEI 1640
                 .:.::|..|           |:| |....::|.:      ...|.|..:|..|  |:.::
Human  1180 -----NYSVMAYRL-----------IIP-PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQV 1227

  Fly  1641 VARELEQPQSSASTKVNIWVFDGTQL-VRVILSR-PPEEVYQEQEEIIAELRNATQH-----RII 1698
            :|  .:......|.|.::.|....|| ::||:|. ||..|.::.|::...|....|.     :::
Human  1228 IA--TDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1290

  Fly  1699 VDEI--RFHLDSIGRIRMDWCDLYFHAVDPQTQQIAPVDEILKDID-RNYDYLKD---YY--AGF 1755
            |:.|  |.|.|:........|||..:|:||||.:....:|:.|.:| :..|..||   ||  .|.
Human  1291 VESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGR 1355

  Fly  1756 AIENVVPAYIAIVQ---DEFDLAVAGLVALVIVLFVGVISFIVLCCCL 1800
            .:|...|..:..::   :........|:||         :||::.||:
Human  1356 ILEIRTPEAVTSIKKRGESLGYTEGALLAL---------AFIIILCCI 1394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637
Cadherin_repeat 136..240 CDD:206637
Cadherin_repeat 248..353 CDD:206637 25/108 (23%)
Cadherin_repeat 362..468 CDD:206637 33/117 (28%)
Cadherin_repeat 476..>533 CDD:206637 22/68 (32%)
CA_like <627..667 CDD:481204 10/39 (26%)
CA 692..772 CDD:214520 23/90 (26%)
Cadherin_repeat 778..873 CDD:206637 27/94 (29%)
Cadherin_repeat 882..994 CDD:206637 11/111 (10%)
Cadherin_repeat 1015..1099 CDD:206637 27/86 (31%)
Cadherin_repeat 1108..1207 CDD:206637 33/102 (32%)
Cadherin_repeat 1215..1314 CDD:206637 26/106 (25%)
Cadherin_repeat 1327..1427 CDD:206637 22/105 (21%)
Cadherin_repeat 1437..1549 CDD:206637 34/116 (29%)
Cadherin_repeat 1557..1662 CDD:206637 26/112 (23%)
PCDH15NP_001136235.1 ECD 36..145 CDD:408229 26/112 (23%)
Cadherin_repeat 156..245 CDD:206637 24/96 (25%)
CA 310..398 CDD:214520 30/178 (17%)
Cadherin_repeat 404..510 CDD:206637 31/116 (27%)
Cadherin_repeat 518..614 CDD:206637 35/197 (18%)
Cadherin_repeat 626..718 CDD:206637 28/92 (30%)
Cadherin_repeat 727..820 CDD:206637 32/99 (32%)
Cadherin_repeat 828..926 CDD:206637 25/105 (24%)
Cadherin_repeat 935..1032 CDD:206637 22/97 (23%)
Cadherin_repeat 1050..1145 CDD:206637 33/110 (30%)
Cadherin_repeat 1154..1248 CDD:206637 26/112 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1431..1451
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1608..1630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1752..1773
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1935..1962
Blue background indicates that the domain is not in the aligned region.

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