DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and PCDHA6

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_061732.1	Gene:	PCDHA6 / 56142	HGNCID:	8672	Length:	950	Species:	Homo sapiens

Alignment Length:	704	Identity:	183/704 - (25%)
Similarity:	306/704 - (43%)	Gaps:	134/704 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 VVSLRISVTDANDSPPVCESPLYRASVDEGAV-VFDSPL------IVKARDADTMSR--ISYRIR 707
            |..:.:.|.|.||:||:       ..|:|..| :::|.|      :..|.|||..|.  ::|::.
Human   116 VFHVDVEVRDINDNPPL-------FPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLS 173

  Fly   708 GSE----QVESIFDIDRETGQIIIRPNATLDVTNLNSDQLIFAVEANDG---LFTAHCGVNITVR 765
            .||    .|:...|.:::.|.::   ..:||.....:..|.  :.|.||   ..|....:.:||.
Human   174 SSEYFGLDVKINSDDNKQIGLLL---KKSLDREEAPAHNLF--LTATDGGKPELTGTVQLLVTVL 233

  Fly   766 DVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSF---------DDF 821
            |||::.|.|||..|...:.||::.||:|.|::|:|.|.|.|..:.|     ||         |.|
Human   234 DVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISY-----SFNSLVAAMVIDHF 293

  Fly   822 GIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAE 886
            .|...|||:.:...|||::.|.|::.|.|:|:|.|.:.|..|:.:.:.:.||..|.....:....
Human   294 SIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP 358

  Fly   887 VRADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPH-----YDQFKEYFKISRN 946
            ||.||..|.::..:...|.|...:..:..:.|             ||     ...||.|:.:
Human   359 VREDAQFGTVIALISVNDLDSGANGQVNCSLT-------------PHVPFKLVSTFKNYYSL--- 407

  Fly   947 GKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKL 1011
               .::..|||...:...:.|...|..:|:: .....|.:::.|:|.|.|.|      .||:..:
Human   408 ---VLDSALDRESVSAYELVVTARDGGSPSL-WATASLSVEVADMNDNAPAF------AQPEYTV 462

  Fly  1012 QMVEEQPVGTVLTTLQANDEDSS-------------IGEFNISDNDYFAINQTSGMIYTIARLDY 1063
            .:.|..|.|..:.|:.|.|.|:.             :||..:|  .|.:::..||.:|.:..||:
Human   463 FVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALS--SYISVHAESGKVYALQPLDH 525

  Fly  1064 EVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFN---VTENSPR----GTV 1121
            |.::.::|||:..|.|||.|.:...:.|.:::.|||.|..........   |:|..||    |.|
Human   526 EELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQV 590

  Fly  1122 AGKVEAHDGDVGVFGEITYTL--IGENNKY-FSIDAYTGNVMVANSSILDREQIKELTLSVVAQD 1183
            ..||.|.|.|.|....::|.|  ...:.:: |.:..|||.  ::.:.:||........|.|:.:|
Human   591 VAKVRAVDADSGYNAWLSYELQPPASSARFPFRVGLYTGE--ISTTRVLDEADSPRHRLLVLVKD 653

  Fly  1184 KAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEGLYGDV 1248
            ....|:  :||||:.::::: :..||      ..|:.|...|..|.|||:.|..
Human   654 HGEPAL--TATATVLVSLVE-SGQAP------KASSRASVGAAGPEAALVDVNV----------- 698

  Fly  1249 RYIITAGNEMGLFKLDAQSGIVYPAQSLSGKHGAYELTISARDTQGSGTMESTT 1302
             |:|.|  ...:..|...:.::|.|           |..||..|:|:.|.:..|
Human   699 -YLIIA--ICAVSSLLVLTLLLYTA-----------LRCSAPPTEGACTADKPT 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		E_set	<627..667	CDD:298831	5/14 (36%)
		CA	692..772	CDD:214520	23/88 (26%)
		Cadherin_repeat	778..873	CDD:206637	33/103 (32%)
		Cadherin_repeat	882..994	CDD:206637	22/116 (19%)
		Cadherin_repeat	1015..1099	CDD:206637	27/96 (28%)
		Cadherin_repeat	1108..1207	CDD:206637	28/108 (26%)
		Cadherin_repeat	1215..1314	CDD:206637	21/88 (24%)
		Cadherin_repeat	1327..1427	CDD:206637
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
PCDHA6	NP_061732.1	Cadherin_2	30..111	CDD:285466
		Cadherin_repeat	137..238	CDD:206637	27/105 (26%)
		Cadherin_repeat	246..346	CDD:206637	34/104 (33%)
		Cadherin_repeat	354..451	CDD:206637	22/116 (19%)
		Cadherin_repeat	459..561	CDD:206637	27/103 (26%)
		Cadherin_repeat	581..670	CDD:206637	26/92 (28%)
		Cadherin_tail	799..942	CDD:292596
		4 X 4 AA repeats of P-X-X-P	799..894
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7553
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950