DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and PCDHA12

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_061726.1	Gene:	PCDHA12 / 56137	HGNCID:	8666	Length:	941	Species:	Homo sapiens

Alignment Length:	642	Identity:	166/642 - (25%)
Similarity:	283/642 - (44%)	Gaps:	93/642 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 VVSLRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVKARDAD--TMSRISYRIRGSEQVES 714
            |..:.:.|.|.||:|||......:..|.|.|.:.....:..|.|||  ..|.::|.:..:|..|.
Human   116 VFHVDVEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFEL 180

  Fly   715 IFDIDRETG---QIIIRPNATLDVT-NLNSDQLIFAVEANDGLFTAHCGVNITVRDVNNHVPNFE 775
            .....::..   ::::|.....:.| .||  .|:..::......|....:.|||.|||::.|.|:
Human   181 KIKTKKDKSILPELVLRKLLDREQTPKLN--LLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFD 243

  Fly   776 QQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQ----GSFDDFGIVETTGEVFVSRKL 836
            :.||..|:.||.:..|.|.:::|:|.|.|.|.|:.|.|:.    .....|.|...|||:.:..:|
Human   244 KPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGEL 308

  Fly   837 DFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLI 901
            ||:..|.|::|:.|.|:|.||:.|.:.:.:.|.:.||..|..:..:....|:.||..|.::..:.
Human   309 DFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALIS 373

  Fly   902 ALDPDVANHNALEFAGTDDITAIDKEGKELPH-----YDQFKEYFKISRNGKVSVNKQLDRNLFA 961
            ..|.|...:..:..:.|             ||     ...:|.|:.:      .::..|||...:
Human   374 VSDRDSGANGQVICSLT-------------PHVPFKLVSTYKNYYSL------VLDSALDRESVS 419

  Fly   962 VMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTL 1026
            ...:.|...|..:|:: .....:.:::.|||.|.|.|      .||:..:.:.|..|.|..:.|:
Human   420 AYELVVTARDGGSPSL-WATARVSVEVADVNDNAPAF------AQPEYTVFVKENNPPGCHIFTV 477

  Fly  1027 QANDEDSS-------------IGEFNISDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDT 1078
            .|.|.|:.             :||..:|  .|.:::..||.:|.:..||:|.::.::|||:..|.
Human   478 SAWDADAQKNALVSYSLVERRVGEHALS--SYVSVHAESGKVYALQPLDHEELELLQFQVSARDA 540

  Fly  1079 GVPALTATADVVVDIINLNDNDPKF---SQSDYYFNVTENSPR----GTVAGKVEAHDGDVGVFG 1136
            |||.|.:...:.|.:::.|||.|..   ........|:|..||    |.|..||.|.|.|.|...
Human   541 GVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNA 605

  Fly  1137 EITYTL----IGENNKYFSIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATI 1197
            .::|.|    :|.:.. |.:..|||.  ::.:.|||........|.|:.:|....|:  ::|||:
Human   606 WLSYELQPAAVGAHIP-FHVGLYTGE--ISTTRILDEADAPRHRLLVLVKDHGEPAL--TSTATV 665

  Fly  1198 HINILDVNDNAPVFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEGLYGDVRYIITA 1254
            .::::: |..||      ..|:.|...|..|.|||:.:..            |:|.|
Human   666 LVSLVE-NGQAP------KTSSRASVGAVDPEAALVDINV------------YLIIA 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		E_set	<627..667	CDD:298831	5/14 (36%)
		CA	692..772	CDD:214520	20/85 (24%)
		Cadherin_repeat	778..873	CDD:206637	33/98 (34%)
		Cadherin_repeat	882..994	CDD:206637	20/116 (17%)
		Cadherin_repeat	1015..1099	CDD:206637	27/96 (28%)
		Cadherin_repeat	1108..1207	CDD:206637	30/106 (28%)
		Cadherin_repeat	1215..1314	CDD:206637	10/40 (25%)
		Cadherin_repeat	1327..1427	CDD:206637
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
PCDHA12	NP_061726.1	Cadherin_2	30..111	CDD:285466
		Cadherin_repeat	137..238	CDD:206637	23/102 (23%)
		Cadherin_repeat	246..346	CDD:206637	34/99 (34%)
		Cadherin_repeat	354..451	CDD:206637	20/116 (17%)
		Cadherin_repeat	459..561	CDD:206637	27/103 (26%)
		Cadherin_repeat	581..670	CDD:206637	27/93 (29%)
		5 X 4 AA repeats of P-X-X-P	734..885
		Cadherin_tail	790..933	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000