DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and PCDHB15

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_061758.1	Gene:	PCDHB15 / 56121	HGNCID:	8686	Length:	787	Species:	Homo sapiens

Alignment Length:	778	Identity:	177/778 - (22%)
Similarity:	289/778 - (37%)	Gaps:	223/778 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 SEQVESIFDIDRETGQIIIRPNATLDVTNLNSDQLIFAVEANDGLFTAHCG-------------- 759
            ||..|....:|.:|||:|:  |..||...|                   ||
Human    68 SEDNEQGLQLDLQTGQLIL--NEKLDREKL-------------------CGPTEPCIMHFQVLLK 111

  Fly   760 -------VNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGS 817
                   ..:.|.|:|:|.|.|.::..:..:.|.|.:||......|.|||.|.|....|.|...|
Human   112 KPLEVFRAELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNS 176

  Fly   818 FDDFGI-VETTG------EVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKD 875
              .|.: ..|.|      |:.:..:||.:.:...:|.:.|.|.|:|..:||..:.|.|.::||..
Human   177 --HFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNA 239

  Fly   876 PYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEY 940
            |.||.|....:|..::|.|.||..:.|.|.|...:..:.::.......|||.
Human   240 PEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKP------------- 291

  Fly   941 FKISR-NGKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGRGL-----LIIQIIDVNKNPPRFN 999
            |::|. :|::.:.|:||....:...:::..:|        |.||     :.::::|||.|.|..:
Human   292 FELSSLSGEIRLIKKLDFETMSSYDLDIEASD--------GGGLSGKCSVSVKVLDVNDNFPELS 348

  Fly  1000 APWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDSSIGE-----FNISDNDYFAINQTSGMIY--- 1056
            .. |:..|      :.|....|.:...:..|.||  ||     .:|.|:..|.:..:....|
Human   349 IS-SLTSP------IPENSPETEVALFRIRDRDS--GENGKMICSIQDDVPFKLKPSVENFYRLV 404

  Fly  1057 TIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTV 1121
            |...||.|...|....:|::|.|.|.|.....:.|.:.::|||.|.|:|:.|...|.||:.....
Human   405 TEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 469

  Fly  1122 AGKVEAHDGDVGVFGEITYTLIGENNKYF------SIDAYTGNVMVANSSILDREQIKELTLSVV 1180
            .|.|.|.|.|.|...::||:|:...:.:.      ||:...|::....|  ||.|.::.....|.
Human   470 IGSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQS--LDYEALQAFEFRVG 532

  Fly  1181 AQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEGLY 1245
            |.|:...|:  |:.|.:.:.:||.|||:|.
Human   533 ATDRGFPAL--SSEALVRVLVLDANDNSPF----------------------------------- 560

  Fly  1246 GDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLR 1310
                                   ::||.|                    :|:...|
Human   561 -----------------------VLYPLQ--------------------NGSAPCT--------- 573

  Fly  1311 VNRHKPEFVIPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFK 1375
                              |:.....:|.||:..|.|:|.|:.:|..:||.|    ....:.|.|.
Human   574 ------------------ELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQL----LKATEPGLFG 616

  Fly  1376 IDEVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDANENRPEFPDASNPY 1438
            :....||:|....|:.::.|.:.::::.:|.|.||..:...|.|.:||.         .|.||
Human   617 VWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVDG---------FSQPY 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		E_set	<627..667	CDD:298831
		CA	692..772	CDD:214520	18/83 (22%)
		Cadherin_repeat	778..873	CDD:206637	28/101 (28%)
		Cadherin_repeat	882..994	CDD:206637	24/117 (21%)
		Cadherin_repeat	1015..1099	CDD:206637	23/91 (25%)
		Cadherin_repeat	1108..1207	CDD:206637	29/104 (28%)
		Cadherin_repeat	1215..1314	CDD:206637	5/98 (5%)
		Cadherin_repeat	1327..1427	CDD:206637	27/99 (27%)
		Cadherin_repeat	1437..1549	CDD:206637	2/2 (100%)
		Cadherin_repeat	1557..1662	CDD:206637
PCDHB15	NP_061758.1	Cadherin_2	30..112	CDD:285466	14/64 (22%)
		Cadherin_repeat	137..238	CDD:206637	29/102 (28%)
		Cadherin_repeat	247..343	CDD:206637	24/116 (21%)
		Cadherin_repeat	356..447	CDD:206637	23/92 (25%)
		Cadherin_repeat	455..557	CDD:206637	29/105 (28%)
		Cadherin_repeat	576..664	CDD:206637	24/91 (26%)
		Cadherin_C_2	685..768	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000