DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and Pcdh7

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:XP_006504082.1 Gene:Pcdh7 / 54216 MGIID:1860487 Length:1275 Species:Mus musculus


Alignment Length:1422 Identity:321/1422 - (22%)
Similarity:492/1422 - (34%) Gaps:466/1422 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   460 VSVLDANDNKPVFEQESYSASVSEAALPGQYIATITARDVDSGSYGDSGIRYSLSGTGAELFHVN 524
            |.|||.|||.|.|.....:.:|.|....|......||.|.|   :|.:||               
Mouse   131 VIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRD---FGRNGI--------------- 177

  Fly   525 EQTGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQ 589
                                ||.:|.::.......|||           |.:|            
Mouse   178 --------------------ERYELLQEPGGGGGSGEG-----------RRLG------------ 199

  Fly   590 APEEQASSVPLPAPVPHAAPSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVS 654
                .|.|.|.|....::|..|....:.....||:             ....|..:||  :||..
Mouse   200 ----PADSAPYPGGGGNSASGGGSGGSKRRLDAPE-------------GGGGTSPSGR--SSVFE 245

  Fly   655 LRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVKARDADTMSRISY----RIR-GSEQVES 714
            |:::.|...:..|                    .||||.. .|...|.||    |:| |.:...|
Mouse   246 LQVADTPDGEKQP--------------------QLIVKGA-LDREQRDSYELTLRVRDGGDPPRS 289

  Fly   715 IFDIDRETGQIIIRPNATLDVTNLNSDQLIFAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSY 779
                    .|.|:|                                 :.:.|||::.|.||:..|
Mouse   290 --------SQAILR---------------------------------VLITDVNDNSPRFEKSVY 313

  Fly   780 SAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDDFG-----------IVETTGEVFVS 833
            .|.:.|||..||.:.::.|||||.|.|.::.|        .||           :.||:|.:.|.
Mouse   314 EADLAENSAPGTPILQLRATDLDVGVNGQIEY--------VFGAATESVRRLLRLDETSGWLSVL 370

  Fly   834 RKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVR---------- 888
            .::|.:..|..:..:.|.|:|.|..|..||:.:|:::.||..|       ..|:|          
Mouse   371 HRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVP-------SIEIRKIGRIPLKDG 428

  Fly   889 -ADAPPGQLVYTLIAL----DPDVANHNALEFAGTDDI-----TAIDKEGKELPHYDQFKEYFKI 943
             |:.....||.|.|||    |.|...:..:......|:     .|.|.||.:     ..|:||  
Mouse   429 VANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ-----NKKKYF-- 486

  Fly   944 SRNGKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQ 1008
                 :..:..||........:.::..||.:|::..... |::::.|.|.|||.|.      |..
Mouse   487 -----LHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNS-LVVKVGDTNDNPPVFG------QSV 539

  Fly  1009 IKLQMVEEQPVGTVLTTLQANDEDSSIG-----EFNISDNDYFAINQTSGMIYTIARLDYEVVKE 1068
            :::...|....|..:.|:.|.|.||...     ..:.|....|||:..||.|.....||.|....
Mouse   540 VEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGTFAIDPDSGDILVNTVLDREQTDR 604

  Fly  1069 VKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVG 1133
            .:|:|...|.|:|.|..:..|:|.:.:.|||||||.|..:.|.|.||....:..|.|...|.|.|
Mouse   605 YEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKG 669

  Fly  1134 VFGEITYTLIGENNKYFSIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIH 1198
            ...|:: ..|.||:..|||:..||.:....|  .|||.....|..|.|.|....  .:|||||:.
Mouse   670 RNAEMS-LYIEENSNIFSIENDTGTIYSTMS--FDREHQTTYTFRVKAVDGGDP--PRSATATVS 729

  Fly  1199 INILDVNDNAPVFTRDVYNSTVAENAAYQ--PPAA-----LLQVQAIDQDEGLYGDVRYIITAGN 1256
            :.::|.|||||..       |:..|.:|.  ||::     :..|.|.|.|:|:..|:.|.|..||
Mouse   730 LFVMDENDNAPTV-------TLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGN 787

  Fly  1257 EMGLFKLDAQSGIVYPAQSLSGKH-GAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVI 1320
            ...||::|:.||:|.....|:.|| |.:.|.:...|   ||....:|..::.|         ||.
Mouse   788 PFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVND---SGQPSQSTTTLVHV---------FVN 840

  Fly  1321 PALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGK------------------------VSYHL 1361
            .::||||: |...||:..:..||.....:.:.|..|                        ::.:.
Mouse   841 ESVSNATV-IDSQIVRSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVMMARYC 904

  Fly  1362 QVNNRNEQQTGEFKIDE-VTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDAN 1425
            :..|:|..:.|:...:: .|.:...|::..:|::.|.              :|.:.|..|||...
Mouse   905 RSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNK--------------KSKQPLYSSIVTVE 955

  Fly  1426 ENRPEFPDASNPYKVSINENSGRDVKIGHIQAASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIY 1490
            .::|.    ...|. |:||.......:|..::.:....:.|                        
Mouse   956 ASKPN----GQRYD-SVNEKLSDSPSMGRYRSVNGGPGSPD------------------------ 991

  Fly  1491 TNKSLDREETDVYTLYILASIKADLHISEEERASFSIKTLN---RDNTVAKVAITVLDVNDNPPV 1552
                                      ::...::|..:.|:.   :..|..|....|.|:   || 
Mouse   992 --------------------------LARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDL---PP- 1026

  Fly  1553 FEKPIYYAGVNANAKMGAAITLVNATDADQGKNAKI------EFMIVASNLYK-----FGATKST 1606
                       ||..:||            |.|..|      |:....||.|.     ...|...
Mouse  1027 -----------ANTFVGA------------GDNISIGSDHCSEYSCQTSNKYSKQVDTVQTTNPP 1068

  Fly  1607 GSIVPS----PF------AISQDGRISANTIMAEYNQDRFELEIVARELEQPQSSASTKVNIWVF 1661
            |.|..|    ||      .:||.......::.:.|:..   ||    |.|.|.|.:|:       
Mouse  1069 GHIEESCKINPFRRVTFSVVSQPQDPHQGSLQSCYDSG---LE----ESETPSSKSSS------- 1119

  Fly  1662 DGTQLVRVILSRPPEEVYQE--QEEIIAELRNATQHRIIVDEIRFHLDSIGRIRMD--------- 1715
             |.:|..:.|   ||:.|:.  .:..:.|..              |:::..|...|         
Mouse  1120 -GPRLGALPL---PEDNYERTTPDGSVGEAE--------------HMENDSRPLPDVALTGKCTR 1166

  Fly  1716 WCDLYFHA---------------VDPQTQQIAPVDE-------------ILKDIDRN 1744
            .||.|.|:               ..|:.....||||             |:.|.:||
Mouse  1167 ECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRN 1223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637
Cadherin_repeat 136..240 CDD:206637
Cadherin_repeat 248..353 CDD:206637
Cadherin_repeat 362..468 CDD:206637 5/7 (71%)
Cadherin_repeat 476..>533 CDD:206637 10/56 (18%)
CA_like <627..667 CDD:481204 7/39 (18%)
CA 692..772 CDD:214520 15/84 (18%)
Cadherin_repeat 778..873 CDD:206637 31/105 (30%)
Cadherin_repeat 882..994 CDD:206637 27/131 (21%)
Cadherin_repeat 1015..1099 CDD:206637 26/88 (30%)
Cadherin_repeat 1108..1207 CDD:206637 33/98 (34%)
Cadherin_repeat 1215..1314 CDD:206637 31/106 (29%)
Cadherin_repeat 1327..1427 CDD:206637 20/124 (16%)
Cadherin_repeat 1437..1549 CDD:206637 12/114 (11%)
Cadherin_repeat 1557..1662 CDD:206637 27/125 (22%)
Pcdh7XP_006504082.1 Cadherin_repeat 35..139 CDD:206637 5/7 (71%)
Cadherin_repeat 147..304 CDD:206637 52/298 (17%)
Cadherin_repeat 312..411 CDD:206637 32/106 (30%)
Cadherin_repeat 429..531 CDD:206637 25/114 (22%)
Cadherin_repeat 541..635 CDD:206637 26/93 (28%)
Cadherin_repeat 643..738 CDD:206637 33/99 (33%)
Cadherin_repeat 749..839 CDD:206637 29/101 (29%)
Protocadherin 842..1053 CDD:462451 46/307 (15%)
Blue background indicates that the domain is not in the aligned region.

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