DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and pcdh15b

DIOPT Version :9

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:XP_009304712.1 Gene:pcdh15b / 503521 ZFINID:ZDB-GENE-050214-1 Length:1964 Species:Danio rerio


Alignment Length:1768 Identity:420/1768 - (23%)
Similarity:664/1768 - (37%) Gaps:477/1768 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 PPVFQGSLSTVIDEDSPINTLVLTVHARDGDTGEP-RKIVYDLRTNPNDYF-LLDAQTGEL---R 301
            ||    :....|||.||..||::.....:|...:| |.|...||.| |||: :||.....|   .
Zfish    46 PP----ATIVAIDEQSPNGTLLVENMQINGRAEDPDRTISLSLRDN-NDYWVILDPVKQRLYLNS 105

  Fly   302 TAKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVS 366
            |.:.|||:.......|:..|....|||.        |....:..:.:||.||:.|.|....|.|:
Zfish   106 TGRVLDRDPPSYIQSIVVQVQCTNELVG--------TVILHEVRIVVRDRNDNAPRFQQPRYYVA 162

  Fly   367 LLENTLPGTPLALDMS----VSDADVGINSKFALRLD------DVSGVFDVEPKLVTGYSQVNIR 421
            :.|.|..||.:....:    ..|.|.|.|.:....:.      ..:..||: |..::|...:..|
Zfish   163 VNELTPVGTTIFSGFTGNNGAVDIDDGPNGQIEYTIQYNPRDPTTNRTFDI-PLTLSGSVVLRER 226

  Fly   422 VANGTLDYENPNQRKFIVLVVAEETDTNP--RLSSTATITVSVLDANDNKPVF------------ 472
                 |:||...  :::|::.|.:...||  ||::|.|:||.|||.:|..|:|            
Zfish   227 -----LNYEEIT--RYLVIIQANDRAPNPKDRLTATTTLTVDVLDGDDLGPMFLPCSLVDNTRDC 284

  Fly   473 EQESYSASVSEAALPGQ-----YIATITARDVDSGSYGDS---GIRYSL----SGTGAELFHVNE 525
            :..:|.||:.|...|.:     ....|.|.|.|......|   ||.||:    ..|..|.|.:|.
Zfish   285 KPLTYRASILELTDPSRVNPVNVTPPIQAVDQDRNIQPPSDRPGILYSILIGKPETYGEFFWMNR 349

  Fly   526 QTGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQA 590
            .|..:.|                                    ::|.:||               
Zfish   350 STAELQL------------------------------------LKAISRE--------------- 363

  Fly   591 PEEQASSVPLPAPVPHAAPSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSL 655
                                                 .|:.   :.|..||..|||....:..:|
Zfish   364 -------------------------------------KYQH---FDLVIKAEQDNGHPLPAFANL 388

  Fly   656 RISVTDANDSPPVCESPLYRASVDEGAVV---------FDSPLIVKARD------ADTMSRISYR 705
            .|.|.|.|:..|..:...|...:.|.|.:         ..:||.:...|      .|.|.|||. 
Zfish   389 HIEVLDENNQAPYFQVATYHGFISESAPLGTTISSSANLSTPLAIIVLDNDIEETKDPMVRISL- 452

  Fly   706 IRGSEQVESIFDIDRETGQII-----IRPNATLDVTNLNSDQLIFAVEANDGL-FTAHCGVNITV 764
                :....||.:  ..|.|:     :||     |.:.......|.:.|:||: .:|...:||||
Zfish   453 ----DNYNGIFAV--TAGGIVRYLTLLRP-----VDHEEQPTYAFTMIASDGVQESAPVTINITV 506

  Fly   765 RDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDDFGIVETTGE 829
            .|.|::.|.|...||...|..:.:.|..|.::.|.|.|.|.|..:.|:|..|....|.|.:.||.
Zfish   507 IDANDNTPTFPNVSYGVSVYTDMQPGDPVLQLTALDADDGPNGLVSYKILAGDQGHFTINDCTGV 571

  Fly   830 VFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPG 894
            :.|...::.....:|.|.::|:|.| |:....:::|                |.:.||       
Zfish   572 ITVLPSVNLTVGRSYALTVRATDNG-PTAQRRSSIT----------------TVYIEV------- 612

  Fly   895 QLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSVNKQLDRNL 959
                                                ||                           
Zfish   613 ------------------------------------LP--------------------------- 614

  Fly   960 FAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLT 1024
                           ||               |::||||:      |....|::.|....|..|.
Zfish   615 ---------------PN---------------NQSPPRFH------QLVYSLEISEAMRTGATLL 643

  Fly  1025 TLQANDEDSSIGEFNI---SDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTAT 1086
            .:||.|.:.....::|   ..|:.|.::||||::.....||.|:.......||.|| |.|..|:|
Zfish   644 NIQATDREKDPITYSIQKGDPNNVFEVSQTSGLLLLAKTLDREITDHYTLTVTASD-GKPDGTST 707

  Fly  1087 ADVVVDIINLNDNDPKFSQSDYYFNVT-ENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYF 1150
            ..|.:.:.::|||||:|... ...|:| :........|:|:|.|.|:|:.|::.|.|:    .|.
Zfish   708 TTVNIAVTDVNDNDPEFDPL-LPLNLTVQEEEANAFVGQVKATDLDLGINGQVRYRLV----SYP 767

  Fly  1151 SIDAYTGNVMVANSSILDREQIKELTLSVVAQD--KAPAAVQKSATATIHINILDVNDNAPVFTR 1213
            .:...:.|..:..:..||||:..:..|.|.|.|  |.|    :..|.|:.|.:|||:||:|||:.
Zfish   768 DLFRISPNGSIFTAMPLDREERAQYDLIVQASDGAKDP----RRTTITLSITVLDVDDNSPVFSP 828

  Fly  1214 DVYNSTVAENAAYQPPAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSG 1278
            ..|::|:.||:..  ...:|.:.|:|.|  |..:|.|.|.......||.:::.:|.:...:||. 
Zfish   829 PAYHATLPENSPV--GTVILNISALDPD--LDANVTYRIRTKEARELFAVNSLTGELKVLRSLD- 888

  Fly  1279 KHGAYELTISARDTQ---------GSGTMESTTKAI-ITVLRVNRHKPEF--------VIPALSN 1325
                :|..:....||         |||.|.....:: :|||.:|...|.|        |.|   |
Zfish   889 ----FEKLLPNATTQTFVVEALDGGSGKMPPGLASVTVTVLDMNDFPPVFSQTLYRGMVAP---N 946

  Fly  1326 ATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVN-NRNEQQTGEFKIDEVTGELRAKTQL 1389
            |   :.|.||      ..|.|.|.|.........|.:.: .:....|..|.::|.:|.:..:..|
Zfish   947 A---VKGTIV------TAVHAEDLDPPGTAASRVHYKADLEQFPYSTSIFDVEENSGNIFTRVNL 1002

  Fly  1390 NRKNRANYDIILVARDAGNP-----PFESLRLLSVSIVDANENRPEFPDASNPYKVS-INENSGR 1448
            |.:....:.:.::|.|.|.|     ....:.:|.:||:      |.|  ....|:.: ::||:..
Zfish  1003 NEEPNTKFSLAVIAYDDGEPMKFNKSLVEITVLQLSII------PVF--TQEEYRFAPVSENAPV 1059

  Fly  1449 DVKIGHIQAASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKA 1513
            ....|.|.||:   .|:.|.|.::.|||.|.|.|:..||.|.|.|.||.|....|.|    .::|
Zfish  1060 GTVAGVILAAA---INQTIVYSIIEGNEGGEFVVNNNTGVISTAKPLDYESNSSYVL----RVEA 1117

  Fly  1514 DLHISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNAT 1578
            |    .....|.:::...:.|| |||.|.|.|.||:||||.||.|..||..:||...::..|.|.
Zfish  1118 D----SMRVVSSNLRAPAKSNT-AKVFIDVQDENDHPPVFTKPFYLGGVAEDAKTFTSVLQVQAL 1177

  Fly  1579 DADQGKNAKIEFMIVASNLYKFGATKSTGSIVPSPFAISQDGRISANTIMAEYNQDRFELEIVAR 1643
            |.|.|..:.:.:.::..     ..|......|..||.    |.|....:.....:..|:.::||.
Zfish  1178 DKDTGNYSAMLYRLIIP-----PTTDGKDGFVIEPFT----GVIKTAIMYRNMRRSYFKFDVVAT 1233

  Fly  1644 ELEQPQSSASTKVNIWVFDGTQLVRVILSRPPEEVYQEQEEIIAELRNATQHRIIVDEI---RFH 1705
            :......|:|.:|.:.|.:...:..|:.:.||..|.|.::.:|..|     .|.:.|:|   :..
Zfish  1234 DNYGEGLSSSAQVVVSVVNQLDMQVVVSNVPPTVVEQNKDRLIGIL-----ERYVQDQIPGAKVV 1293

  Fly  1706 LDSIGRIRM-------DW--CDLYFHAVDPQTQQIAPVDEILKDID-RNYDYLKDY--YAG---- 1754
            ::|||..|.       |:  .||..:|:||.|.:.....|:.|.:| :..|..|::  |.|    
Zfish  1294 MESIGARRFGDGYEQEDYTKSDLMVYAIDPLTNRALSRQELFKFLDGKLLDINKEFQPYLGRGGR 1358

  Fly  1755 -------FAIENVVPAYIAIVQDEFDLAVAGLVALVIVLFVGVISFIVLCC-------------- 1798
                   ..:|:|..|..::...|     ..|:||.::        |:|||              
Zfish  1359 ILEIRTPDVVESVTRAVHSVGYTE-----GALLALAVI--------IILCCIPAILIVIITYRQF 1410

  Fly  1799 ------CLKHWNLSVPVETRRKEALIKKQIIEDLNTTENPLWIEQKLKLY---EEQELTMQVFSE 1854
                  |.|...:.:.:.|.:........:.|:|.        :..::.|   |:|:|.......
Zfish  1411 KERQAECAKTARIQMALPTGKSGGAATNNLYEELG--------DSTMRGYGHQEQQQLLRPSLLR 1467

  Fly  1855 PDHISNSEA--PG 1865
            |:.:|....  ||
Zfish  1468 PEELSMESGIDPG 1480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637
Cadherin_repeat 136..240 CDD:206637
Cadherin_repeat 248..353 CDD:206637 32/109 (29%)
Cadherin_repeat 362..468 CDD:206637 31/117 (26%)
Cadherin_repeat 476..>533 CDD:206637 19/68 (28%)
E_set <627..667 CDD:298831 12/39 (31%)
CA 692..772 CDD:214520 24/91 (26%)
Cadherin_repeat 778..873 CDD:206637 25/94 (27%)
Cadherin_repeat 882..994 CDD:206637 8/111 (7%)
Cadherin_repeat 1015..1099 CDD:206637 26/86 (30%)
Cadherin_repeat 1108..1207 CDD:206637 29/101 (29%)
Cadherin_repeat 1215..1314 CDD:206637 28/108 (26%)
Cadherin_repeat 1327..1427 CDD:206637 21/105 (20%)
Cadherin_repeat 1437..1549 CDD:206637 38/112 (34%)
Cadherin_repeat 1557..1662 CDD:206637 23/104 (22%)
pcdh15bXP_009304712.1 Cadherin_repeat 159..267 CDD:206637 31/115 (27%)
Cadherin_repeat 288..396 CDD:206637 34/198 (17%)
Cadherin_repeat 406..512 CDD:206637 29/117 (25%)
Cadherin_repeat 520..616 CDD:206637 30/197 (15%)
Cadherin_repeat 627..720 CDD:206637 27/93 (29%)
Cadherin_repeat 729..822 CDD:206637 29/100 (29%)
Cadherin_repeat 831..929 CDD:206637 27/106 (25%)
Cadherin_repeat 939..1035 CDD:206637 22/107 (21%)
Cadherin_repeat 1047..1148 CDD:206637 38/112 (34%)
Cadherin_repeat 1161..1240 CDD:206637 17/87 (20%)
NESP55 <1784..1894 CDD:115071
SRRM_C 1846..>1893 CDD:291883
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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