Protein Alignment Cad87A and Cad88C

DIOPT Version :10

• Sequence 1: NP_731649.2
• Gene: Cad87A / 41441
• FlyBaseID: FBgn0037963
• Length: 1975
• Species: Drosophila melanogaster
• Sequence 2: NP_731930.3
• Gene: Cad88C / 41774
• FlyBaseID: FBgn0038247
• Length: 1981
• Species: Drosophila melanogaster
• Alignment Length: 2105
• Identity: 567/2105 - (26%)
• Similarity: 886/2105 - (42%)
• Gaps: 400/2105 - (19%)

  Fly     5 LGLLMICLGLTLAKGETNLPPVFT-QTLNNIIL----YENVTVGTVVFRLEAYDPEGSPVTYG-- 62
            :.:.:|.|...::...:|.||.|. ...:.|:|    .....|||:::.|:.|||:..|:|:|
  Fly    39 ISIQVIILTTLISLVASNRPPRFAIDGQSEIVLRLKESPETKVGTLIYTLKGYDPDNDPLTFGKR 103

  Fly    63 -AIGADHFSVDPVSGN---ITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIIL 123
             :..::...::...||   |.|.|.||||.:|....::::.|     ......|.|......::.
  Fly   104 NSHDSEIIRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTD-----SHYSDHNYVTQSFLLLVE 163

  Fly   124 DLNDNPPEFQNTPYE--ADVNEDAAVGTTIFDKITVKDRDIVGESLDLKCLPQQQSPEACRKFRL 186
            |:|||.|.|  .||:  .::.|.:|.|.....:.|..|....|:.:                :.|
  Fly   164 DINDNVPTF--LPYQNAIEIPEGSAPGVVSTLEATDADEGAYGQVV----------------YYL 210

  Fly   187 HIIKRDATILEAA-------VVLNDTLNYNQRMVYHFQIEATD----GPHKTQT-TFEARVKDVQ 239
            ..:..|..:...|       :.|...|:|.::.:|..::.|.|    ||..|.| ....:|||::
  Fly   211 QELDGDNDVFSIATHQGKGILRLQKELDYERKSLYQLRVLAIDRANQGPINTGTAAILVKVKDLE 275

  Fly   240 DKPPVF-QGSLSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDLRTNPNDYFLLDAQTGELRTA 303
            |:||.| :......|.||:|:.|.||.|.|.|||.|....|.|.|..  ||.|.::..||.:.|.
  Fly   276 DQPPEFVEVQAVARIAEDAPVGTKVLRVRAIDGDRGINNPIAYSLEA--NDLFDINPHTGIVHTL 338

  Fly   304 KPLDREALEDS-TGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSL 367
            ..||||...|. .|...|.|.|.||........|.|..| :.||.:.||||..|.|....|...:
  Fly   339 TKLDREEQSDQVNGAHILRISATELSKSNTQMAPTTVRT-EVTVIVSDVNDEIPTFGETVYRCEV 402

  Fly   368 LENTLPGTPL-ALDMSVS----DADVGINSKFALRLDDVSGVFDVEPKLVTGYSQVNIRVANG-T 426
            .||....||| .:|..|.    |.|.|.|..|.|.||..:.:|::.|:|....:...:||.|. :
  Fly   403 NENAQTNTPLNFIDEEVQNVVFDHDEGNNGTFRLFLDPPNDLFEIVPELAVNEANFMLRVKNSKS 467

  Fly   427 LDYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAALPGQYI 491
            ||:|...:..|.:.  |.|.|...|.|| |.:.:.:.|.|||.|.|.|..|:|||.|.:.....|
  Fly   468 LDFEQFTEVNFTIF--AREVDEPSRWSS-AHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTII 529

  Fly   492 ATITARDVDSGSYGDSGIRY-SLSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLNEDEHV 555
            ..:.|.|||||.||..|||| :|.|..|.|.::|..||||::
  Fly   530 THVQAVDVDSGDYGTMGIRYTNLRGGIAHLLNLNPITGVITI----------------------- 571

  Fly   556 EEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPSGVPAATANDD 620
                                                 :||..
  Fly   572 -------------------------------------KQAGG----------------------- 576

  Fly   621 KAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDEGAVVF 685
                |..|.|..:.::|:.:|.|:.|:|:.:...:.:.:.|.||:.|......|...:.|....|
  Fly   577 ----TAFDREIISRHYLTVEAIDNAGQGNRNTAQIIVDILDVNDNAPTFPQRQYETKLLENQAEF 637

  Fly   686 DSPLIVKARDAD----TMSRISYRIRGSEQVESI----FDIDRETGQIIIRPNATLDVTNL---- 738
            ::||.::|||||    ..|:::|.|     ||.:    |.||.::|  ::||..:.|...|
  Fly   638 ETPLQLEARDADLNGTENSQVTYEI-----VEGLYRSNFTIDPQSG--LLRPVHSFDFEELVDGS 695

  Fly   739 ---------------NSDQLIFAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSE 788
                           ..|.|:.|.::...:.:....|.|.|:|||::.|.|:|..|:..|.|:..
  Fly   696 SRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPEDLP 760

  Fly   789 IGTSVERVHATDLD-TGKNAELRYRIQQGSFDDFGIVETTGEVFVSRKLDFD------RRNTYQL 846
            .|:||.:|.|.|.| :..|..:.||||.|:.|.|.|...||.:.|:...:.|      :|:.|.|
  Fly   761 GGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGDKFIINSETGVISVAHGANLDPDLTESKRSLYTL 825

  Fly   847 QIQASD--QGTPSLTGTATLTINVQNSNDKDPYF--VPATQHAEVRADAPPGQLVYTLIALDPDV 907
            .:.|.|  .|...|..|.|:.|::|:.|:|.|..  :||.|..|   :.|.|.|||.:.|.|.|
  Fly   826 SVIALDGGLGNSQLMTTCTVNISIQDVNNKPPVLKEMPALQILE---NTPVGTLVYRIQATDLD- 886

  Fly   908 ANHNAL--------EFAGTDDITAIDKEGKELPHYDQFKEYFKI-SRNGKVSVNKQLDRNLFAVM 963
              |.|:        ...|..:..|:.|..:    || |...|:: |..|.:.|.|.|||.....:
  Fly   887 --HKAILRYKLNPEHCEGRTEEGALVKSSE----YD-FLGAFEVDSIEGTLKVVKLLDRERVEHI 944

  Fly   964 RINVLVTDSTAPNVQQ-GRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQ 1027
            ::.:.|.|..|...:| ..|.|.||::|.|.|.|:|..|:      .:..:.|....|.::..:.
  Fly   945 KLAITVEDLAAAKGRQIAEGFLSIQVLDENDNNPKFRLPF------YRQSITENSINGAMIVNVL 1003

  Fly  1028 ANDEDSS-----IGEFNISDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATA 1087
            |:|.|.:     ..|.|.:......::..:|.|...:::|:|..:.:.|.|..:|:|:||.::..
  Fly  1004 ASDVDKNRTITYALEGNPTYRSLMHLDPQTGEIVVASKIDHEQHQWLNFSVRATDSGIPARSSLV 1068

  Fly  1088 DVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTL--IGENNKYF 1150
            ||.:.:::.|||:|.|......:.::||:..||....::|.|.|.|.||:||:.:  |....| |
  Fly  1069 DVYITVLDENDNNPYFVGGSKNYTISENAAPGTRVATLQAGDADSGDFGKITFLMDRISSQGK-F 1132

  Fly  1151 SIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAP----AAVQKSATATIHINILDVNDNAPVF 1211
            :|||.||.:.||:.  ||||......|.:.|.|...    |...::|...:.|:|||.|||.|..
  Fly  1133 TIDADTGVLTVADR--LDRESKDSYNLVIEAWDNYQFGFLAGESRNAFKQVFISILDENDNPPEV 1195

  Fly  1212 TRDVYNSTVAENAAYQPPAALLQVQAIDQDEGL--YGDVRYIITAGNEMGLFKL---DAQSGIVY 1271
              |:..|.|.....::....:..:...|.|:..  .|.:.:.||.||:.|:|:|   ||.:..::
  Fly  1196 --DLPMSCVLITEYHELHERVASIVGKDADDPTTPNGRLDFAITRGNKDGMFELRQIDAWNAQIF 1258

  Fly  1272 PAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIEIPGDIVQ 1336
            .::||..::|.|.|||:.||......:...| ..|.|...|.|.|.||.| |.|.|:.|| :...
  Fly  1259 ASKSLRNRYGNYSLTITTRDMGLPANIVHNT-LDICVSDFNDHAPVFVRP-LHNTTVRIP-ENAT 1320

  Fly  1337 PDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNRANYDIIL 1401
            ...|:|...|.|.|..:|..|.|.|:.:.....:.  |::|..||||..|.||||:.:..::|.:
  Fly  1321 VGTLILQAYASDGDMGQNALVRYRLKPDPLGSYKM--FEVDGSTGELFLKEQLNREKQKIHEIRI 1383

  Fly  1402 VARDAGNPPFESLRL-LSVSIVDANENRPEFPDASNPYKVSINENS---GRDVKI------GHIQ 1456
            .|.|.|.|...|..| |::.:.:.|:..|:|  ..|...|:..|:|   ...:|:      ..::
  Fly  1384 EAYDQGLPTSLSSDLDLTIYVRNVNDYEPQF--MVNEISVNFTEHSDPGSERIKLPDTIDKDQLE 1446

  Fly  1457 AASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILA--SIKADLHISE 1519
            ....:.....:.|:::.|||.|.|.:|..|..:..::.||||....:|||:.|  :.:.|.....
  Fly  1447 LDDPNDTPSQVCYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTLYVRATENCRNDSISGG 1511

  Fly  1520 EERASFSIKTLNR---------------------------------------------------- 1532
            |:|....|:..||
  Fly  1512 EKRRRMGIEINNRLGGIVHNQQFGYDRFKHSRQLRSTESNEYGPEDAELLSYEAYDSSQEDPTGG 1576

  Fly  1533 --------DNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNATDADQGKNAKIE 1589
                    |:||.||.:.|||:|||||.|...|:..|:..||..|.....|.|||||:|.|.:|.
  Fly  1577 LATTHPELDSTVIKVKVRVLDINDNPPRFRSKIFTGGITTNADFGLKFMRVEATDADEGDNGRIG 1641

  Fly  1590 FMIVASNLYKFGATKSTGS-----IVPSPFAISQD-GRISANTIMAEYNQDRFELEIVARELEQP 1648
            :       |:.|..:.|.|     :..:||.:.|: |.:..|....:..:..|:..::|.:....
  Fly  1642 Y-------YQVGEIRQTLSEGLENVRKAPFLLDQETGEVQLNFDPQKGMKGYFDFVVLANDTSGM 1699

  Fly  1649 QSSASTKVNIWVFDGTQLVRVILSRPPEEVYQEQEEIIAELRNATQHRIIVDEIRFHLDSIGRIR 1713
            :..|  .|.|::....|.||.:....|:|:....:.....|.|.|:..:.:|||:.|.:..|.:.
  Fly  1700 KDVA--HVFIYLLREDQKVRFVFRLQPDELRSRVDSFRDTLSNITESIVNIDEIKVHENKDGSVD 1762

  Fly  1714 MDWCDLYFHAVDPQTQQIAPVDEILKDIDRNYDYLKDYYAGFAIENVVPAYIAIVQDEFDLAVAG 1778
            ....|||.|.|:.:...|..|.|:||.||.:.:.|...:...   ||:....|    |..|..||
  Fly  1763 KTKTDLYMHLVEREDNSIYEVSEVLKLIDSHIESLNGLFKEL---NVLDTQAA----EAQLLTAG 1820

  Fly  1779 ------LVALVIV-LFVGVISFIVLCCCLKHWNLSVPVETRRKEALIKKQI--------IEDL-- 1826
                  .|.|:.. ||:..:..:.:..|....|     ..||:....|..|        ::|.
  Fly  1821 PSRGPLFVWLIFTNLFLATLLVVTIALCASQRN-----GYRRQLRAAKVNIFRGHSSMSLQDAQE 1880

  Fly  1827 ------NTTE------NPLWIEQKLKLYEEQELTMQVFSEPDHISNSEAPGHLDHRSSLEQ---- 1875
                  ||.:      ||:|    ||.|:.:..            .||..|.:....||:.
  Fly  1881 PATRVPNTNKHSVQGSNPIW----LKGYDNEWF------------KSEESGSIGGHDSLDDNFLA 1929

  Fly  1876 --VHHVGQTVDNTYATIQPRNNQNR 1898
              ...:.:|:..|.......|:.||
  Fly  1930 VATQDMHETLKGTAKLFNNSNDLNR 1954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	27/104 (26%)
		Cadherin_repeat	136..240	CDD:206637	24/117 (21%)
		Cadherin_repeat	248..353	CDD:206637	40/105 (38%)
		Cadherin_repeat	362..468	CDD:206637	35/111 (32%)
		Cadherin_repeat	476..>533	CDD:206637	27/57 (47%)
		CA_like	<627..667	CDD:481204	10/39 (26%)
		CA	692..772	CDD:214520	27/106 (25%)
		Cadherin_repeat	778..873	CDD:206637	34/103 (33%)
		Cadherin_repeat	882..994	CDD:206637	36/121 (30%)
		Cadherin_repeat	1015..1099	CDD:206637	20/88 (23%)
		Cadherin_repeat	1108..1207	CDD:206637	36/104 (35%)
		Cadherin_repeat	1215..1314	CDD:206637	27/103 (26%)
		Cadherin_repeat	1327..1427	CDD:206637	32/100 (32%)
		Cadherin_repeat	1437..1549	CDD:206637	35/182 (19%)
		Cadherin_repeat	1557..1662	CDD:206637	28/110 (25%)
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637	25/96 (26%)
		Cadherin_repeat	179..276	CDD:206637	22/112 (20%)
		Cadherin_repeat	287..388	CDD:206637	40/103 (39%)
		Cadherin_repeat	397..506	CDD:206637	35/111 (32%)
		Cadherin_repeat	514..617	CDD:206637	39/189 (21%)
		Cadherin_repeat	625..742	CDD:206637	32/123 (26%)
		Cadherin_repeat	751..853	CDD:206637	34/101 (34%)
		Cadherin_repeat	865..976	CDD:206637	36/121 (30%)
		Cadherin_repeat	985..1080	CDD:206637	20/94 (21%)
		Cadherin_repeat	1090..1191	CDD:206637	36/103 (35%)
		CA	1221..1302	CDD:214520	26/81 (32%)
		Cadherin_repeat	1312..1409	CDD:206637	31/99 (31%)
		Cadherin_repeat	1418..>1502	CDD:206637	20/83 (24%)
		Cadherin_repeat	1617..1710	CDD:206637	26/101 (26%)