DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and cdh23

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_999974.1 Gene:cdh23 / 407978 ZFINID:ZDB-GENE-040513-7 Length:3366 Species:Danio rerio


Alignment Length:2104 Identity:593/2104 - (28%)
Similarity:941/2104 - (44%) Gaps:330/2104 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 IILYENVTVGTVVFRLEA------------YDPEGSPVTYGAIGADHFSVDPVSGNITLIKPLDR 86
            :.|.||:..||.|.:::|            :||:.||.....     |.:|.|:|.||:...|||
Zfish  1323 VSLRENIATGTEVVQVKAQSADNLNQLSYRFDPDTSPAALAL-----FKIDSVTGRITVTGLLDR 1382

  Fly    87 EEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDNPPEFQNT-PYEADVNEDAAVGTT 150
            |..|:....|     |..:|..:|.:.|:|.||  |||.|||.|||..| ....::.||.|:|..
Zfish  1383 ERGDSYTLTV-----VADDGGPKRGSTVKVSIT--ILDENDNSPEFDITSDLSVNIPEDTAIGKR 1440

  Fly   151 IFDKITVKDRD-----------IVGESLDLKCLPQQQSPEACRKFRLHIIKRDATILEAAVVLND 204
            : ..:..:|:|           |.|...|:              |:::.:..    ....|.||.
Zfish  1441 V-AVVLARDKDAGRNGLVNFTLIAGNMQDV--------------FKINTVNN----TYGEVYLNA 1486

  Fly   205 TLNYNQRMVYHFQIEATDG---PHKTQTTFEARVKDVQDKPPVFQG--SLSTVIDEDSPINTLVL 264
            .|:......|..::.|.|.   |..|..:....:.||.|.|||.|.  ..:..:.|:....|.||
Zfish  1487 PLDRESVDRYLLKVRAMDNGSPPRYTDVSLTVNIVDVNDNPPVLQSPRGYNVSVSENVGGGTSVL 1551

  Fly   265 TVHARDGDTGEPRKIVYDLRTNPNDY-FLLDAQTGELRT-AKPLDREALEDSTGIISLVIRAREL 327
            .|.|.|.|.|....:.|.:.....|. |.:|..|||:.| ..|.|||..:..|..:::       
Zfish  1552 RVVATDRDIGANAMLSYYITAGNQDLTFRMDRMTGEIVTRPSPPDREKQQQYTLTVTV------- 1609

  Fly   328 VNGVPSDDPLTSATAKATVTIR--DVNDSPPVFNHKEYSVSLLENTLPGTPLALDMSVS--DADV 388
                 .||...:.:...||.:|  |.||:.|.|..:||...|.|.  |.|..|:..:|:  |.|.
Zfish  1610 -----EDDGTPTLSTSTTVWVRIIDENDNAPEFPEEEYVTELREG--PNTVGAIIATVTAIDPDE 1667

  Fly   389 GINS--KFALRLDDVSGVFDVEPKLVTGYSQVNIRVANGTLDYENPNQRKFIVLVVAEETDTNP- 450
            |:|.  ::|:...:::..|.:..  |||  |:   |....||||..|.. :::.|.|  ||..| 
Zfish  1668 GLNGTIRYAISKGNLAQTFQINS--VTG--QI---VVVSALDYEISNGH-YVLTVTA--TDQCPI 1722

  Fly   451 ---RLSSTATITVSVLDANDNKPVFEQESYSASVSEAALPGQYIATITARDVDSGSYGDSGIRYS 512
               ||:|:.|:.|:|:|.|||.|:|.:............||..:.|:.|.|.||||.|.  :.||
Zfish  1723 PLLRLTSSTTVLVNVIDVNDNPPIFPRPFEGPFEITEGQPGPRVWTVKATDADSGSNGK--VEYS 1785

  Fly   513 LSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIG 577
            :  |..:|    :...|||      :.|...|.|:|:..|...        :...::....:::|
Zfish  1786 I--TAGDL----KNEFVIS------SVEGELRVRKDIELDRET--------IAYYNITITAKDLG 1830

  Fly   578 TEPTVQYT-----LITQAPEEQASSVPLPAPVPHAAPSGVPAATANDDKAPQTCL------DYES 631
            | |::..|     |:....:.....:.|||           ..:.::..|.||.:      |.:|
Zfish  1831 T-PSLNATVVVGILVLDINDNDPILLNLPA-----------NTSVSEGAAVQTFIIQVRAQDSDS 1883

  Fly   632 ETTYFLSYKATDDNGRG------SASVVS-----------------------------------L 655
            .....|:|..|..|..|      ::.||.                                   |
Zfish  1884 GRNALLTYSITAGNSDGAFYINETSGVVQVNRPLDRERVAEYSLTITVKDNPDNPRIARRDSELL 1948

  Fly   656 RISVTDANDSPPVCESPLYRASVDEGA------VVFDSPLIVKARDADTMSRISYRIRGSEQVES 714
            .:::.|.||:.|:.....||..:.|.:      ::.:.|::.:.:|....:.:||.:.|:.  ..
Zfish  1949 TVTLLDVNDNRPIFSQSSYRGEISENSPTGTTVLILNGPVLAEDKDIGVNAVVSYGLLGTR--VD 2011

  Fly   715 IFDIDRETGQIIIRPNATLDVTNLNSDQL-IFAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQS 778
            ||.||..||.:.:|..|.||....:..:: :|.|..:.|...:...:.||:.|||::.|.|...|
Zfish  2012 IFSIDSRTGVVSVRGGAVLDREAFSVPRVELFLVSVDVGGLNSSVPLTITILDVNDNPPVFNPSS 2076

  Fly   779 YSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDDFGIVETTGEVFV-SRKLDFDRRN 842
            ::..:.|||..|..|.::.|||.|.|.|..|:||:..|:.|.|.:...:|.|.| :..||.:.|:
Zfish  2077 FTVRLPENSPTGVVVTQLSATDADAGSNGWLQYRLDSGAQDRFIVDALSGAVLVGNATLDREERS 2141

  Fly   843 TYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDV 907
            :|:|.:.|:|:|||||:||||||:.:.:.||..|.|:...|...|....|||.:|.||.|.|||:
Zfish  2142 SYRLVVIATDRGTPSLSGTATLTVVLDDVNDSRPRFIQPVQTISVNESTPPGVVVATLAAEDPDL 2206

  Fly   908 ANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKIS-RNGKVSVNKQLDRNLFAVMRINVLVTD 971
            ...  ||:.    |.:::.:.......|..::.|.|. ..|.|.|...|:|.|.|...|.|.|.|
Zfish  2207 KPR--LEYY----IISVEAKDDGNNAVDGLQQSFGIDFHTGAVFVRNPLNRELVATFEIIVSVHD 2265

  Fly   972 S---------TAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQ 1027
            :         :.||.:     |.|.::|||.|.|||. |:.|  ......::|....||.|.::.
Zfish  2266 NASDVIEMSVSVPNAK-----LTINVLDVNDNAPRFR-PFGV--ANFSESILEGAVPGTTLLSVT 2322

  Fly  1028 ANDEDSS-IGE-----FNISDNDYFAINQTS-GMIYTIARLDYEVVKEVKFQVTVSDTGVPALTA 1085
            |.|.|.. .|:     .|:...:|..:...| |.|.....:|:|.|:.:.|.|...|.|.|....
Zfish  2323 AVDPDKGPNGQIIYQLLNLPRGNYIRLEDPSTGKIVANRTVDFEQVQWLNFTVRAQDHGSPPRFT 2387

  Fly  1086 TADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYF 1150
            ...|.:.||::|||:|.|.|..|..::.|:...||:...|.|.|.|.|:|..|.|.|:....| |
Zfish  2388 ELPVYLRIIDVNDNNPVFQQPLYQKSIFEDVALGTIIVSVRATDADSGLFSVIEYGLVDGEGK-F 2451

  Fly  1151 SIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAV--QKSATATIHINILDVNDNAPVFTR 1213
            .|...||::.:.  |.||||.....||:..|:|....:.  ::..:..:.:.:|||||..|.|:.
Zfish  2452 GITPTTGDIYIL--SALDRETKDRYTLTAYARDNPGGSPNNRRENSVQVQLTVLDVNDFRPRFSE 2514

  Fly  1214 DVYNSTVAENAAYQP-PAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLS 1277
            .|:.::|.||   :| ..:::.::|.|.|||....:.|.: .|.....|.||..:|::...:.|.
Zfish  2515 RVFTTSVFEN---EPVGTSVITMKATDLDEGENALLTYSL-QGPGADAFSLDPDTGLIRSLRLLQ 2575

  Fly  1278 GKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATI-----EIPGDIVQP 1337
             ....:.||:.|.| ||...:..|....|||:.||.::|.||.||  |.||     |.|     |
Zfish  2576 -SFERFNLTVVATD-QGRPPLWGTASLQITVIDVNDNRPIFVRPA--NGTIMHILEEQP-----P 2631

  Fly  1338 DYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNRANYDIILV 1402
            ..::..|.|.|.|...||:|.|.........:....|.||.|||.:....:|:|:.:|.|.:::|
Zfish  2632 GLVVYEVFATDEDEGVNGEVRYSFLQTGAGNRDWENFHIDAVTGVITTAVKLDREKQALYSLVVV 2696

  Fly  1403 ARDAGNP-PFESLRLLSVSIVDANENRPEF---PDASNPYK-VSINENSGRDVKIGHIQ-AASRS 1461
            |.|.|.| |:|:::.|.|::.|.::|.|.|   |..|.||: :|:.|:|.....:|::. |....
Zfish  2697 AYDLGQPVPYETMQPLQVALSDIDDNEPVFLKPPRGSLPYQSLSVPEHSSPGTVVGNVTGAVDAD 2761

  Fly  1462 KHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADLHISEEERAS-F 1525
            :.:..|.||.:.|.:.|..:...::|.:...|.|||||..||::.:.||...:....:.:|:. .
Zfish  2762 EGSNAIVYYFIAGGDTGGNFALSVSGVLRVKKDLDREEIPVYSIIVKASSNRNWTPPKGQRSQRA 2826

  Fly  1526 SIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNATDADQGKNAKIEF 1590
            .:...:||.|:.:|.|.:.|:||..|.|.|..|..||.|:||:|:.:..|.|.|.|.|.|:.:.:
Zfish  2827 QVLDPSRDPTLQEVRIFLEDINDQSPRFTKLEYTTGVAADAKVGSDLIRVQAIDNDIGNNSLVLY 2891

  Fly  1591 MIVASNLYKFGATKS--TGSIVPSPFAISQ-DGRISANTIMAEYNQDRFELEIVARELEQPQSSA 1652
            .|::....|..:..|  .|::    |.|.: ||.|....:...|....|.:|::||:|......|
Zfish  2892 HILSIRYIKLHSNDSEEMGNV----FIIGETDGIICTFDLFMAYAPGYFIVEVLARDLAGHSDVA 2952

  Fly  1653 STKVNIWVFDGTQLVRVILSRPPEEVYQEQEEIIAELRNATQHRIIVDEIRFHLDSIGRIRMDWC 1717
              .|:|::....|.|:::::..||.|...|||.|..|.|.|...:..|:::||:|..||:.....
Zfish  2953 --LVSIYILRDDQRVKIVINEIPERVRLFQEEFINLLSNITGAIVNTDDVQFHVDKKGRVNFAQT 3015

  Fly  1718 DLYFHAVDPQTQQIAPVDEILKDIDRNYDYLKDYYAGFAIENVVPAYIAIVQDEFDLAVAGLVAL 1782
            |:..|.|:.||.:|..|:::::.||.|.:.|::.:..:.|.:|.||..|...|:.......::.|
Zfish  3016 DVLIHVVNKQTNRILDVEKVIQMIDENKEQLRNLFRNYNILDVQPAVTARAPDDLTTLQMAIIIL 3080

  Fly  1783 VIVLFVGVISFIVLCCCLKHWNLSVPVETRRKEALIK--------KQIIEDLNTTE------NPL 1833
            .::||:..:.||     |.:|.... |..|:.:|::.        ..|::..||.:      ||:
Zfish  3081 AVLLFLAAMLFI-----LMNWYYRT-VHKRKLKAVVAGSTGNQGLMDILDMPNTNKYTFEGANPV 3139

  Fly  1834 WIEQKLKLYEEQELTMQVFSE---PDHIS------NSEAPGHLDHRSSLEQVHHVGQTVDNTY-- 1887
            |::   ......||..|...|   |:.:|      ||.|..|    .:..:.....:..|:.|  
Zfish  3140 WLD---PFCRNLELAAQAEHEDDLPEDLSDIADLWNSPARTH----GTFGREPQATKPEDDRYLR 3197

  Fly  1888 ATIQPRNNQNRLTGGGGAGGGSMRSGGGASAGGVGGAGLLLARVDPHMNEFADYATLRNNRAPSL 1952
            |.||..:|..:|       |..||.      |.:.|: ||...:|       ||..|:...|..|
Zfish  3198 AAIQEYDNIAKL-------GQIMRE------GPIKGS-LLNVVLD-------DYLRLKKLFAARL 3241

  Fly  1953 YEFTGSTFQAPIRDGD-DAVAELI 1975
              .|.||.|     || .:|.|||
Zfish  3242 --VTKSTSQ-----GDRSSVTELI 3258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 34/105 (32%)
Cadherin_repeat 136..240 CDD:206637 21/117 (18%)
Cadherin_repeat 248..353 CDD:206637 28/108 (26%)
Cadherin_repeat 362..468 CDD:206637 37/113 (33%)
Cadherin_repeat 476..>533 CDD:206637 17/56 (30%)
CA_like <627..667 CDD:481204 13/86 (15%)
CA 692..772 CDD:214520 22/80 (28%)
Cadherin_repeat 778..873 CDD:206637 39/95 (41%)
Cadherin_repeat 882..994 CDD:206637 36/121 (30%)
Cadherin_repeat 1015..1099 CDD:206637 25/90 (28%)
Cadherin_repeat 1108..1207 CDD:206637 31/100 (31%)
Cadherin_repeat 1215..1314 CDD:206637 29/99 (29%)
Cadherin_repeat 1327..1427 CDD:206637 33/105 (31%)
Cadherin_repeat 1437..1549 CDD:206637 31/114 (27%)
Cadherin_repeat 1557..1662 CDD:206637 31/107 (29%)
cdh23NP_999974.1 Cadherin_repeat 48..134 CDD:206637
Cadherin_repeat 142..237 CDD:206637
Cadherin_repeat 246..350 CDD:206637
Cadherin_repeat 358..460 CDD:206637
Cadherin_repeat 469..561 CDD:206637
Cadherin_repeat 570..671 CDD:206637
Cadherin_repeat 679..778 CDD:206637
Cadherin_repeat 786..890 CDD:206637
Cadherin_repeat 898..994 CDD:206637
Cadherin_repeat 1003..1102 CDD:206637
Cadherin_repeat 1110..1206 CDD:206637
Cadherin_repeat 1221..1311 CDD:206637
Cadherin_repeat 1321..1417 CDD:206637 34/105 (32%)
Cadherin_repeat 1428..1526 CDD:206637 21/116 (18%)
Cadherin_repeat 1536..1633 CDD:206637 29/108 (27%)
Cadherin_repeat 1641..1743 CDD:206637 37/113 (33%)
Cadherin_repeat 1755..1850 CDD:206637 27/117 (23%)
Cadherin_repeat 1858..1958 CDD:206637 17/110 (15%)
Cadherin_repeat 1966..2068 CDD:206637 26/103 (25%)
Cadherin_repeat 2076..2172 CDD:206637 39/95 (41%)
Cadherin_repeat 2181..2292 CDD:206637 36/121 (30%)
Cadherin_repeat 2304..2401 CDD:206637 25/96 (26%)
Cadherin_repeat 2410..2507 CDD:206637 30/99 (30%)
Cadherin_repeat 2516..2610 CDD:206637 29/99 (29%)
Cadherin_repeat 2624..2722 CDD:206637 31/102 (30%)
Cadherin_repeat 2738..2849 CDD:206637 28/110 (25%)
Cadherin_repeat 2858..2959 CDD:206637 31/106 (29%)
Blue background indicates that the domain is not in the aligned region.

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