back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad87A and shg

DIOPT Version :10

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster

Alignment Length:	1758	Identity:	366/1758 - (20%)
Similarity:	607/1758 - (34%)	Gaps:	522/1758 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 NDSPPVFNHKEYSVSLLENTLPGTPLALDMSVSDADVGINSKFALRLDDVSGVFDVEPKLVTGYS 416
            |..|...|...|:..:.|.. |.....|.:...|.|    ....:|...|...|: .||.....|
  Fly    82 NRKPAFKNCAGYAPKVKEEQ-PENTYVLTVEAVDPD----PDQVIRYSIVQSPFE-RPKFFINPS 140

  Fly   417 QVNIRVANGTLDYENPNQRKFIVLVVAEETDTN-PRLSSTATITVSVLDANDNKPVFEQESYSAS 480
             ..:.....|.|.:.|...|| |.|..:.||.. |.|....|..|::.|.|||.|.|.:..|..|
  Fly   141 -TGVIFTTHTFDRDEPIHEKF-VFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDES 203

  Fly   481 VSEAALPGQYIATITARDVDSGSYGDSGIRYS-LSGTGAELFHVNEQTGVISLANCHDNGESNRR 544
            :||.|.|...:.||:|.|.|.|:  :|.:.|. |.....:.|.:::::|:|.|
  Fly   204 MSENAQPDAVVMTISASDFDDGN--NSLVEYEILRERDFQYFKIDKESGIIYL------------ 254

  Fly   545 ERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAP 609
                                        .|.|...|...|.:|.:|    .:.||.|
  Fly   255 ----------------------------KRPIDKRPGQSYAIIVRA----YNVVPDP-------- 279

  Fly   610 SGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLY 674
                         ||.                         :.:.:||.|.:::..||...:|:
  Fly   280 -------------PQD-------------------------AQIEVRIRVVESSIKPPSFVNPI- 305

  Fly   675 RASVDEGAVVFDSPLIVKARDADTMSRISYRIRGSEQV-------ESIFDIDRETG--------- 723
                       |:|:.:|    :.:...::.|.....|       |.||:::  ||
  Fly   306 -----------DTPIYLK----ENLKNFTHPIATLRAVSNMPDKPEVIFELN--TGRTEQTNSKN 353

  Fly   724 ---------QIIIRPNATLDVTNLNSDQLIFAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSY 779
                     ::.|....|||...:....|...|.....|.|.| .:.|.|.|||:::|.:.:..
  Fly   354 TFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEH-QIKIQVEDVNDNIPYYTEVK- 416

  Fly   780 SAVVEENSEIGTSVERVHATDLD-TGKNAELRYRIQQGSFDDFGIVETTGEVFVSRKLDFDRRNT 843
            |..:.||...||.|.:|.|.|:| |..|..:.:.:.... :.|.|...||.:......|.:.|:.
  Fly   417 SGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADNR-EYFTIDPNTGNITALTTFDREERDF 480

  Fly   844 YQLQIQASDQGTPSL-------TGTATLTINVQNSNDKDPYFVPATQHAE-VRADAPPGQLVYTL 900
            |.:::.|||....||       .|.....|::.:.||..|:|......|| :..||.....|..:
  Fly   481 YNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEV 545

  Fly   901 IALDPDVANH--NALEFAGTDDITAIDKEGKELPHYDQFKEYFKIS-RNGKVSVNKQLDRNLFAV 962
            .|.|.|.|:.  .::|.....|.                   |||. :.||::||::||......
  Fly   546 KAEDEDNASQILYSIESGNVGDA-------------------FKIGLKTGKITVNQKLDYETITE 591

  Fly   963 MRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQ 1027
            ..:.|...|    .:......::|:|.|||.|||.|...:||       .::||......:.|::
  Fly   592 YELKVRAFD----GIYDDYTTVVIKIEDVNDNPPVFKQDYSV-------TILEETTYDDCILTVE 645

  Fly  1028 ANDEDSSIGEFNISDNDYFAINQTSGMIYTIARLD-YEVVKEV---------KFQVTV---SDTG 1079
            |.|.|  |.:.|...:..::|:|..|..:||.... ..:||.:         .:||.:   .:.|
  Fly   646 AYDPD--IKDRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDG 708

  Fly  1080 VPALTATA-DVVVDIINLNDNDP-KFSQSDYYFNVTENSPRGTVAGKVEAHD-GDVGVFGEITYT 1141
            |....:|. :|.|.:.::|||.| ..::...|:.  ||...|.|. :::|:| .|....|..|:.
  Fly   709 VGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQ--ENRNPGHVV-QLQANDYDDTPGAGNFTFG 770

  Fly  1142 LIGEN----NKYFSIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINIL 1202
            :..|.    ...||:|   |:.:.||.. .|||..||..:.:...|.  ...::||.:.:|:.|.
  Fly   771 IDSEATPDIKTKFSMD---GDYLHANVQ-FDREAQKEYFIPIRISDS--GVPRQSAVSILHLVIG 829

  Fly  1203 DVNDNA------PVFTRDVYNSTVAENAAYQ---PPAALLQVQAIDQDEGLYGDVRYIITAGNEM 1258
            ||||||      .:|   :||        |:   |...:.:|...|.|:....| :|........
  Fly   830 DVNDNAMSEGSSRIF---IYN--------YKGEAPETDIGRVFVDDLDDWDLED-KYFEWKDLPH 882

  Fly  1259 GLFKLDAQSG----IVYPAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFV 1319
            ..|:|:..:|    :|:.|:      |.|:|:...  |:.|             :.|.||..:
  Fly   883 DQFRLNPSTGMITMLVHTAE------GEYDLSFVV--TEDS-------------MFVPRHSVD-- 924

  Fly  1320 IPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELR 1384
                              .|:.:.||.:..:..:                ::|..:...||.|
  Fly   925 ------------------AYVTVVVRELPEEAVD----------------KSGSIRFINVTKE-- 953

  Fly  1385 AKTQLNRKNRANYDIILVARDAGNPPFESL--RL---------LSVSIVDANENRPEFPDASNPY 1438
                         :.|.|.||..:|...||  ||         .|||.||.             :
  Fly   954 -------------EFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDV-------------F 992

  Fly  1439 KVSINENSGRDVKIGHIQAASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVY 1503
            .|..|||...||:.        |.|...  ||.          .:||.|.:..|:.....|.|:.
  Fly   993 TVLQNENHTLDVRF--------SAHGSP--YYA----------PEKLNGIVAQNQQRLENELDLQ 1037

  Fly  1504 TLYI------LASIKADLHISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGV 1562
            .|.:      :...|.:...:.|...| |:..:...||.:.|.:...  .....|.|.|:....:
  Fly  1038 MLMVNIDECLIEKFKCEESCTNELHKS-SVPYMIYSNTTSFVGVNAF--VQAQCVCEAPLMRRCL 1099

  Fly  1563 NANAKMGAAITLVNATDADQGKNAKIEFMIVASNLYKF-------GATKSTGSIVPSPFAISQD- 1619
            |..:.......:.:..|...|.:.::..:....:.|.|       ..||.:..|.|.   |.|.
  Fly  1100 NGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQ---IDQGL 1161

  Fly  1620 ----GRISANTIMAEYNQDRFELEIVARELEQPQSSASTKVN----IWVFDGTQLVRVILSRPPE 1676
                |.::.|.::|..:....||:.....|.....|.:.::.    ..|.|.|..:.:||.|
  Fly  1162 IMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQR--- 1223

  Fly  1677 EVYQEQEEIIAELRNATQHRIIVDEIRF-----------------------------HLDSIGRI 1712
                            |...:.||..|.                             .|:.:||
  Fly  1224 ----------------TSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGR- 1271

  Fly  1713 RMDWCDL-----YFH-----AVDPQTQQIAPVDEILKDIDRNYDYLKDYYAGFAIENVVPAYIAI 1767
            :::|..:     :|.     .::.||..:. :..:.::||....           ::|..|:...
  Fly  1272 QLNWTHVPNQKGFFGCIRNLTINEQTYNLG-MPSVFRNIDSGCQ-----------QSVAVAFSFG 1324

  Fly  1768 VQDEFDLAVAGLVALVIVLFVGVISFIVLCCCLKHWNLSVPVETRRKEALIKKQIIE-------- 1824
            :...|.:|:...:||::::.:.|:                 |:.::|....:|.|.:
  Fly  1325 IDRNFIIAIIVCLALLLIILLAVV-----------------VQKKQKNGWHEKDIDDIRETIINY 1372

  Fly  1825 ------------DLNTTENPLWIEQKLKLYEEQELTMQVFSEPDHISN-SEAPGHLDHRSSLEQV 1876
                        |||......:.|:  |||::.........:|:.|.: ::..|  |.:.:.::
  Fly  1373 EDEGGGERDTDYDLNVLRTQPFYEE--KLYKDPHALQGNMRDPNDIPDIADFLG--DKKENCDR- 1432

  Fly  1877 HHVG-QTVDNT--YATIQPRNNQNRLTGGGGAGGGSMRSGGGASAGGVGGAGL-LLARVDPHMNE 1937
             .|| .|||:.  ||           ..|.|...||:.|  .||....|.... .|:...|...:
  Fly  1433 -DVGATTVDDVRHYA-----------YEGDGNSDGSLSS--LASCTDDGDLNFDYLSNFGPRFRK 1483

  Fly  1938 FAD 1940
            .||
  Fly  1484 LAD 1486

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.