Protein Alignment Cad87A and CadN2

DIOPT Version :10

• Sequence 1: NP_731649.2
• Gene: Cad87A / 41441
• FlyBaseID: FBgn0037963
• Length: 1975
• Species: Drosophila melanogaster
• Sequence 2: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Alignment Length: 1563
• Identity: 360/1563 - (23%)
• Similarity: 573/1563 - (36%)
• Gaps: 430/1563 - (27%)

  Fly   655 LRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVKARDADTMSRISYRIRGSEQVESIFDID 719
            :||.:.|.|||||..:..||...:||.|.:..:.|.|.|:|.:..:.|.|:|.|. .:.:.|.:.
  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITGG-NIGNAFAVQ 85

  Fly   720 RETGQIIIRPNATLDVTNLNSDQLIFAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVV- 783
            ..||.|.:.  :.||.......:|  .:||.......:..|.|.|||||::.|.|::|:|...:
  Fly    86 NTTGVIYVA--SPLDYETRPRYEL--RLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQIT 146

  Fly   784 -EENSEIGTSVERVHATDLDTGKNAELRYRIQ-QGSFDD------FGIVETTGEVFVSRKLDFDR 840
             |::..:...:.:|.|||.|..:...:.|.:. ||...|      |.|..|||::||.:.||.|:
  Fly   147 EEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQ 211

  Fly   841 RN---TYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLIA 902
            .|   .::..:.|.|:|...|.|.|.:.:|:::.||..|.|........|..:...|..|.|:.|
  Fly   212 PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSA 276

  Fly   903 LDPDVANHNALEFAGTDDITAIDK----EGKELPHYDQFKEYFKISRNGKVSVNKQLDRNLFAVM 963
            :|.|..|    |......|.:|:|    |....|.::...|...|    |.:| ..|||......
  Fly   277 VDYDDPN----ESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLI----KTAV-CCLDRERTPDY 332

  Fly   964 RINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNA-PWSVEQPQIKLQMVEEQPVGTVLTTLQ 1027
            .|.|:..|...   .:|.|...|::.|:|..||:|.. .|..|..:.....:.|.|:.||  |:|
  Fly   333 SIQVVAMDGGG---LKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTV--TVQ 392

  Fly  1028 ANDEDSSIGEFNISDN-----DYFAI---NQTSGMIYTIARLDYEVVKE---VKFQVTVSDTGVP 1081
            ..||.::. ::.:..|     |.||:   ...:|.:..|..||||...:   .:|::.|:|.|..
  Fly   393 DEDETNTF-QYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDD 456

  Fly  1082 A-------LTATADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEIT 1139
            .       ..|.:.|||.:.::|||.|||.:.....::.|::..||:..:.:|.|.|.|...::.
  Fly   457 GPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVA 521

  Fly  1140 YTLIGENN--KYFSIDAYTGNVMVANSSILDREQIKELTLSVVA-QDKAPAAVQKSATATIHINI 1201
            |.::...|  :.|:| :..|.|.:...  ||||......:.::| .|.:||   ::||||:.:.:
  Fly   522 YKIVRSTNRKRQFAI-SDRGAVSIQRP--LDRETQDRHHIQILAIDDGSPA---RTATATLTVIV 580

  Fly  1202 LDVNDNAPVFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEGLYGD------------------- 1247
            .|||||||.|.:| |..|:.||.:.:   .:|:|.|.|.|:.|.|:
  Fly   581 KDVNDNAPTFAQD-YKPTLPENVSGK---KILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAG 641

  Fly  1248 --VRYIITAGNEMGL--------FKLDAQSGIVYPAQSLSGKHGAYELTISARDTQGSGTMESTT 1302
              |.|.....||.|:        |..:||.              :|.:.|..:| .|:..|..|:
  Fly   642 FKVEYDRRGDNENGVAIISSLRPFDREAQK--------------SYAIPIEIKD-NGAPAMTGTS 691

  Fly  1303 KAIITVLRVNRHKPEFVIPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKV---------- 1357
            ...:|:..||.:|.:             ||   ....|:...:....|| ..|:|
  Fly   692 TLTVTIGDVNDNKMQ-------------PG---SKSVLVYNYQGQSQDT-PIGRVYVNDPDDWDV 739

  Fly  1358 ---SYHLQVNNRNEQQTGEFKIDEVTG--ELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLL 1417
               .|:.:|     |:...||:|..||  .:||.|:     |..|.:.....|..:...:....|
  Fly   740 PDKKYYWEV-----QEHQRFKLDTDTGILTMRAGTR-----RGRYQLRFKVYDREHGQEDIPANL 794

  Fly  1418 SVSIVD--------ANENR------PEFPDASNPYKVSINENSGRDVKIGHIQAASRSKHNRDIF 1468
            ||::.|        |...|      .:|....||.|..:..                ||..|
  Fly   795 SVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEP----------------SKLER--- 840

  Fly  1469 YYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIK---ADLHI---SEEERASFSI 1527
                        :.:||...:||    ||:..||:::.:.....   .|:|.   |..::..|..
  Fly   841 ------------FRNKLAELLYT----DRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKA 889

  Fly  1528 KTLN------RDNTVAKVAITVLDVNDNPPVFE------------------KPIYYAGVNANAKM 1568
            ..||      |:.....|.:.:..||.|..:.|                  || |...||..|.:
  Fly   890 VRLNGVVQMHREEIEKDVGLNITMVNINECLHEGKGKCGSNSCTSKVELGKKP-YTVSVNRTALV 953

  Fly  1569 GAAITLV--------NATDADQGKNAKIEF------------MIVASNLYKFG-----ATKS--- 1605
            |..:.:.        |.|..|......:.:            ..||..:...|     :|:|
  Fly   954 GVRLDISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRSFRG 1018

  Fly  1606 TGSIVPSPFAISQDGRISANTI------MAEYN--------QDRFELEIVARELEQP-------- 1648
            .|.....|..:.|:..:|...|      :..||        ::....:.:|.||||.
  Fly  1019 NGWAWYPPLQLCQESHLSLEFITRVADGLILYNGPIVPPKPEETVISDFIALELEQGYPRLLIDF 1083

  Fly  1649 -----QSSASTKV----NIW----VFDGTQLVRVIL-------------SRPPE---EVYQEQEE 1684
                 :....||.    .:|    :|..|:.||:::             ..|||   ...|.:.:
  Fly  1084 GSGTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQ 1148

  Fly  1685 I--IAELRNATQHRIIVDEIRFHLDSI--------------GRIR-----MDWCDLYFHAVD--- 1725
            |  .||..|..|...:....|.|.|..              |.||     .:..||.|.|:.
  Fly  1149 IPPFAESLNLNQPLQLGGLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNS 1213

  Fly  1726 ----PQTQQIAPVDEILKDIDRNYDYLKDYYAGFAIENVVPAYIAIVQDEFDLAVAGLVALVIVL 1786
                |||.::.               ||       .|:....:      |....||.||.
  Fly  1214 FPACPQTDEVC---------------LK-------TEHTARCW------EHGNCVASLVQ----- 1245

  Fly  1787 FVGVISFIVLCCCLKHW---NLSVPV--ETRRKEALIKKQIIEDLNTTENPLWIEQKLKL-YEEQ 1845
                    ..|.|...|   ..:||.  .|.:.::.:|..:      :..|.....:|:| :..:
  Fly  1246 --------AKCHCQPGWMGPGCNVPTIPTTFKAQSYVKFAL------SFEPDRFSTQLQLRFRTR 1296

  Fly  1846 ELTMQVFSEPDHISNSEA-----PGHLDHRSSLEQVHHVGQTVDNTYATIQPRNNQ---NRLTGG 1902
            |...::|...|......|     .|||..|.:|..:.:..|.:  |...|...:.|   .|::..
  Fly  1297 EQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLL--TLTAIAVNDGQWHVIRISRY 1359

  Fly  1903 GGAGGGSMRSGGGASAGGVGGAGLLLARVDPHMNE---FADYATLRNNRAPSLY-----EFTG-S 1958
            |.|  ..|...||.|.               ..||   |..:..|..::...:|     |:|| .
  Fly  1360 GSA--ALMELDGGESR---------------RYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGIK 1407

  Fly  1959 TFQ 1961
            ||:
  Fly  1408 TFE 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		CA_like	<627..667	CDD:481204	6/11 (55%)
		CA	692..772	CDD:214520	22/79 (28%)
		Cadherin_repeat	778..873	CDD:206637	29/106 (27%)
		Cadherin_repeat	882..994	CDD:206637	29/115 (25%)
		Cadherin_repeat	1015..1099	CDD:206637	27/101 (27%)
		Cadherin_repeat	1108..1207	CDD:206637	28/101 (28%)
		Cadherin_repeat	1215..1314	CDD:206637	28/127 (22%)
		Cadherin_repeat	1327..1427	CDD:206637	26/122 (21%)
		Cadherin_repeat	1437..1549	CDD:206637	23/123 (19%)
		Cadherin_repeat	1557..1662	CDD:206637	28/167 (17%)
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	28/95 (29%)
		Cadherin_repeat	140..248	CDD:206637	30/107 (28%)
		Cadherin_repeat	256..359	CDD:206637	28/114 (25%)
		CA	388..483	CDD:214520	27/97 (28%)
		Cadherin_repeat	489..586	CDD:206637	28/102 (27%)
		Cadherin_repeat	594..703	CDD:206637	28/126 (22%)
		EGF_CA	977..1010	CDD:238011	3/32 (9%)
		LamG	1013..1198	CDD:238058	36/184 (20%)
		EGF_2	1233..1259	CDD:400365	8/44 (18%)
		LamG	1265..1426	CDD:238058	35/171 (20%)
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041