DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and Fat4

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_899044.3 Gene:Fat4 / 329628 MGIID:3045256 Length:4981 Species:Mus musculus


Alignment Length:1970 Identity:512/1970 - (25%)
Similarity:809/1970 - (41%) Gaps:411/1970 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 PPVF-TQTLNNIILYENVTVGTVVFRLEAYD-PEGSP--VTYGAI-GA-DHFSVDPVSGNITLIK 82
            |||| |.|| ::.:.||:..|:.:.:|.|.| .||:.  |||..| || |.|.:||.||::...|
Mouse  1737 PPVFPTDTL-DLTVEENIGDGSKIMQLTAMDADEGANALVTYALISGADDSFRIDPESGDLIATK 1800

  Fly    83 PLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDNPPEFQNTPYEADVNEDAAV 147
            .||||.:.....||    |.| :|....|..:.:.|:    |:||:.|.|....|..|:.||...
Mouse  1801 RLDREHRSKYSLLV----RAD-DGLQSSDMRINITIS----DVNDHTPRFSRPVYSFDIPEDTTP 1856

  Fly   148 GTTIFDKITVKDRDIVGESLDLKCLPQQQSPEACRKFRLHIIKRD-------ATILEAAVVLNDT 205
            |:.:...:...|...|...:.                  ::::.|       ..::.....|...
Mouse  1857 GSLVAAILATDDDSGVNGEIS------------------YVVEEDDGDGVFFLNLVTGVFNLTRA 1903

  Fly   206 LNYNQRMVYHFQIEATDGPHKTQTTFEA--RVKDVQDKPPVF-QGSLSTVIDEDSPINTLVLTVH 267
            |:|..:..|...:.|.||..:: ||..|  .:.||.|.|||| ..|.||.:.|:.|:.:.||..:
Mouse  1904 LDYETQQYYILTVRAEDGGGQS-TTIRAYFNILDVNDNPPVFSMSSYSTSLMENLPLGSTVLVFN 1967

  Fly   268 ARDGDTGEPRKIVYDLRTNPN-DYFLLDAQTGELRTAKPLDREALEDSTGIISLVIRARELVNGV 331
            ..|.|.|...::.|.:.:..: ..|.:| :.|.|:|.|.||||    |....:|||:..:|    
Mouse  1968 VTDADDGVNSQLSYSIASGDSLGQFAVD-KHGVLKTLKALDRE----SQSFYNLVIQVHDL---- 2023

  Fly   332 PSDDPLTS---ATAKATVTIRDVNDSPPVFNHKEYSVSLLENTLPGTPLALDMSVSDADVGINS- 392
              ..|.||   :||:.::.:.||||:||:|...:.:. :.||| |...:......:|.|.|.|| 
Mouse  2024 --PQPPTSRFTSTAQVSIILLDVNDNPPMFLSPKLTY-IPENT-PIDTVVFKAQATDPDSGPNSY 2084

  Fly   393 -----------KFALRLDDVSGVFDVEPKLVTGYSQVNIRVANGTLDYENPNQRKFIVLVVAEET 446
                       ||::      |..|.|..|            .|.||.|..:  .:.:.|||  |
Mouse  2085 IEYTLLNPSGNKFSI------GTIDGEVHL------------TGELDREEVS--NYSLTVVA--T 2127

  Fly   447 DT-NPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAALPGQYIATITARDVDSGSYGDSGIR 510
            |. .|.|||:..:.|.|||.|||.|||.|..|...:.|..|.|..|..::|.|.|.|:.|.  :|
Mouse  2128 DKGQPPLSSSTEVVVMVLDINDNNPVFAQAMYRVQIKENILTGTDIIQVSAADNDEGTNGQ--VR 2190

  Fly   511 YSL-SGTGAELFHVNEQTGVISLA---------------NCHDNGESNRRER-------RDLNED 552
            |.: .|...:.|.::..||.|::|               ...|.|.|.|.:.       .|:|:.
Mouse  2191 YGIVGGNTHQEFRIDSVTGAITVAKSLDRETTPAYTLTVQATDRGSSPRTDSCTVAITLLDMNDF 2255

  Fly   553 EHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLIT----QAPEEQASSVPLPAPVPHAAPSGVP 613
            ..|.|      |...|:. ....:||.|.....::.    |.|..|.|.|.|.....:|.     
Mouse  2256 VPVFE------LSPYSVN-VPENLGTLPRAILQVVARDDDQGPNSQLSYVLLGGNEDNAF----- 2308

  Fly   614 AATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASV 678
            ..||:.:......||.|:...:.|...|.|..........::.|.|.|.||:.|...:.:|..|:
Mouse  2309 VLTASGELRVTQSLDREARDHFVLVVTAADAGSPALTGTGTINIIVDDINDNVPTFANNMYLTSI 2373

  Fly   679 DEGAVVFDSPLIVKARDADTMSR--ISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTNLNSD 741
            .|.|......|:|.|.|||..:.  |||.|.|.   .|.|.|:..|||||  .:|.||  ....|
Mouse  2374 AEDARTGTDVLLVNASDADAAANAVISYSIIGG---NSQFTINPSTGQII--TSALLD--RETKD 2431

  Fly   742 QLIFAVEANDG----LFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLD 802
            .....|.|:|.    ..::...|.:|:.|||::.|.|:...|...:...:..|:.|..|..||.|
Mouse  2432 NYTLVVVASDAGSPESLSSSTSVLVTITDVNDNPPRFQHHPYVTHIPSPTPPGSFVFAVTVTDAD 2496

  Fly   803 TGKNAELRYRI------------------------------------QQGSF------------- 818
            .|.|:||.|.:                                    ..|||             
Mouse  2497 IGSNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLSGASEVTFSVHVKDGGSFPKTDSTTVTVRFA 2561

  Fly   819 --------------------------------------------------DDFGIVETTGEVFVS 833
                                                              |.|.|...||:|.:|
Mouse  2562 NKADFPKVRAKEQTFMFPENQPVGTLVTTITGSSLRGETLSYYIASGNLGDTFQIDPLTGQVSIS 2626

  Fly   834 RKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQLVY 898
            :.|||::...|.:.|:|.|.|.|..:....|.|.|.:.||..|.|......:|:..:..|.::: 
Mouse  2627 QPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDINDNAPTFEEDPFVSEILENLSPRKIL- 2690

  Fly   899 TLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSVNKQLDRNLFAVM 963
            |:.|.|.|...:..|::              |:.:.:|...:......|::...:.|||...:..
Mouse  2691 TVSATDKDSGPNGQLDY--------------EIVNGNQESSFTINHATGEIRSIRPLDREKISHY 2741

  Fly   964 RINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQA 1028
            .:.|..:|..:|: |.....:||.|:|.|.|.|||:..:|.       .:.|..|:|..:|.:..
Mouse  2742 ELTVKSSDKGSPS-QSTSVKVIISILDENDNAPRFSQIFSA-------YVSENSPLGYTVTRVTT 2798

  Fly  1029 NDED---SSIGEFNISDNDY-FAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADV 1089
            :|||   ::|..::|.|... |.||..:|.|.....|:.|.....:.:|:..|:|   .|.:.||
Mouse  2799 SDEDIGINAISRYSIVDTSLPFTINPNTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDV 2860

  Fly  1090 VVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYFSIDA 1154
            .:.:.::|||.|:||:..||.:..|....|:...:|.|.|.|.|..|::.| .|...::||.|:|
Mouse  2861 TIFVTDINDNTPRFSRPSYYLDCPELPELGSRVTQVSATDPDEGSNGQVFY-FIKSQSEYFRINA 2924

  Fly  1155 YTGNVMVANSSILDRE--------QIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVF 1211
            .||.:.  |..:|..:        .|...:..|.|.|:...::....|.|  ||.:|.|||.|.|
Mouse  2925 TTGEIF--NKQVLKYQNVSGFSNVNINRHSFIVTASDRGNPSLLSETTVT--INTVDSNDNPPQF 2985

  Fly  1212 TRDVYNSTVAENAAYQPPAALLQVQAI-DQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQS 1275
            .::.|.:.|.:|.  :....|::|.|: |:|.||..:|.|.::.||.:|.||||..:|.:..|.|
Mouse  2986 LQNKYFTPVTKNV--KVGTKLIKVTAVDDKDFGLNSEVEYFVSDGNHLGKFKLDNDTGWISIASS 3048

  Fly  1276 L-SGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIEIP-----GDI 1334
            | |..:..:.:.::|:| :|:..:.|.....|||...|.|.|||   :.::.:..||     |.:
Mouse  3049 LVSDLNQNFLIRVTAKD-KGNPPLSSQAVVHITVTEENYHTPEF---SQNHISATIPESHSIGSV 3109

  Fly  1335 VQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNRANYDI 1399
            |:      ||.|.|.||..||.:||::...|    :.|.|.|:..||.:.....|:.:..:.:::
Mouse  3110 VR------TVSARDRDTAMNGLISYNIISGN----EEGIFAINSSTGVVTLAKALDYEMSSKHEM 3164

  Fly  1400 ILVARDAGNPPFESLRLLSVSIVDANENRPEF-PDASNPYKVSINENSGRDVKIGHIQAASRSKH 1463
            .:.|.|.|.........|:||::|.|:|.|.| ||...|   ::.||:.....:.|:.|......
Mouse  3165 TISATDGGWVARTGYCSLTVSVIDVNDNSPVFVPDEFFP---TVMENAPSGTTVIHLNATDADSG 3226

  Fly  1464 NRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADLHISEEERASFSIK 1528
            ...:..|.:..::...|.:|...|.|.|...||.|....|.|    ::|| .::.:||:.||   
Mouse  3227 ANAVIAYTVQSSDSDLFVIDPNMGVITTQGFLDFETKQSYHL----TVKA-FNVPDEEKCSF--- 3283

  Fly  1529 TLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIV 1593
                    |.|.|.:...|:..|.|...:||..|:..|..|.|:..|.|:|.|.|.:.::.::| 
Mouse  3284 --------ATVDIQLKGTNEYVPRFVSKLYYFEVSEAASRGTAVGEVFASDRDMGADGEVHYLI- 3339

  Fly  1594 ASNLYKFGATKSTGSIVPSPFAISQ-DGRISANTIMAEYNQDRFELEIVARELEQPQSS--ASTK 1655
                  ||.::..|      |.|:: .|:|..:.::....::|..|:::|:.....:.:  ....
Mouse  3340 ------FGNSRKKG------FQINKMTGQIYVSGLLDREKEERVSLKVLAKNFGNIRGADIDEVT 3392

  Fly  1656 VNIWVFDGTQLVRVILSRPPEEVYQEQEEIIAELRNATQHRIIVDE---IRFHLDSIGRIRMD-- 1715
            |||.|.|...        ||             :.:.:.:|:.:.|   |..|:..:.....|  
Mouse  3393 VNITVLDAND--------PP-------------VFSLSTYRVQISEGVPIGTHVTFVSAFDSDSI 3436

  Fly  1716 --WCDL-YF---------HAVDPQTQQIAPVDEILKDIDRNYDYLKDYYAGFAIENVVPAY--IA 1766
              |... ||         .:::|||.||.    :...:||               ..:|.|  ..
Mouse  3437 PSWSRFSYFIGSGNENGAFSINPQTGQIT----VTSGLDR---------------ESLPVYNLTV 3482

  Fly  1767 IVQDEFDLAVAGLVALVIVL 1786
            :..|....:..|..:||:.|
Mouse  3483 LAVDSGTPSATGSASLVVTL 3502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 34/99 (34%)
Cadherin_repeat 136..240 CDD:206637 20/112 (18%)
Cadherin_repeat 248..353 CDD:206637 33/108 (31%)
Cadherin_repeat 362..468 CDD:206637 33/118 (28%)
Cadherin_repeat 476..>533 CDD:206637 17/57 (30%)
CA_like <627..667 CDD:481204 11/39 (28%)
CA 692..772 CDD:214520 29/85 (34%)
Cadherin_repeat 778..873 CDD:206637 34/193 (18%)
Cadherin_repeat 882..994 CDD:206637 22/111 (20%)
Cadherin_repeat 1015..1099 CDD:206637 24/87 (28%)
Cadherin_repeat 1108..1207 CDD:206637 30/106 (28%)
Cadherin_repeat 1215..1314 CDD:206637 32/100 (32%)
Cadherin_repeat 1327..1427 CDD:206637 29/104 (28%)
Cadherin_repeat 1437..1549 CDD:206637 26/111 (23%)
Cadherin_repeat 1557..1662 CDD:206637 26/107 (24%)
Fat4NP_899044.3 EGF_CA 4430..4464 CDD:238011
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4535..4585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4677..4713
Necessary and sufficient for interaction with MPDZ. /evidence=ECO:0000269|PubMed:19506035 4708..4797
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4753..4773
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4796..4911
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4957..4981
Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 904..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637
Cadherin_repeat 1105..1206 CDD:206637
Cadherin_repeat 1215..1311 CDD:206637
Cadherin_repeat 1321..1416 CDD:206637
Cadherin_repeat 1428..1525 CDD:206637
Cadherin_repeat 1540..1622 CDD:206637
Cadherin_repeat 1634..1736 CDD:206637
Cadherin_repeat 1747..1837 CDD:206637 34/98 (35%)
Cadherin_repeat 1845..1940 CDD:206637 20/113 (18%)
Cadherin_repeat 1948..2047 CDD:206637 34/109 (31%)
Cadherin_repeat 2057..2150 CDD:206637 33/116 (28%)
Cadherin_repeat 2159..2254 CDD:206637 23/96 (24%)
Cadherin_repeat 2263..2360 CDD:206637 23/102 (23%)
Cadherin_repeat 2369..2464 CDD:206637 35/101 (35%)
Cadherin_repeat 2472..2559 CDD:206637 15/86 (17%)
Cadherin_repeat 2573..2667 CDD:206637 20/93 (22%)
Cadherin_repeat 2675..2771 CDD:206637 22/111 (20%)
Cadherin_repeat 2778..2870 CDD:206637 25/101 (25%)
Cadherin_repeat 2878..2981 CDD:206637 30/107 (28%)
Cadherin_repeat 2990..3085 CDD:206637 31/97 (32%)
Cadherin_repeat 3095..3192 CDD:206637 29/106 (27%)
Cadherin_repeat 3200..3295 CDD:206637 25/113 (22%)
Cadherin_repeat 3305..3402 CDD:206637 27/109 (25%)
Cadherin_repeat 3410..3508 CDD:206637 22/112 (20%)
Cadherin_repeat 3516..3612 CDD:206637
EGF_CA 3804..3862 CDD:238011
EGF_CA 3864..3900 CDD:238011
EGF_CA 3902..3938 CDD:238011
EGF_CA 3941..3976 CDD:238011
LamG 3979..4142 CDD:238058
EGF_CA 4168..4200 CDD:238011
Laminin_G_2 4252..4375 CDD:460494
Blue background indicates that the domain is not in the aligned region.

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