DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and Cdh16

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_001012055.1	Gene:	Cdh16 / 307614	RGDID:	1311638	Length:	830	Species:	Rattus norvegicus

Alignment Length:	712	Identity:	168/712 - (23%)
Similarity:	267/712 - (37%)	Gaps:	190/712 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 EGSPVTYGAIGA---DHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEV 116
            ||..|..|..|.   :.|:|||.||.:...:.||||||...:..|::        |||...|:..
  Rat    54 EGQIVLSGDSGTAAENTFAVDPDSGFLVATRALDREEKAEYQLQVTL--------ESEDGQVLWG 110

  Fly   117 P--ITFIILDLNDNPPEFQNTPYEADVNEDAAVGTTIFDKITVKDRDIVG-ESLDLKC-----LP 173
            |  :|..:.|.||..|:|....|.|.:::....|.. |..:.|.|.|..| .:.||:.     .|
  Rat   111 PQLVTVHVKDENDQVPQFSQAIYRAQLSQGTRPGVP-FLFLEVSDGDAPGTTNSDLRFHILSQFP 174

  Fly   174 QQQSPEACRKFRLHIIKRDATILEAAVVLNDTLNYNQRMVYHFQIEATDGPHKTQTTFEARVKDV 238
            .|..|:   .|:|     |..:...|:..:.:...:..:..|:|:             ..:|||:
  Rat   175 VQPLPD---MFQL-----DPQLGALALSPDGSTTLDHALEEHYQL-------------LVQVKDM 218

  Fly   239 QDKPPVFQG----SLSTVIDEDSPINTL-------------VLTVHARDGDTGEPRKIVYDLRTN 286
            .|:|...|.    .:|.|.:..:|:..:             :..||...||      :.|.|.:.
  Rat   219 GDQPSGHQAMATLEISIVENSWTPLEPVHLAENLRVAYPHSIAQVHWGGGD------VHYQLESQ 277

  Fly   287 PNDYFLLDAQTGELRTAKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDV 351
            |...|.:||: |.:.....|||||..:    ..|.:||:. ..|....:||     :..|.:.|.
  Rat   278 PPGPFEVDAE-GRIHVTMELDREAQAE----YQLQVRAQN-SRGEDYAEPL-----ELQVVVMDE 331

  Fly   352 NDSPPVFNHKEYSVSLLENTLPGTPLALDMSVSDADV-------------------GINSKFALR 397
            ||:.||.:..:.::|:.|.:.|||.:| .:|..|.|.                   |..:| |..
  Rat   332 NDNAPVCSPHDPTISIPELSPPGTEVA-RLSAEDLDAPGSPNSHIVYQLLSPEPEQGAENK-AFE 394

  Fly   398 LDDVSGVFDVEPKLVTGYSQVNIRVANGTLDYENPNQRKFIVLVVAEETDTNPRLSSTATITVSV 462
            :|..||                 .|..||... :..|...:.::..:...:...||||..:.|.:
  Rat   395 IDSTSG-----------------SVTLGTAPL-HAGQNILLQVLAVDLAGSEGGLSSTCEVAVMI 441

  Fly   463 LDANDNKPVF-EQESYSASVSEAALPGQYIATITARDVDSGSYGDSGIRYSLSGTGAELFHVNEQ 526
            .|.|::.|.| ..:....|:.|...||..:||:.|.|.|...      .:.|.....|   ..:.
  Rat   442 TDINNHAPEFINSQIGPISLPEDVKPGSLVATLMATDADLEP------AFRLMDFAIE---EGDP 497

  Fly   527 TGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAP 591
            ||:..|:...|:.....|.|::|:.:|                         .|..:..::.:..
  Rat   498 TGIFDLSRESDSNHVQLRLRKNLSYEE-------------------------APDHKVVVVVRNV 537

  Fly   592 EEQASSVPLPAPVPHAAPSGVPAATAN-----DDKAPQTCLDYESETT----------YFLSYKA 641
            ||      |..|.|.      |||||.     :...|...||.||..|          ..|:.:.
  Rat   538 EE------LVGPGPG------PAATATVTILVERVIPPLKLDQESYETSIPVSTPAGSLLLTIQP 590

  Fly   642 TDDNGRGSASVVSLRISVTDANDSPP-VC----ESPLYRASVDEGAVVFDS-PLIVKARDAD 697
            :|...|      :||.|:  .|||.. :|    ...:|.|...:||...|: .::|:|:|.|
  Rat   591 SDPMNR------TLRFSL--VNDSEGWLCIKEVSGEVYTAQSLQGAQPGDTYTVLVEAQDTD 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	26/77 (34%)
		Cadherin_repeat	136..240	CDD:206637	22/109 (20%)
		Cadherin_repeat	248..353	CDD:206637	27/117 (23%)
		Cadherin_repeat	362..468	CDD:206637	26/124 (21%)
		Cadherin_repeat	476..>533	CDD:206637	13/56 (23%)
		E_set	<627..667	CDD:298831	14/49 (29%)
		CA	692..772	CDD:214520	3/6 (50%)
		Cadherin_repeat	778..873	CDD:206637
		Cadherin_repeat	882..994	CDD:206637
		Cadherin_repeat	1015..1099	CDD:206637
		Cadherin_repeat	1108..1207	CDD:206637
		Cadherin_repeat	1215..1314	CDD:206637
		Cadherin_repeat	1327..1427	CDD:206637
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
Cdh16	NP_001012055.1	CA	268..336	CDD:214520	24/84 (29%)
		Cadherin_repeat	344..447	CDD:206637	26/122 (21%)
		Cadherin_repeat	459..560	CDD:206637	30/146 (21%)
		Cadherin_repeat	570..657	CDD:206637	21/83 (25%)
		CA	55..126	CDD:214520	26/78 (33%)
		Cadherin_repeat	132..236	CDD:206637	26/125 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000