DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad87A and Pcdh1

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	XP_038953281.1	Gene:	Pcdh1 / 307481	RGDID:	1308490	Length:	1231	Species:	Rattus norvegicus

Alignment Length:	858	Identity:	221/858 - (25%)
Similarity:	344/858 - (40%)	Gaps:	163/858 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 PTVQYT--LITQAPEEQ---------ASSVPLP---------APVPHAAPSG-----VPAATAND 619
            |:..:|  ::.:.||||         |:...||         ...|:....|     ....|:.|
  Rat    45 PSASHTTQVVYKVPEEQPPNTLIGSLAADYGLPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSID 109

  Fly   620 DKAPQTCLDYESETTYFLSYKA--TDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDEGA 682
            .:..:.|.:..|.:...|.::.  ||....||..::..:|.|.|.||:.|...||:...::.|..
  Rat   110 REGLRECQNQISGSPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENT 174

  Fly   683 VV---FDSPLIVKARDADTMSRISYRIRGSEQVESIF------DIDRETGQIIIRPNATLDVTNL 738
            .:   |..||... |||......||.::...:.:.:|      |.:.:..|:|:..|  ||....
  Rat   175 NIGSLFPIPLATD-RDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGN--LDRERW 236

  Fly   739 NSDQLIFAVE-------ANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERV 796
            :|..|...|:       |:..|      :.:||.|.|::.|.||:.:|.|.:.|||.||.||.:|
  Rat   237 DSYDLTIKVQDGGSPPRASSAL------LRVTVLDTNDNAPKFERPTYEAELSENSPIGHSVIQV 295

  Fly   797 HATDLDTGKNAELRYRIQQG--------SFDDFGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQ 853
            .|.|.|.|.|||:.|...|.        ..|     ..||.:.|...:|.:..:|.:..:.|.|:
  Rat   296 KANDSDQGANAEIDYTFHQAPEVVRRLLRLD-----RNTGLITVQGPVDREDLSTLRFSVLAKDR 355

  Fly   854 GTPSLTGTATLTINVQNSNDKDPYF----VPATQHAEVRADAPPGQLVYTLIAL----DPDVANH 910
            |....:..|.:.:.|::.||..|..    :....|.:..|:........|.:||    |.|...:
  Rat   356 GANPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGEN 420

  Fly   911 NALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSVNKQLDRNLFAVMRINVLVTDSTAP 975
            .|:......|:....::..|... |..|:||       :.....||........|.::..||..|
  Rat   421 AAVTCVVAGDVPFQLRQASETGS-DSKKKYF-------LQTTTPLDYEKVKDYTIEIVAVDSGNP 477

  Fly   976 NVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDSSIG---- 1036
            .:.....|. :|::|||.|.|.|.      |...::...|....|.|:..:.|:|.||...
  Rat   478 PLSSTNSLR-VQVVDVNDNAPVFT------QSITEVAFPENNKPGEVVAEVTASDADSGSNAELV 535

  Fly  1037 ---EFNISDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLND 1098
               |...:....|.|:..:|.:.....||.|.....:.:|..:|.|.|:|..||.|:|::::.||
  Rat   536 YSLEPEPAAQGLFTISPENGEVRVKTSLDREQRDSYELKVVAADRGSPSLQGTATVLVNVLDCND 600

  Fly  1099 NDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYFSIDAYTGNVMVAN 1163
            |||||..|.|.|:|.||.|..:..|.|...|||.|....:..: :.::|..|.|...||.::  :
  Rat   601 NDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENARVQLS-VEQDNGDFVIQNGTGTIL--S 662

  Fly  1164 SSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQ- 1227
            |...||||....|..:.|.|  .....:||...:.||:||.|||||..       |...|.:::
  Rat   663 SLSFDREQQSTYTFQLKAVD--GGVPPRSAYVGVTINVLDENDNAPFI-------TAPSNTSHRL 718

  Fly  1228 --PPAAL----LQVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLSGK-HGAYEL 1285
              |...|    .||.|.|.|.|:..::.|.|..||..|||::.:.||.:...:.:..: ||.:.|
  Rat   719 LTPQTRLGETVSQVTAEDIDSGINAELTYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRL 783

  Fly  1286 TISARDTQGSGTMESTTKAIITVLRVNRHKPE---------FVIPALSNAT-------------- 1327
            .:...|                     |.||.         :|...|:|.|
  Rat   784 VVKVSD---------------------RGKPPRYGTALVHLYVNETLANRTLLETLLVHSLDTPL 827

  Fly  1328 -IEIPGDIVQPDY 1339
             |:|.||   |:|
  Rat   828 DIDIAGD---PEY 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		E_set	<627..667	CDD:298831	11/41 (27%)
		CA	692..772	CDD:214520	21/92 (23%)
		Cadherin_repeat	778..873	CDD:206637	30/102 (29%)
		Cadherin_repeat	882..994	CDD:206637	25/115 (22%)
		Cadherin_repeat	1015..1099	CDD:206637	24/90 (27%)
		Cadherin_repeat	1108..1207	CDD:206637	32/98 (33%)
		Cadherin_repeat	1215..1314	CDD:206637	23/106 (22%)
		Cadherin_repeat	1327..1427	CDD:206637	7/28 (25%)
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
Pcdh1	XP_038953281.1	Cadherin_2	52..131	CDD:400525	14/78 (18%)
		Cadherin_repeat	165..269	CDD:206637	25/112 (22%)
		Cadherin_repeat	277..376	CDD:206637	31/103 (30%)
		Cadherin_repeat	395..495	CDD:206637	24/108 (22%)
		Cadherin_repeat	505..601	CDD:206637	24/95 (25%)
		Cadherin_repeat	610..704	CDD:206637	32/98 (33%)
		Cadherin_repeat	723..805	CDD:206637	23/102 (23%)
		Protocadherin	808..1022	CDD:400603	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000