DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and Pcdh20

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_001100750.1	Gene:	Pcdh20 / 306081	RGDID:	1306297	Length:	952	Species:	Rattus norvegicus

Alignment Length:	950	Identity:	231/950 - (24%)
Similarity:	387/950 - (40%)	Gaps:	142/950 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 GHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPSGVPAATANDDKAPQTC 626
            |||...|...:.|.:   |.|....:...|....:|......:.::...|:||.......|....
  Rat    29 GHLHRPSSRTSHRNL---PHVVLLFLFVGPFNCLASYSRATELLYSLNEGLPAGVLIGSLAEDLR 90

  Fly   627 LDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIV 691
            |             ....:||.|..:  |....|.|..:||:..| |....:....|..|:
  Rat    91 L-------------LPRASGRQSQQL--LHPERTAAEGNPPLSFS-LASGGLSGQYVTLDN---- 135

  Fly   692 KARDADTMSRISYRIRGSEQVESIFDIDRET------------GQIIIRPNATLDVTNLNSDQLI 744
                           |..|...|..:||||.            |...|..:.:.|...|..|.|:
  Rat   136 ---------------RSGELHTSAQEIDREALCLDGGGGAAWGGSTSIASSPSSDSCLLLLDVLV 185

  Fly   745 FAVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVH-ATDLDTGKNAE 808
            ...|     :.....|.|.:||:|::.|.|.....|..|.|||.:.|.:...| |.|.|.|.|..
  Rat   186 LPQE-----YFRFVKVKIAIRDINDNAPQFPISEISVWVPENSPVNTRLAIEHPAVDPDVGINGV 245

  Fly   809 LRYRI--QQGSF------DDFGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLT 865
            ..||:  ..|.|      ::.|  |.|..:.|...||.:.::.|...|.|.|.|:|.|.|:||||
  Rat   246 QTYRLLDYHGMFTLDVEENENG--ERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLT 308

  Fly   866 INVQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKE 930
            |.:.:.||..|.|:.:..:..|..:|..|..|.|:.|:|.|:..:..:.::.:.   .:.:|.||
  Rat   309 IGISDINDNCPLFIDSQINVTVYGNATVGTPVTTVQAVDRDLGTNAQITYSYSQ---KVPQESKE 370

  Fly   931 LPHYDQFKEYFKISRNGKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGRGLL------IIQII 989
            |.|.|:.        .|.|.::.::..|:....::.:|.         .|.|.:      ::.||
  Rat   371 LFHLDEV--------TGVVKLSSKIGGNVLQTHKLTILA---------NGPGCIPAVITALVSII 418

  Fly   990 DVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDSSI---------GEFNIS---- 1041
            .|...||.....:...:....:.:.|.:||.|.:......|.:...         |.|.::
  Rat   419 KVVFRPPEIVPRYIANEMDGVVYLKELEPVNTPIAFFTIRDPEGKYKINCYLEGEGPFRLAPYKP 483

  Fly  1042 -DNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQ 1105
             :|:|        ::.|...:|||:  :..:::.|.............:.|.:::.|||.|.|.|
  Rat   484 YNNEY--------LLETTKPMDYEL--QPFYEIAVVAWNSEGFHDKRIIKVQLLDDNDNAPVFLQ 538

  Fly  1106 SDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYFSIDAYTGNVMVANSSILDRE 1170
            ......:.||:.......|:.|.|.|.|..|.::|.|..:...|||:|:.||.:.|  |:.||||
  Rat   539 PLIELTIEENNAPNAFLTKLYATDADSGEMGRVSYFLGPDAPSYFSLDSVTGILTV--STQLDRE 601

  Fly  1171 QIKELTLSVVAQD--KAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPAALL 1233
            :.::...:|.|.|  |.|    :.:.||:.:.:||.|||:|.|....::..|.||........::
  Rat   602 EKEKYRYTVRAVDCGKPP----RESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVI 662

  Fly  1234 QVQAIDQDEGLYGDVRYIITAGNEMGLFKLDAQSGIVYPAQSLS-GKHGAYELTISARDTQGSGT 1297
            .|  .|.|.|..|.|  .::..|:..:|.:|...|::....||. .:..:|.|.:.|.| .|...
  Rat   663 SV--TDADAGRNGWV--ALSVMNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVD-GGEPA 722

  Fly  1298 MESTTKAIITVLRVNRHKPEFVIPALSNAT--IEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYH 1360
            :.||||..|.:|.:|.:.|..:.|. ||.:  :.:|..:  |...:..|.|:|.||..|..::|
  Rat   723 LSSTTKITILLLDINDNPPLVLFPQ-SNMSYLLVLPSTL--PGSPVTEVYAVDKDTGMNAVIAY- 783

  Fly  1361 LQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAGNP-PFESLRLLSVSIVD- 1423
             .:..|...:...|:||..||.:..:..|.:.:...:.:::...|.|.| |..|..::::.:.|
  Rat   784 -SIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDT 847

  Fly  1424 -ANENRPEFPDASNPYKVSINENSGR-DVKIGHIQAASRS 1461
             :||:..|......| :::|.|...: .:|..|.:..|.|
  Rat   848 VSNESYIESLLRKEP-EINIEEKEPQISIKPTHRKVESMS 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		E_set	<627..667	CDD:298831	7/39 (18%)
		CA	692..772	CDD:214520	19/91 (21%)
		Cadherin_repeat	778..873	CDD:206637	35/103 (34%)
		Cadherin_repeat	882..994	CDD:206637	23/117 (20%)
		Cadherin_repeat	1015..1099	CDD:206637	16/97 (16%)
		Cadherin_repeat	1108..1207	CDD:206637	32/100 (32%)
		Cadherin_repeat	1215..1314	CDD:206637	27/99 (27%)
		Cadherin_repeat	1327..1427	CDD:206637	23/104 (22%)
		Cadherin_repeat	1437..1549	CDD:206637	6/25 (24%)
		Cadherin_repeat	1557..1662	CDD:206637
Pcdh20	NP_001100750.1	E_set	70..>153	CDD:298831	24/117 (21%)
		Cadherin_repeat	214..317	CDD:206637	36/104 (35%)
		Cadherin_repeat	325..417	CDD:206637	20/111 (18%)
		E_set	439..>510	CDD:298831	14/80 (18%)
		E_set	<490..534	CDD:298831	9/45 (20%)
		Cadherin_repeat	541..636	CDD:206637	32/100 (32%)
		Cadherin_repeat	645..739	CDD:206637	27/98 (28%)
		Cadherin_repeat	755..846	CDD:206637	21/94 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000