DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and PCDHB1

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_037472.2	Gene:	PCDHB1 / 29930	HGNCID:	8680	Length:	818	Species:	Homo sapiens

Alignment Length:	788	Identity:	186/788 - (23%)
Similarity:	302/788 - (38%)	Gaps:	200/788 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 SEQVESIFDIDRETGQIIIRPNATLDVTNL--NSDQLI--FAVEANDGL--FTAHCGVNITVRDV 767
            ||..:..|.:.|:||.:.::..  ||..:|  .:|..:  |.|...:.|  |.|    .:.|.|:
Human    68 SEGNKMHFRLHRKTGDLFVKEK--LDRESLCGKADPCVLHFEVVLVEPLQSFRA----EVRVFDI 126

  Fly   768 NNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGS-------FDDFGIVE 825
            |::.|.|..:.....:.|::.:|:......|.|||.|.|....|.:....       |...|  .
Human   127 NDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHTRFCSHG--P 189

  Fly   826 TTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRAD 890
            ...|:.:::.||.:.:....|.|.|.|.|:|..:|||.:.:.|.:.||..|.|......|:|..:
Human   190 KYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSEN 254

  Fly   891 APPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKIS-RNGKVSVNKQ 954
            :|.|.||.|:.|:|.|...:.|:.::...:..||.|.             |:|. :||:|.:...
Human   255 SPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKT-------------FQIDPQNGEVRLRGP 306

  Fly   955 LDRNLFAVMRINVLVTDSTAPNVQQGRGL-----LIIQIIDVNKNPPRFNAPWSVEQPQIKLQMV 1014
            ||........|::..||        |.||     ::::::|||.|||..... ||..|     :.
Human   307 LDFEAIETYDIDIQATD--------GGGLSAHSKVLVEVVDVNDNPPEVMVS-SVSSP-----LP 357

  Fly  1015 EEQPVGTVLTTLQANDEDSSIG---EFNISDNDYFAINQTSGMIYTIA---RLDYEVVKEVKFQV 1073
            |:.|..||:......|.|..:|   ...:.::..|.|..|.|..|::.   .||.|.|......:
Human   358 EDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITI 422

  Fly  1074 TVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEI 1138
            ...|||.|:|:|...:.|.|.::|||.|.|.:..|...|.||:......|||.|.|.|:|...:|
Human   423 VAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQI 487

  Fly  1139 TYTLIGENNKYFSIDAY----TGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHI 1199
            ||:|:...|...|:.||    :||..:.....:|.|.|::....|.|.|  ...:..|:..|:.:
Human   488 TYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATD--GGFLSLSSQVTVRV 550

  Fly  1200 NILDVNDNAPVFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKLD 1264
            .:||.|||.|:
Human   551 VVLDDNDNRPM------------------------------------------------------ 561

  Fly  1265 AQSGIVYPAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIE 1329
                |:||.|                    :||:....                ::|..:.|
Human   562 ----ILYPLQ--------------------NGTLPCND----------------LVPRSAEA--- 583

  Fly  1330 IPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNR 1394
                    .||:..|.|:|.|:.:|..:||||    ......|.|.:....||:....|::.::.
Human   584 --------GYLVTKVVAVDGDSGQNSWLSYHL----LKATDLGLFSVQRQNGEIHTLRQISERDP 636

  Fly  1395 ANYDIILVARDAGNPPFESLRLLSVSIVDANENRPEFPDASNPYKVSINENSGRDVKIGHIQAAS 1459
            ....:|::.:|.|.|...:...|::.:||.         .|.||                :|...
Human   637 MMQKLIILVQDHGQPALSTTVSLNILLVDG---------FSEPY----------------LQFQD 676

  Fly  1460 RSKHNRDI 1467
            .:||:|.:
Human   677 PTKHSRKV 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		E_set	<627..667	CDD:298831
		CA	692..772	CDD:214520	18/68 (26%)
		Cadherin_repeat	778..873	CDD:206637	24/101 (24%)
		Cadherin_repeat	882..994	CDD:206637	30/117 (26%)
		Cadherin_repeat	1015..1099	CDD:206637	25/89 (28%)
		Cadherin_repeat	1108..1207	CDD:206637	32/102 (31%)
		Cadherin_repeat	1215..1314	CDD:206637	6/98 (6%)
		Cadherin_repeat	1327..1427	CDD:206637	23/99 (23%)
		Cadherin_repeat	1437..1549	CDD:206637	6/31 (19%)
		Cadherin_repeat	1557..1662	CDD:206637
PCDHB1	NP_037472.2	Cadherin_2	30..110	CDD:311943	12/43 (28%)
		Cadherin_repeat	140..238	CDD:206637	25/99 (25%)
		Cadherin_repeat	246..343	CDD:206637	30/117 (26%)
		Cadherin_repeat	356..448	CDD:206637	25/91 (27%)
		Cadherin_repeat	456..558	CDD:206637	32/103 (31%)
		Cadherin_repeat	577..665	CDD:206637	23/102 (23%)
		Cadherin_C_2	688..772	CDD:318652
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000