DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad87A and Cdhr2

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	XP_214434.4	Gene:	Cdhr2 / 291002	RGDID:	1560576	Length:	1310	Species:	Rattus norvegicus

Alignment Length:	1631	Identity:	370/1631 - (22%)
Similarity:	609/1631 - (37%)	Gaps:	457/1631 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LGLLMICLGLTLAKGETNLPPVFTQTLNNIILYENVTVGTVVFRLEAYDPEGSPVTYGAIG--AD 67
            |.||.:.|...:.....|..|||...:..::|.|::.||.|||.|.|.||:|..:|||..|  |:
  Rat     4 LWLLCVLLPTFMVSVTANSLPVFESNMTLVLLPEDLPVGAVVFWLVATDPDGDQLTYGISGLHAN 68

  Fly    68 HFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDNPPEF 132
            :|||...:|.:.|:..||.|...:.:..:|:.|..:.:...|...:||        |.|||.|.|
  Rat    69 YFSVTSNTGEVKLVSSLDFETLPSFRITISVNDGHNVQVTKEMQVIVE--------DRNDNAPVF 125

  Fly   133 QNTPYEADVNEDAAVGTTIFDKITVKDRDI----VGESLDLKCLPQQQSPEACRKFRLHIIKRDA 193
            .||.:...:.|...||:.:| .:..:|:|.    :.|....|.:|...:.:..  ||:
  Rat   126 LNTEFSTSIKETLPVGSVVF-SVLAEDKDTGSSGLVEYFIEKVIPSTDNSKDL--FRI------- 180

  Fly   194 TILEAAVVLNDTLNYNQRMV-YHFQIEATDGPHKTQTTFEAR----------VKDVQDKPPVF-Q 246
             ::..::||||||:||.:.. |..:::|.|.......|...:          |.|..|..|.| :
  Rat   181 -LVNGSIVLNDTLSYNNKSAFYQLELKACDSGGLLNNTLVTQCSQPVFVSISVIDEPDLDPQFVR 244

  Fly   247 GSLSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDL--RTNPNDYFLLDAQTGELRTAKPLDRE 309
            ...|..:.||:.:.|.||.|.|.|.|.|....:.|::  .|.|. :|.:: :.|.:....|||||
  Rat   245 EFYSASVSEDATLGTSVLAVEAVDSDKGVNYNVTYNITNSTRPG-WFCIE-KDGVITVCGPLDRE 307

  Fly   310 ALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSLLENTL-- 372
            .|......:.:.:.|.|....:...:...|..  .|:.:.||||..|.|    |:.||...|.
  Rat   308 QLLLDNEEVQIQVTATEEKPNIYQQEAKVSTW--VTIKVTDVNDHKPEF----YNCSLQNCTFSP 366

  Fly   373 --------------PGTPLALD---MSVSDADVGINSKFALRLDDVSG-VFDVEPKLVTGYSQVN 419
                          ....:::|   |...|.|.|.|..|.|.|:.... .|:|.|:.......|.
  Rat   367 QEAQDNFTGYVDEHASARISIDGLTMVAYDPDQGANGTFLLSLNGTDAEAFNVSPERAAVSVSVQ 431

  Fly   420 IRVANGTL-DYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSE 483
            :.|.|..: |||...:.:  |.|||  ||:.....|.||:|:.:.:.||::|||.:..|..:|.|
  Rat   432 VVVKNSEMVDYEKKTEMQ--VQVVA--TDSVSGNYSVATVTIHLRNINDHRPVFSKSLYELTVPE 492

  Fly   484 AALPGQYIAT--ITARDVDSGSYGDSGIRYS-LSGTGAELFHVNEQTGVISLANCHDNGESNRRE 545
            .: |..::.|  |.|.|:|...:|.  |.|| |.|.|.:||.|..::|.:::.|
  Rat   493 NS-PTGFLVTDSIEATDLDGDEWGP--ITYSLLPGAGEDLFEVEPKSGNVTVKN----------- 543

  Fly   546 RRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPS 610

  Rat   544 ----------------------------------------------------------------- 543

  Fly   611 GVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYR 675
                         .|.||.|.:..|:|:.:|||  |...::...|:|::.|.||:|||.... |.
  Rat   544 -------------GTLLDREKQAMYYLTMQATD--GGNQSTTTMLQITLLDVNDNPPVVRGS-YN 592

  Fly   676 ASV--DEGAVVFDSPLIVKARDAD----TMSRISYRIRGSEQVESIFDIDRETGQIIIRPNATLD 734
            ..|  ::|    |..:.::|.|.|    ..||:.:.:......:: |.||.:||  ::|....||
  Rat   593 IFVPEEDG----DVSVTIQAYDDDQPGTNNSRLLFSLLPGSYSQN-FSIDPDTG--LLRNLEPLD 650

  Fly   735 VTNLN---SDQLIFAVEANDGLFTAHCG---------VNITVRDVNNHVPNFEQQSYSAVVEENS 787
            ...::   ..:::..|...|      ||         |.|||.|:|:::|.|.|.||...|.|..
  Rat   651 REAIDPALEGRIVLTVHVAD------CGEPSLSTDVNVTITVEDINDNLPIFNQSSYEFFVMERV 709

  Fly   788 EIGTSVERVHATDLD-TGKNAELRYRIQQGSFDDF---GIVETTG------EVFVSRKLDFDRRN 842
            . |..|..|.|.|.| |..|..:.:.:.....::|   .||...|      .:.....||::.:.
  Rat   710 P-GALVGTVKAWDADQTAANNRISFSLSGTGANNFILQSIVLALGWAEGHLWLLPDVSLDYETQK 773

  Fly   843 TYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDV 907
            .:.|.:.|.:.|...|..||.:|:.|.:.||:.|                      ||     |.
  Rat   774 LFNLTVSAENPGPQGLESTANITVVVVDVNDEPP----------------------TL-----DA 811

  Fly   908 ANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVS--VNKQLDRNLFAVMRINVLVT 970
            .:..::..|         :.|.|               :|:|:  :.:.:|.|
  Rat   812 VSLQSISVA---------ENGSE---------------HGQVAQVIAQDVDTN------------ 840

  Fly   971 DSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDSSI 1035
                       .||.|:::|                               ||.|....|..|..
  Rat   841 -----------ALLRIELVD-------------------------------VLCTKAGVDVGSVC 863

  Fly  1036 -GEFNISDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDN 1099
             |.|::..|....|||:..:.|.:..|   |...|:.|...:|.|..|.::...::::|.:.|||
  Rat   864 HGWFSVDTNGSVYINQSEAIDYEVCHL---VTLVVRAQDLATDLGFDAYSSNGSLLINIKDKNDN 925

  Fly  1100 DPKFSQSDYYFNVTEN--SPRGTVAGKVEAHDGDVGVFGEITYTLI--------GENN--KYF-- 1150
            .|.|..::..|.:...  .|...|| .|:|.|.|....|.|.::::        |..|  :.|
  Rat   926 TPYFLPNNQTFVIIPELVLPNQQVA-SVQARDEDSEDNGIIKFSILKADFVPKDGATNPVQVFRI 989

  Fly  1151 --SIDA--YTGNV-MVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPV 1210
              |::|  |||:: :|.|   ||........::|.|||: ||......|.|. :|:..|:.:..|
  Rat   990 SQSVEAGLYTGSIELVTN---LDSTLQGTYQVTVQAQDQ-PAMDPALETQTT-LNLFTVDQSYRV 1049

  Fly  1211 FTRDVYNSTVAENAA---YQPPAALLQ----------VQAIDQ----DEGLYGDVRYIITAGNEM 1258
               .:..||..|:..   .:..|||:|          :|.||.    ....|.|..::.:.|:.:
  Rat  1050 ---RLQFSTSREDVGANMEEIKAALIQATRTSVYVVTIQNIDSMARARVNSYMDAYFVFSNGSAL 1111

  Fly  1259 GLFKLDA-------------QSGIVYPAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLR 1310
            .|.:|:.             |.|:|               .:|:::||.....:..|..||.:
  Rat  1112 TLTELNVMIRKDQDALRQLLQLGLV---------------VVSSQETQEFNQTQLLTNVIIGL-- 1159

  Fly  1311 VNRHKPEFVIPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVN-NRNEQQTGEF 1374
                    |:..:....|.|..        |:..|.           |||.::. .:..::..:.
  Rat  1160 --------VVSLVLVLVIMITA--------LVCFRK-----------SYHRKLRAMKAGKEARKT 1197

  Fly  1375 KIDEVTGELRAK-TQLNRKNRANYDIILVARDAG-------NPPFESLRLLSVSIVDANENRPEF 1431
            .|:.:|...... |.:...:|||..:.|..:|.|       :..:.||..|..:.||.:.:..||
  Rat  1198 PIETMTPAAAIPGTNVYNTDRANPMLDLPTKDLGLECHSSSDLDYHSLNSLDENSVDLDTDSKEF 1262

  Fly  1432 PDASNPYKVSINENSGRDVKIGHIQAASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLD 1496
            .....|:....:::......:....|.:..:..|::                     .:||..||
  Rat  1263 KRKDLPHNPPESDSEPLTAALSGRSAGTSGQQQREL---------------------SFTNPGLD 1306

  Fly  1497 REETDV 1502
              .||:
  Rat  1307 --TTDL 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	32/96 (33%)
		Cadherin_repeat	136..240	CDD:206637	25/118 (21%)
		Cadherin_repeat	248..353	CDD:206637	28/106 (26%)
		Cadherin_repeat	362..468	CDD:206637	33/126 (26%)
		Cadherin_repeat	476..>533	CDD:206637	20/59 (34%)
		E_set	<627..667	CDD:298831	14/39 (36%)
		CA	692..772	CDD:214520	23/95 (24%)
		Cadherin_repeat	778..873	CDD:206637	26/104 (25%)
		Cadherin_repeat	882..994	CDD:206637	14/113 (12%)
		Cadherin_repeat	1015..1099	CDD:206637	21/84 (25%)
		Cadherin_repeat	1108..1207	CDD:206637	32/117 (27%)
		Cadherin_repeat	1215..1314	CDD:206637	24/128 (19%)
		Cadherin_repeat	1327..1427	CDD:206637	21/108 (19%)
		Cadherin_repeat	1437..1549	CDD:206637	9/66 (14%)
		Cadherin_repeat	1557..1662	CDD:206637
Cdhr2	XP_214434.4	Cadherin_repeat	33..121	CDD:206637	32/95 (34%)
		Cadherin_repeat	129..237	CDD:206637	25/118 (21%)
		Cadherin_repeat	247..350	CDD:206637	29/106 (27%)
		Cadherin_repeat	373..477	CDD:206637	29/107 (27%)
		Cadherin_repeat	486..583	CDD:206637	35/190 (18%)
		Cadherin_repeat	590..692	CDD:206637	27/115 (23%)
		Cadherin_repeat	700..804	CDD:206637	26/104 (25%)
		Cadherin_repeat	816..925	CDD:206637	32/189 (17%)
		Cadherin_repeat	936..1044	CDD:206637	31/113 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24028
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010