Protein Alignment Cad87A and Pcdh19

DIOPT Version :10

• Sequence 1: NP_731649.2
• Gene: Cad87A / 41441
• FlyBaseID: FBgn0037963
• Length: 1975
• Species: Drosophila melanogaster
• Sequence 2: NP_001098715.1
• Gene: Pcdh19 / 279653
• MGIID: 2685563
• Length: 1145
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 259/1147 - (22%)
• Similarity: 420/1147 - (36%)
• Gaps: 327/1147 - (28%)

  Fly   649 SASVVSLRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVK-ARDA----DTMSRISYRIRG 708
            :|::::|:.||.:..           ||    |.|:.:   :.| ||:|    |.....::|: .
Mouse    19 AAALINLKYSVEEEQ-----------RA----GTVIAN---VAKDAREAGFALDPRQASAFRV-V 64

  Fly   709 SEQVESIFDIDRETGQIIIRPNATLDVTNLNSDQLIFAVEANDGLFTAHCGVNITVRDVNNHVPN 773
            |.....:.||:..:|.::.:.....|:....|.:.|.::|........ |.:.:.::|:|::.|:
Mouse    65 SNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEI-CVIKVEIKDLNDNAPS 128

  Fly   774 FEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDDFGI-VETTG------EVF 831
            |........:.|.:..||.:....|.|.|:|......|.:.....  ||: ::|.|      |:.
Mouse   129 FPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNEL--FGLEIKTRGDGSRFAELV 191

  Fly   832 VSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQL 896
            |.:.||.:.::.|..:|.|.|.|.|...||..|:|.|.:|||.:|.|..:|....|..::||...
Mouse   192 VEKSLDRETQSHYSFRITALDGGDPPHMGTVGLSIKVTDSNDNNPVFGESTYSVSVPENSPPNTP 256

  Fly   897 VYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSVNKQLDRNLFA 961
            |..|.|.|||                    ||                .||:|..
Mouse   257 VIRLNASDPD--------------------EG----------------TNGQVVY---------- 275

  Fly   962 VMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTL 1026
                                                                             
Mouse   276 ----------------------------------------------------------------- 275

  Fly  1027 QANDEDSSIGEFNISDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVV 1091
                  |..|..|....:.|.|:..||::.....||||.....:..|...|.|..::.|...|.|
Mouse   276 ------SFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTV 334

  Fly  1092 DIINLNDNDP---KFSQSDYYFNVTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYFSID 1153
            .:::.|||.|   ..|.:.....|:|::|.|.|...|...|.|.|:.|.:...|:|  |..|.:.
Mouse   335 SVLDTNDNPPIINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLG--NVPFRLQ 397

  Fly  1154 AYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYNS 1218
            .|.....:.....|||||..:..|::.|:|.....:|.:.:.|:.|.  |.|||.|.|::..|..
Mouse   398 EYESFSTILVDGRLDREQHDQYNLTIQARDSGVPMLQSAKSFTVRIT--DENDNHPHFSKPYYQV 460

  Fly  1219 TVAENAAYQPPAALLQVQAIDQDEGLYGDVRYIITAG--NEMGLF---KLDAQSGIVYPAQSLSG 1278
            .|.||..  |.|.||.|.|.|.|.||.|.|.|.|...  .:|.:|   .::..||.:|..:|.:.
Mouse   461 IVQENNT--PGAYLLSVSARDPDMGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNH 523

  Fly  1279 KH-GAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIE--IP-----GDIV 1335
            :. .|:|..:.|:| .|..:::|.....:.:|.||.:.|....|.|.|.|.|  ||     |
Mouse   524 EQTKAFEFKVLAKD-GGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIG--- 584

  Fly  1336 QPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNRANYDII 1400
               ||:..|:|.|.|..|||:|:|.:...:|     |.|:||:|.||:|.....|..::.:|::|
Mouse   585 ---YLVTVVKADDYDEGENGRVTYDMTEGDR-----GFFEIDQVNGEVRTTRTFNENSKPSYELI 641

  Fly  1401 LVARDAGNPPFESLRLLSVSI---VDANENRPEFPDASNPYKVSINENSGRDVKIGHIQAASRSK 1462
            :||.|.|.....:..|:.:.:   :||.|:                        :|.:
Mouse   642 VVAHDHGKTSLSASALVLIYLSPALDAQES------------------------MGSV------- 675

  Fly  1463 HNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILASIKADLHISEEERASFSI 1527
             |..:.:.:.||:..|..:|                      ..|..:||.       :|.:..|
Mouse   676 -NLSLIFIIALGSIAGILFV----------------------TMIFVAIKC-------KRDNKEI 710

  Fly  1528 KTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNANAKMGAAITLVNATDADQGKNAKIEFMI 1592
            :|.|..|.   :.||.|     ...|.|       ..|:|....|: |:....:|.|.|:.:..:
Mouse   711 RTYNCSNC---LTITCL-----LGCFIK-------GQNSKCLHCIS-VSPNSEEQDKKAEEKVSL 759

  Fly  1593 VASNL--YKFGATKSTGSIVPSPFAISQDGRISANTIMAEYNQDRFELEIVARELEQPQ------ 1649
            ....:  |.:|..|.:          |:..:||.|           ::.:|.|::|:..
Mouse   760 RGKRIAEYSYGHQKKS----------SKKKKISKN-----------DIRLVPRDVEETDKMNVVS 803

  Fly  1650 -SSASTKVNIWVFDGTQLVRVILSRPPEEVYQEQEEIIAELRNATQHRIIVDEIRFHLDSIGRIR 1713
             ||.::.:|  .||..|....:..|..|..:...|.  ...||.|...|
Mouse   804 CSSLTSSLN--YFDYHQQTLPLGCRRSESTFLNVEN--QNTRNTTASHI---------------- 848

  Fly  1714 MDWCDLYFHAVDPQTQQIAPVDEILKDI----DRNYDYLKDY 1751
                  |.|:.:.|..|  ..|.|:..:    ..||.:..:|
Mouse   849 ------YHHSFNSQGPQ--QPDLIINGVPLPETENYSFDSNY 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637
		Cadherin_repeat	136..240	CDD:206637
		Cadherin_repeat	248..353	CDD:206637
		Cadherin_repeat	362..468	CDD:206637
		Cadherin_repeat	476..>533	CDD:206637
		CA_like	<627..667	CDD:481204	4/17 (24%)
		CA	692..772	CDD:214520	17/84 (20%)
		Cadherin_repeat	778..873	CDD:206637	28/101 (28%)
		Cadherin_repeat	882..994	CDD:206637	15/111 (14%)
		Cadherin_repeat	1015..1099	CDD:206637	18/83 (22%)
		Cadherin_repeat	1108..1207	CDD:206637	28/98 (29%)
		Cadherin_repeat	1215..1314	CDD:206637	33/104 (32%)
		Cadherin_repeat	1327..1427	CDD:206637	35/109 (32%)
		Cadherin_repeat	1437..1549	CDD:206637	17/111 (15%)
		Cadherin_repeat	1557..1662	CDD:206637	20/113 (18%)
Pcdh19	NP_001098715.1	Cadherin_2	27..106	CDD:462413	20/97 (21%)
		Cadherin_repeat	133..234	CDD:206637	29/102 (28%)
		Cadherin_repeat	242..342	CDD:206637	33/216 (15%)
		Cadherin_repeat	356..449	CDD:206637	28/96 (29%)
		Cadherin_repeat	458..559	CDD:206637	33/103 (32%)
		Cadherin_repeat	574..662	CDD:206637	32/98 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..921
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1094..1145