DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad87A and Cdhr2

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_001028536.2	Gene:	Cdhr2 / 268663	MGIID:	2687323	Length:	1308	Species:	Mus musculus

Alignment Length:	1544	Identity:	370/1544 - (23%)
Similarity:	579/1544 - (37%)	Gaps:	404/1544 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LGLLMICLGLTLAKGETNLPPVFTQTLNNIILYENVTVGTVVFRLEAYDPEGSPVTYGAIG--AD 67
            |.||...|...:.....|.||.|...:..:.|.|::.||.|.|.|.|.|.:...:|||..|  |.
Mouse     4 LWLLCALLPAFMVSVTANSPPSFGVNMTLVTLPEDLPVGAVAFWLVATDSDNDHLTYGISGPNAS 68

  Fly    68 HFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDNPPEF 132
            :|||:..:|.:.|..|||.|.....|..:|..|.:         |:....:..|:.|.|||.|.|
Mouse    69 YFSVNANTGEVKLASPLDFETVPFFKITISTSDGL---------NIRTAEMQVIVEDRNDNIPVF 124

  Fly   133 QNTPYEADVNEDAAVGTTIFDKITVKDRDIVGESLDLKCLPQQQSPEACRKFRLHIIKRDATILE 197
            .||.:...:||...||:.:| .:..:|:| .|.:..::...::..|.......|.      .|||
Mouse   125 LNTEFSTSINETLPVGSVVF-SVLAEDKD-TGTAGLVQYFIEKVIPSTANSNNLF------RILE 181

  Fly   198 -AAVVLNDTLNYNQRMVYHFQIE--------ATDGPHKTQTT----FEARVKDVQDKPPVF-QGS 248
             .::||||||:||.:..: :|:|        ..|...|||.:    ....|.|..|..|.| :..
Mouse   182 NGSIVLNDTLSYNNKSAF-YQLELKACDSGGILDNKPKTQCSQPVFVSISVIDEPDLDPRFIREF 245

  Fly   249 LSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDLRTNPNDYFLLDAQTGELRTAKPLDREALED 313
            .|..:.||:.:.|.||||.|.|.|.|....:.|.:..:....:....:.|.:.....||||.|..
Mouse   246 YSASVAEDATLGTSVLTVEAVDSDKGINDIVTYSVSNSTRPGWFDIREDGVIFVNGSLDREQLLL 310

  Fly   314 STGIISLVIRARELVNGVPSDDPLTSATAKATVTIR--DVNDSPPVFNHKEYSVSLLENTLPGTP 376
            ....:.:.:.|.|....:...:    |.|...||||  ||||..|.|    |:.|     |||..
Mouse   311 ENEEVQIQVTATEKNLNIYGQE----AKASMWVTIRVTDVNDHKPEF----YNCS-----LPGCS 362

  Fly   377 LA------------------------LDMSVSDADVGINSKFALRLDDVSG-VFDVEPKLVTGYS 416
            .:                        |.|...|.|.|.|..|.|.|:.... .|:|.|:...|..
Mouse   363 FSPQEAQVNFIGYVDEHASARISIDGLTMVAYDPDQGDNGTFLLSLNGQDAEAFNVSPERAAGSV 427

  Fly   417 QVNIRVANGTL-DYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSAS 480
            .|.:.|.|..: |||  .:...:|.|||  ||:.....|.||:|:.:.:.||::|||.|..|..:
Mouse   428 SVQVVVRNSEMVDYE--KETVMVVEVVA--TDSVSNNYSVATVTIHLRNINDHRPVFSQSLYELT 488

  Fly   481 VSEAALPGQYIAT--ITARDVDSGSYGDSGIRYS-LSGTGAELFHVNEQTGVISLANCHDNGESN 542
            |.|.. |..|:.|  |.|.|:|...:|.  |.|| |.|.||:||.|...:|.:::.|
Mouse   489 VPEHC-PTGYLVTDKIQATDLDGDEWGP--ITYSLLPGNGADLFEVEPNSGNLTVKN-------- 542

  Fly   543 RRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHA 607

Mouse   543 ----------------------------------------------------------------- 542

  Fly   608 APSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESP 672
                            .|.||.|.:..|:|:.:|||  |...::..:|.|::.|.||:|||....
Mouse   543 ----------------GTLLDREKQAVYYLTLQATD--GGNQSTTTALEITLLDINDNPPVVRGS 589

  Fly   673 LYRASVDE--GAVVFDSPLIVKARDAD----TMSRISYRIRGSEQVESIFDIDRETGQIIIRPNA 731
             |...|.|  |.|    .:.::|.|.|    ..|.:.:.:... ...|.|.:|..||  ::|...
Mouse   590 -YNVFVPEENGNV----SVTIQAYDDDQPDTNNSLLVFSLLPG-PYSSNFSLDPNTG--LLRNLG 646

  Fly   732 TLDVTNLN---SDQLIFAVEANDGLFTAHCG---------VNITVRDVNNHVPNFEQQSYSAVVE 784
            .||...::   ..:::..|      ..|.||         |.|||.|:|:::|.| .|||...|.
Mouse   647 PLDREAIDPALEGRIVLTV------IVADCGEPSLSTNVNVTITVEDINDNLPVF-NQSYEFSVW 704

  Fly   785 ENSEIGTSVERVHATDLD-TGKNAELRYR---------IQQGSFDDFGIVETTGEVFVSRKLDFD 839
            |... |..|..|.|.|.| |..|..:.:.         |.||:..:.|..|.:..:....:||::
Mouse   705 ERVP-GAWVGTVKAWDADQTAANNRISFSLSGTGANNFILQGNVLEQGWAEGSLWLLPDVRLDYE 768

  Fly   840 RRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPAT-QHAEVRADAPPGQLVYTLIAL 903
            .:..:.|.:.|.:.|...|..||.:|:.|.:.||:.|....|: |...|..:......|..:||.
Mouse   769 TQKFFHLTVSAENPGPQGLDSTANVTVTVMDVNDEPPTLDAASLQAISVTENGSEHGQVTRVIAQ 833

  Fly   904 DPDVANHNALEFAGTDDITAIDKEGKELP---HYDQFKEYFKISRNGKVSVNKQ--LDRNLFAVM 963
            |.|.|....:|..   |:.. .|.|.::.   |     .:|.:..||.|.:|:.  :|.....::
Mouse   834 DVDTAALLRIELV---DVIC-TKAGVDVGSVCH-----GWFSVDGNGSVYINQSEAIDYEACHLV 889

  Fly   964 RINVLVTD-STAP--NVQQGRGLLIIQIIDVNKNPPRF--NAPWSVEQPQIKLQMVEEQPVGTVL 1023
            .:.|...| :|.|  :.....|.|:|.|.|.|.|.|.|  |....|..|::   ::..|.|.:|
Mouse   890 TLVVRAYDLNTDPGFDAYSSNGSLLINIKDKNDNAPYFLPNNQTFVIIPEL---VLPNQQVASV- 950

  Fly  1024 TTLQANDEDS---SIGEFNISDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVS-DTGVPALT 1084
               ||.||||   .|..|:|...::...:.||..:..             |::|.| :.|:  .|
Mouse   951 ---QARDEDSEDNGIIMFSILKAEFVRKDGTSNPVQV-------------FRITRSVEAGL--FT 997

  Fly  1085 ATADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHD-GDVGVFGEITYTLIGENNK 1148
            .:.::|.::                    :::.:||....|:|.| ..:|...|...||     .
Mouse   998 GSIELVTNL--------------------DSTIQGTYQVTVQAQDQPTLGPALETQTTL-----N 1037

  Fly  1149 YFSID-AYTGNVMVANSSI---LDREQIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAP 1209
            .|::| :|...:..:.|..   .:.|:|||            |.:|.:.|:...:.|.::
Mouse  1038 LFTVDQSYRVRLQFSTSKEDVGANMEEIKE------------ALIQATRTSVYVVTIQNI----- 1085

  Fly  1210 VFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEGLYGDVRYIITAGNEMGLFKL--------DA- 1265
                   :||....|:                  .|.|..::.:.|..:.|.:|        ||
Mouse  1086 -------DSTARARAS------------------SYMDAYFVFSNGTALTLTELNMMIRKDQDAL 1125

  Fly  1266 ----QSGIVYPAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNA 1326
                |.|:|               .:|::::|.....:..|..||.:          |:..:...
Mouse  1126 RQLLQLGLV---------------VVSSQESQEPDQQKLLTSVIIGL----------VVSLVLVL 1165

  Fly  1327 TIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRA--KTQL 1389
            .|.|..        |:.:|.           |||.::......:.......|.|....|  .|.:
Mouse  1166 VILITA--------LVCLRK-----------SYHRKLRAMKAGKEARKTPIETTAPTAAIPGTNM 1211

  Fly  1390 NRKNRANYDIILVARDAG-------NPPFESLRLLSVSIVDANENRPEF 1431
            ...:|||..:.|..:|.|       :..::||..|..:.||.:.:..||
Mouse  1212 YNTDRANPVLDLPTKDLGLECHSSSDLDYDSLNSLDENSVDLDMDSKEF 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	30/96 (31%)
		Cadherin_repeat	136..240	CDD:206637	29/116 (25%)
		Cadherin_repeat	248..353	CDD:206637	29/106 (27%)
		Cadherin_repeat	362..468	CDD:206637	35/131 (27%)
		Cadherin_repeat	476..>533	CDD:206637	22/59 (37%)
		E_set	<627..667	CDD:298831	14/39 (36%)
		CA	692..772	CDD:214520	22/95 (23%)
		Cadherin_repeat	778..873	CDD:206637	27/104 (26%)
		Cadherin_repeat	882..994	CDD:206637	29/120 (24%)
		Cadherin_repeat	1015..1099	CDD:206637	20/87 (23%)
		Cadherin_repeat	1108..1207	CDD:206637	21/103 (20%)
		Cadherin_repeat	1215..1314	CDD:206637	18/111 (16%)
		Cadherin_repeat	1327..1427	CDD:206637	22/108 (20%)
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
Cdhr2	NP_001028536.2	Cadherin_repeat	33..120	CDD:206637	30/95 (32%)
		Cadherin_repeat	128..236	CDD:206637	29/116 (25%)
		Cadherin_repeat	246..349	CDD:206637	30/106 (28%)
		Cadherin_repeat	372..476	CDD:206637	30/107 (28%)
		Cadherin_repeat	485..582	CDD:206637	37/190 (19%)
		Cadherin_repeat	589..691	CDD:206637	27/115 (23%)
		Cadherin_repeat	698..802	CDD:206637	27/104 (26%)
		Cadherin_repeat	815..923	CDD:206637	28/116 (24%)
		Cadherin_repeat	934..1042	CDD:206637	32/154 (21%)
		Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250\|UniProtKB:Q9BYE9	1178..1308		20/83 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1308		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24028
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010