DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and FAT2

DIOPT Version :9

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_001438.1 Gene:FAT2 / 2196 HGNCID:3596 Length:4349 Species:Homo sapiens


Alignment Length:1879 Identity:465/1879 - (24%)
Similarity:757/1879 - (40%) Gaps:407/1879 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 GADHFSVDPVSGNI-TLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDN 128
            |.|.|.:...:|.: |.....|||::||.:..|.:||...|:..::  .:|.|.|.    |:|||
Human  2008 GTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQ--GLVRVSIE----DVNDN 2066

  Fly   129 PPEFQNTPYEADVNEDAAVGTTIFDKITVKDRDIVGESLDLKCLPQQQSPEACRKFRLHIIKRDA 193
            ||:|::.||...:.:....|..:| :::..|.|     |........:..|....||:.....| 
Human  2067 PPKFKHLPYYTIIQDGTEPGDVLF-QVSATDED-----LGTNGAVTYEFAEDYTYFRIDPYLGD- 2124

  Fly   194 TILEAAVVLNDTLNYNQRMVYHFQIEATDGPHKTQTTFEARVKDVQDKP-PVFQGSLSTV-IDED 256
                  :.|....:|.....||.::.|.||...:..:.|..:..|::|. |:||.....| :.|:
Human  2125 ------ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPEN 2183

  Fly   257 SPINTLVLTVHARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREALEDSTGIISL 320
            ..:.|.:|...||   :.|..:::|:: ...|...|..|.:||.|....|||.|:.....    .
Human  2184 ITLYTPILHTQAR---SPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKHV----F 2241

  Fly   321 VIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSLLENTLPGTPLALDMSVSD 385
            .:||.:...|..|:       |...|.:.||||:||.|:...|:.|:.|. ||.....:.:..||
Human  2242 TVRATDTALGSFSE-------ATVEVLVEDVNDNPPTFSQLVYTTSISEG-LPAQTPVIQLLASD 2298

  Fly   386 ADVGINSKFALRL----DDVSGVFDVEPKLVTGYSQVNIRVANGT---------LDYENPNQRKF 437
            .|.|.|...:.::    .|||..|.:                ||:         ||||  .|:.|
Human  2299 QDSGRNRDVSYQIVEDGSDVSKFFQI----------------NGSTGEMSTVQELDYE--AQQHF 2345

  Fly   438 IVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAALPGQYIATITARDVDSG 502
            .|.|.|.:.. :|.|:....:.|:|.|.|||.|.|.|..|.|:|||.|..|..:..:.|.|.||.
Human  2346 HVKVRAMDKG-DPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSR 2409

  Fly   503 SYGDSGIRY-SLSGTGAELFHVNEQTGVISLAN-CHDNGESNRRERRDLNE-------------- 551
            .  .|.:.| .|||.....|.:|..:|:||:.| |..:.:|:...|...::              
Human  2410 D--TSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTT 2472

  Fly   552 ---------DEHVEEDD-------GEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPL 600
                     .:|:.|.:       |...:::|:::   ::.|...|:.||:|.:...|:.|..| 
Human  2473 NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID---KDSGPYGTIDYTIINKLASEKFSINP- 2533

  Fly   601 PAPVPHAAPSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDS 665
                             |...|....||.|:.|...::.|....:|.|..:..:::|.:||.||:
Human  2534 -----------------NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDN 2581

  Fly   666 PPVCESPLYRASVDEGAVVFDSPLI-VKARDAD--TMSRISYRIRGSEQVESIFDIDRETGQIII 727
            ||..::..|..|: :..|..|||:| |.|.|||  ..:.::|.:...:.|:.:.:|:..||.:.:
Human  2582 PPQFKASEYTVSI-QSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKV 2645

  Fly   728 R------PNATLDV---------TNLNS------------------------------------- 740
            :      .|.|||.         .:.||                                     
Human  2646 KDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEI 2710

  Fly   741 ---------DQLIFAV------EAN-DGLFT---------------------------AHC---- 758
                     |.:|:::      |:| ||:|:                           |||    
Human  2711 GIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNT 2775

  Fly   759 ------GVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRI--QQ 815
                  .|||.|.|||::.|.||...|.||:.||..:||||.:|.|.|.|||::.::.||:  ..
Human  2776 DVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADP 2840

  Fly   816 GS--FDDFGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQG-TPSLTGTATLTINVQNSNDKDPY 877
            ||  .:.|.|...:|.:...::||.:...||...:.|.|.| |..|:..|.:.:::.:.||..|.
Human  2841 GSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPR 2905

  Fly   878 FVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFK 942
            |........|..::.||:||.||..||.|::..|.       .:|....||..|..       |.
Human  2906 FASEEYRGSVVENSEPGELVATLKTLDADISEQNR-------QVTCYITEGDPLGQ-------FG 2956

  Fly   943 ISRNG---KVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSV 1004
            ||:.|   ::|..|.|||...|...:.|..:|...    |....:.|.::|||.|.|:      .
Human  2957 ISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF----QASVTVEIFVLDVNDNSPQ------C 3011

  Fly  1005 EQPQIKLQMVEEQPVGTVLTTLQANDEDSSIGEFNISDNDY---------FAINQTSGMIYTIAR 1060
            .|.....::.|:...|..:..:.|.|.|:...    :...|         |.::..:|.:.|:..
Human  3012 SQLLYTGKVHEDVFPGHFILKVSATDLDTDTN----AQITYSLHGPGAHEFKLDPHTGELTTLTA 3072

  Fly  1061 LDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKV 1125
            ||.| .|:| |.:....|.....:..||:.:.:.::|||.|:|..|.....|.:|:...|....|
Human  3073 LDRE-RKDV-FNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVV 3135

  Fly  1126 EAHDGDVGVFGEITYTLIGENNKYFSIDAYTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQ 1190
            .|.|.|.|...::.|:|......:|||||.|| |:.....:..|.| ..|.|:|.|.|.. ..:.
Human  3136 FARDPDQGANAQVVYSLPDSAEGHFSIDATTG-VIRLEKPLQVRPQ-APLELTVRASDLG-TPIP 3197

  Fly  1191 KSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPAA-LLQVQAIDQDEGLYGDVRYIITA 1254
            .|...|:.::::.:.|..|||....::..|.|:|   ||.. :||:..:.:...  ....|.:.:
Human  3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDA---PPGTEVLQLATLTRPGA--EKTGYRVVS 3257

  Fly  1255 GNEMGLFKLDAQSGIVYPAQSLSGKHG-AYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEF 1318
            |||.|.|:|||::||:|...||..:.. .|.|:|.. ..:.|.::...|..::.:..||.|:|:|
Human  3258 GNEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC-SRKSSSSLSDVTTVMVNITDVNEHRPQF 3321

  Fly  1319 VIPALSNATIE--IPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTG 1381
            .....|...:|  :.||::      |||.|.|.|...|..::|.|...|    |.|.|.|....|
Human  3322 PQDPYSTRVLENALVGDVI------LTVSATDEDGPLNSDITYSLIGGN----QLGHFTIHPKKG 3376

  Fly  1382 ELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDANENRPEFPDASNPYKVSINENS 1446
            ||:....|:|:..::|.:.|.|.|:|.||......:::.:.|.|:|.|.|...:  |..::.|||
Human  3377 ELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLN--YSTTVQENS 3439

  Fly  1447 GRDVKIGH-IQAASRSKHNRDIFYYMLL-GNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYILA 1509
            ....|:.. |.:...|..|...:.:.:. ||...||.|.. .|.:.|.:.|.|...:.|.|.|.|
Human  3440 PIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVTAEGLSRRAQEWYQLQIQA 3503

  Fly  1510 S----------IKADLHISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGVNA 1564
            |          ....:|::|:...:.|...|       ::.||                   |..
Human  3504 SDSGIPPLSSLTSVRVHVTEQSHYAPSALPL-------EIFIT-------------------VGE 3542

  Fly  1565 NAKMGAAITLVNATDADQGKNAKIEFMIVASNLYKFGATKSTGSIVPSPFAI-SQDGRISANTIM 1628
            :...|..:..::|||.|.....          .|.....::.|    ..|:: :.||:|      
Human  3543 DEFQGGMVGKIHATDRDPQDTL----------TYSLAEEETLG----RHFSVGAPDGKI------ 3587

  Fly  1629 AEYNQDRFELEIVARELEQPQSSASTKVNIWVFDGTQLVRVILSRPPEEVYQE----------QE 1683
                       |.|:.|.:...|.:..|:...|..|..|.|.:....:|..|:          .|
Human  3588 -----------IAAQGLPRGHYSFNVTVSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFYQLTPE 3641

  Fly  1684 EIIAE----LRNATQHRIIVDEIRFHLDSIGRIRMDWCDLYFHAVDPQTQQIAPVDEIL 1738
            |::::    |:....|::.:.....||.|:                ...:.:|.||.:|
Human  3642 ELVSDHWRNLQRFLSHKLDIKRANIHLASL----------------QPAEAVAGVDVLL 3684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 19/63 (30%)
Cadherin_repeat 136..240 CDD:206637 20/103 (19%)
Cadherin_repeat 248..353 CDD:206637 26/106 (25%)
Cadherin_repeat 362..468 CDD:206637 31/118 (26%)
Cadherin_repeat 476..>533 CDD:206637 21/57 (37%)
E_set <627..667 CDD:298831 12/39 (31%)
CA 692..772 CDD:214520 32/186 (17%)
Cadherin_repeat 778..873 CDD:206637 32/99 (32%)
Cadherin_repeat 882..994 CDD:206637 32/114 (28%)
Cadherin_repeat 1015..1099 CDD:206637 19/92 (21%)
Cadherin_repeat 1108..1207 CDD:206637 27/98 (28%)
Cadherin_repeat 1215..1314 CDD:206637 28/100 (28%)
Cadherin_repeat 1327..1427 CDD:206637 31/101 (31%)
Cadherin_repeat 1437..1549 CDD:206637 28/123 (23%)
Cadherin_repeat 1557..1662 CDD:206637 17/105 (16%)
FAT2NP_001438.1 Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..659 CDD:206637
Cadherin_repeat 719..816 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1038..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1354..1444 CDD:206637
Cadherin_repeat 1453..1551 CDD:206637
Cadherin_repeat 1559..1650 CDD:206637
Cadherin_repeat 1664..1754 CDD:206637
Cadherin_repeat 1762..1867 CDD:206637
Cadherin_repeat 1887..1963 CDD:206637
Cadherin_repeat <1998..2066 CDD:206637 19/63 (30%)
Cadherin_repeat 2074..2163 CDD:206637 19/101 (19%)
Cadherin_repeat 2176..2268 CDD:206637 27/105 (26%)
Cadherin_repeat 2276..2375 CDD:206637 31/118 (26%)
Cadherin_repeat 2383..2475 CDD:206637 25/93 (27%)
Cadherin_repeat 2486..2581 CDD:206637 24/115 (21%)
Cadherin_repeat 2589..2682 CDD:206637 23/93 (25%)
Cadherin_repeat 2696..2793 CDD:206637 17/96 (18%)
Cadherin_repeat 2801..2902 CDD:206637 33/100 (33%)
Cadherin_repeat 2910..3007 CDD:206637 32/114 (28%)
Cadherin_repeat 3016..3109 CDD:206637 19/98 (19%)
Cadherin_repeat 3120..3209 CDD:206637 27/91 (30%)
Cadherin_repeat 3224..3317 CDD:206637 28/98 (29%)
Cadherin_repeat 3325..3422 CDD:206637 32/106 (30%)
Cadherin_repeat 3431..3522 CDD:206637 23/91 (25%)
Cadherin_repeat 3535..3619 CDD:206637 23/133 (17%)
Laminin_G_2 3800..3921 CDD:280389
EGF_CA 3949..3984 CDD:238011
Cadherin_repeat 37..143 CDD:206637
Cadherin_repeat 152..247 CDD:206637
Cadherin_repeat 366..454 CDD:206637
EGF 3990..4020 CDD:278437
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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