DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and FAT1

DIOPT Version :9

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:XP_005262891.1 Gene:FAT1 / 2195 HGNCID:3595 Length:4600 Species:Homo sapiens


Alignment Length:2233 Identity:535/2233 - (23%)
Similarity:878/2233 - (39%) Gaps:548/2233 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PVFTQTLNNIILYENVTVGTVVFRLEAYDPE---GSPVTY----GAIGADHFSVDPVSGNITLIK 82
            |.||.:.....:||:..||:||.::.|.|.:   .:.|.|    |.|| :.|.:|||.|:|...|
Human  1560 PWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIG-NSFMIDPVLGSIKTAK 1623

  Fly    83 PLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDN-PPEFQNTPYEADVNEDAA 146
            .|||..:.....:|...|:..|.       :.|:....|.:.:.|| .|:|.:..|..:::|..:
Human  1624 ELDRSNQAEYDLMVKATDKGSPP-------MSEITSVRIFVTIADNASPKFTSKEYSVELSETVS 1681

  Fly   147 VGTTIFDKIT----------VKDRDIVGESLDLKCLPQQQSPEACRKFRLHIIKRDATILEAAVV 201
            :|:.: ..:|          :||.: .|::.|:       :|.:                 ..::
Human  1682 IGSFV-GMVTAHSQSSVVYEIKDGN-TGDAFDI-------NPHS-----------------GTII 1720

  Fly   202 LNDTLNYNQRMVYHFQIEATD-GPHKTQTTFEARVKDVQDKPPVF-QGSLSTVIDEDSPINTLVL 264
            ....|::....:|...|:.|: ....|.||....::|..|..||| |...:.:|.|.:.||::||
Human  1721 TQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785

  Fly   265 T-------VHARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREALEDSTGIISLV 321
            |       :.|.|.|......:||.: ..:.:.||.:|:.||.:.|...||.|    .|.|....
Human  1786 TDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE----ETSIFHFT 1846

  Fly   322 IRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSLLENTLPGTPLALDMSVSDA 386
            ::..::  |.|.  ......|..||.:.|:||.||||....|..|||..|..|..: :.::.:||
Human  1847 VQVHDM--GTPR--LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKV-ITVNATDA 1906

  Fly   387 DV-------------GINSKFALRLDDVSGVFDVEPKL----------------VTGYSQVNIRV 422
            |.             .|..||:  :|..:|...|:...                ..|.:.|.|.|
Human  1907 DSSAFSQLIYSITEGNIGEKFS--MDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINV 1969

  Fly   423 --------------------------------------ANGTLDYE--NPNQRKFI-----VL-- 440
                                                  .|..|.|.  ||::|..|     ||  
Human  1970 KESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLST 2034

  Fly   441 --------------VVAEETDTNPRLSSTATITVSVL--DANDNKPVFEQESYSASVSEAALPGQ 489
                          ||.|.|:.: :.|:.|.:.|.|:  |.|||.|||....|.|.|......|.
Human  2035 TGTPFDREQQEAFDVVVEVTEEH-KPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH 2098

  Fly   490 YIATITARDVDSGSYGDSGIRYSLSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLN--ED 552
            .|..:||.|.|||..|:  :.|.|     :..|.:.|.|.:        ||.:.:::.:|:  ..
Human  2099 VIRYVTAVDRDSGRNGE--VHYYL-----KEHHEHFQIGPL--------GEISLKKQFELDTLNK 2148

  Fly   553 EHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQA---------PEEQASSVPLPAPVPHA- 607
            |::        :.:::.:........|..|..|::.:|         ..|.|.|:.:.:||.|. 
Human  2149 EYL--------VTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQ 2205

  Fly   608 --APSGVPAATANDDKAPQT---------------CLDYESETTYFLSYKATDDNGRGSASVVSL 655
              :|.|:....:..|..|.:               .||:|:...|.||.:|| |:..|:.:.|.:
Human  2206 ANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRAT-DSLTGAHAEVFV 2269

  Fly   656 RISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVKARDADTMSR--ISYRIRGS-EQVESIFD 717
            .|.|.|.||:|||.....|..::.|.:|:..|.:.|:|.|:|:...  |||::.|: .:....|.
Human  2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFH 2334

  Fly   718 IDRETG----------------QIIIR------PN------ATLDVTNLNS-------------- 740
            :|..||                .|.:|      |.      .|:|||:||.              
Human  2335 VDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARI 2399

  Fly   741 -----------------------DQLIFAV----------------------------------- 747
                                   |:|.:::                                   
Human  2400 SEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLN 2464

  Fly   748 -EANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRY 811
             ..:||:|.:...|::||...|.|.|.|.|..|...:.||:.:.|.|..|..||.|:|....:.|
Human  2465 LSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTY 2529

  Fly   812 RIQQGSFDDFGIVETTGEVFVSRKLDFD--RRNTYQLQIQASDQGTPSLTGTATLTINV--QNSN 872
            .|......|...:...|::|...|||.:  ......:::.|.|.|..    .|..|:||  .:.|
Human  2530 HIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGK----VAFCTVNVILTDDN 2590

  Fly   873 DKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDIT-AIDKEGKELPHYDQ 936
            |..|.|........:.:.|..|..|..::|.|.|..: ||       ||| ||:.:.:.:     
Human  2591 DNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGS-NA-------DITYAIEADSESV----- 2642

  Fly   937 FKEYFKISRNGKVSVNKQ----LDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPR 997
             ||..:|::...|...|:    |:...|...   |...|:.:|: ::...|:.::|:......|:
Human  2643 -KENLEINKLSGVITTKESLIGLENEFFTFF---VRAVDNGSPS-KESVVLVYVKILPPEMQLPK 2702

  Fly   998 FNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDS---SIGEFNISD---NDYFAINQTSGMIY 1056
            |:.|:      ....:.|:.|:||.:..::|....:   |:.:.|..:   ::.|.|::.||.:.
Human  2703 FSEPF------YTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLK 2761

  Fly  1057 TIARLDYEVVKEVKFQV----TVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFNVTENSP 1117
            ....||:|..|..:|.:    |..|   ..:.|:.||.:.:.:.|||.|.|..|.|...:.||.|
Human  2762 LEKSLDHETTKWYQFSILARCTQDD---HEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823

  Fly  1118 RGTVAGKVEAHDGDVGVFGEITYTLIGENN----KYFSIDAYTGNVMVANSSILDREQIKELTLS 1178
            .|:...::.|.|.|.|..|::.|:|....:    :.|:|:..||  .:.....||.|:.....:.
Human  2824 GGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETG--WITTLKELDHEKRDNYQIK 2886

  Fly  1179 VVAQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEG 1243
            |||.|.. ..:|.|:||.:.:.:.||||:.|.||.::|..||:|:.......|:|.....|.:| 
Human  2887 VVASDHG-EKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEE- 2949

  Fly  1244 LYGDVRYIITAGNEMGLFKLDA--QSGIVYPAQSLS-GKHGAYELTISARDTQGSGTMESTTKAI 1305
            :...|.|.||.|:.:|.|.::.  ....||..:.|. .|...|.|||:|.|    ||..|.....
Human  2950 INRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD----GTFSSKAIVE 3010

  Fly  1306 ITVLRVNRHKPEFVIPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQ 1370
            :.||..|.:.|.......|:.   ||.|:: |..|::.:.|.|.|...|.:::|.|..:...   
Human  3011 VKVLDANDNSPVCEKTLYSDT---IPEDVL-PGKLIMQISATDADIRSNAEITYTLLGSGAE--- 3068

  Fly  1371 TGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIV----DANENRPEF 1431
              :||::..||||:..|.|:|:.:|.|.:::.|.|.|.      |....|||    |.|:|.|||
Human  3069 --KFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG------RFCQASIVLTLEDVNDNAPEF 3125

  Fly  1432 PDASNPYKVSINENSGRDVKIGHIQAASRSKH-NRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSL 1495
              :::||.:::.||:.....:..:||...... ||.|. |.|:.:.||.|.:::|:|.|...|.|
Human  3126 --SADPYAITVFENTEPGTLLTRVQATDADAGLNRKIL-YSLIDSADGQFSINELSGIIQLEKPL 3187

  Fly  1496 DREETDVYTLYILASIKADLHISEEERASFSIKTLN-----RDNTVAKVAITVLDVNDNPPVFEK 1555
            |||...||||                    |:|.::     |......|.::|||:||||||||.
Human  3188 DRELQAVYTL--------------------SLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEY 3232

  Fly  1556 PIYYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIVASNLY-KFGATKSTGSIVPSPFAISQD 1619
            ..|.|.|:.:..:|..:..|.|...|...||:|.:.|::.|.: ||.....||::    |.|.. 
Human  3233 REYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV----FIIEN- 3292

  Fly  1620 GRISANTIMAEY-NQDRFELEIVARELEQPQSSASTKVNIWVFD--------GTQLVRVILSRPP 1675
                     .:| :...:.|.:.|.:...|..|....||:.|.|        .......::|   
Human  3293 ---------LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVIS--- 3345

  Fly  1676 EEVYQEQEEIIAEL------RNATQHRIIVDEIR---FHLDSI-GRIR---------MDWCDLYF 1721
            |:...||..|....      .|:..|..|:|..:   |.:|.: |.::         :....|..
Human  3346 EDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTV 3410

  Fly  1722 HAVD---PQTQQIAPVDEILKDID--------RNYDYL--KDYYAGFAIENVV-----------P 1762
            .|.|   |.......|:..:.|::        .||..:  ::...||::..:|           |
Human  3411 QASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPP 3475

  Fly  1763 AYIAIV--QDE--FDLAVAGLVALVIVLFVGVISFIVLCCCLK-----HWNLSVPVETRRKEALI 1818
            .:..||  .||  |::...|:              ::....:|     |:.|.|.|....|..|.
Human  3476 FFFTIVTGNDEKAFEVNPQGV--------------LLTSSAIKRKEKDHYLLQVKVADNGKPQLS 3526

  Fly  1819 KKQIIEDLNTTENPLWIEQKLKLYEEQELTMQVFSEPDHISNSEAPGHLDHRSSLEQVHHVGQTV 1883
            ....| |:...|.        .:|....|.:::|...   |..|..|.:     :.::|...|.|
Human  3527 SLTYI-DIRVIEE--------SIYPPAILPLEIFITS---SGEEYSGGV-----IGKIHATDQDV 3574

  Fly  1884 DN--TYATIQPRNNQNRLTGGGG 1904
            .:  ||:.....:|...::..||
Human  3575 YDTLTYSLDPQMDNLFSVSSTGG 3597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 28/101 (28%)
Cadherin_repeat 136..240 CDD:206637 17/114 (15%)
Cadherin_repeat 248..353 CDD:206637 29/112 (26%)
Cadherin_repeat 362..468 CDD:206637 38/197 (19%)
Cadherin_repeat 476..>533 CDD:206637 17/56 (30%)
E_set <627..667 CDD:298831 16/39 (41%)
CA 692..772 CDD:214520 30/183 (16%)
Cadherin_repeat 778..873 CDD:206637 25/98 (26%)
Cadherin_repeat 882..994 CDD:206637 25/116 (22%)
Cadherin_repeat 1015..1099 CDD:206637 22/93 (24%)
Cadherin_repeat 1108..1207 CDD:206637 30/102 (29%)
Cadherin_repeat 1215..1314 CDD:206637 31/101 (31%)
Cadherin_repeat 1327..1427 CDD:206637 31/103 (30%)
Cadherin_repeat 1437..1549 CDD:206637 34/117 (29%)
Cadherin_repeat 1557..1662 CDD:206637 26/106 (25%)
FAT1XP_005262891.1 Cadherin_repeat 38..144 CDD:206637
Cadherin_repeat 153..252 CDD:206637
E_set 277..356 CDD:298831
Cadherin_repeat 371..459 CDD:206637
Cadherin_repeat 468..565 CDD:206637
Cadherin_repeat 575..663 CDD:206637
Cadherin_repeat 724..818 CDD:206637
Cadherin_repeat 826..923 CDD:206637
Cadherin_repeat 932..1016 CDD:206637
Cadherin_repeat 1042..1135 CDD:206637
Cadherin_repeat 1143..1241 CDD:206637
Cadherin_repeat 1250..1344 CDD:206637
Cadherin_repeat 1363..1452 CDD:206637
Cadherin_repeat 1461..1558 CDD:206637
Cadherin_repeat 1566..1658 CDD:206637 28/99 (28%)
Cadherin_repeat 1671..1761 CDD:206637 17/115 (15%)
Cadherin_repeat 1769..1874 CDD:206637 29/112 (26%)
Cadherin_repeat 1895..1970 CDD:206637 13/77 (17%)
Cadherin_repeat 1983..2077 CDD:206637 19/94 (20%)
Cadherin_repeat 2085..2174 CDD:206637 23/111 (21%)
Cadherin_repeat 2187..2279 CDD:206637 25/92 (27%)
Cadherin_repeat 2287..2386 CDD:206637 25/98 (26%)
Cadherin_repeat 2394..2488 CDD:206637 9/93 (10%)
Cadherin_repeat 2496..2592 CDD:206637 26/99 (26%)
Cadherin_repeat 2601..2694 CDD:206637 24/110 (22%)
Cadherin_repeat 2708..2805 CDD:206637 22/99 (22%)
Cadherin_repeat 2813..2913 CDD:206637 29/102 (28%)
Cadherin_repeat 2922..3019 CDD:206637 31/101 (31%)
Cadherin_repeat 3028..3121 CDD:206637 32/107 (30%)
Cadherin_repeat 3129..3226 CDD:206637 34/117 (29%)
Cadherin_repeat 3234..3331 CDD:206637 27/110 (25%)
Cadherin_repeat 3339..3436 CDD:206637 18/99 (18%)
Cadherin_repeat 3445..3536 CDD:206637 20/105 (19%)
Cadherin_repeat 3561..3634 CDD:206637 9/42 (21%)
LamG 3854..3985 CDD:214598
EGF_CA 4016..4050 CDD:238011
EGF_CA 4053..4088 CDD:238011
EGF 4093..4123 CDD:278437
EGF_CA 4127..4163 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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