DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and FAT1

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_001427385.1 Gene:FAT1 / 2195 HGNCID:3595 Length:4600 Species:Homo sapiens


Alignment Length:2233 Identity:535/2233 - (23%)
Similarity:878/2233 - (39%) Gaps:548/2233 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 PVFTQTLNNIILYENVTVGTVVFRLEAYDPE---GSPVTY----GAIGADHFSVDPVSGNITLIK 82
            |.||.:.....:||:..||:||.::.|.|.:   .:.|.|    |.|| :.|.:|||.|:|...|
Human  1560 PWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIG-NSFMIDPVLGSIKTAK 1623

  Fly    83 PLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDN-PPEFQNTPYEADVNEDAA 146
            .|||..:.....:|...|:..|.       :.|:....|.:.:.|| .|:|.:..|..:::|..:
Human  1624 ELDRSNQAEYDLMVKATDKGSPP-------MSEITSVRIFVTIADNASPKFTSKEYSVELSETVS 1681

  Fly   147 VGTTIFDKIT----------VKDRDIVGESLDLKCLPQQQSPEACRKFRLHIIKRDATILEAAVV 201
            :|:.: ..:|          :||.: .|::.|:       :|.:                 ..::
Human  1682 IGSFV-GMVTAHSQSSVVYEIKDGN-TGDAFDI-------NPHS-----------------GTII 1720

  Fly   202 LNDTLNYNQRMVYHFQIEATD-GPHKTQTTFEARVKDVQDKPPVF-QGSLSTVIDEDSPINTLVL 264
            ....|::....:|...|:.|: ....|.||....::|..|..||| |...:.:|.|.:.||::||
Human  1721 TQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVL 1785

  Fly   265 T-------VHARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRTAKPLDREALEDSTGIISLV 321
            |       :.|.|.|......:||.: ..:.:.||.:|:.||.:.|...||.|    .|.|....
Human  1786 TDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE----ETSIFHFT 1846

  Fly   322 IRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYSVSLLENTLPGTPLALDMSVSDA 386
            ::..::  |.|.  ......|..||.:.|:||.||||....|..|||..|..|..: :.::.:||
Human  1847 VQVHDM--GTPR--LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKV-ITVNATDA 1906

  Fly   387 DV-------------GINSKFALRLDDVSGVFDVEPKL----------------VTGYSQVNIRV 422
            |.             .|..||:  :|..:|...|:...                ..|.:.|.|.|
Human  1907 DSSAFSQLIYSITEGNIGEKFS--MDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINV 1969

  Fly   423 --------------------------------------ANGTLDYE--NPNQRKFI-----VL-- 440
                                                  .|..|.|.  ||::|..|     ||  
Human  1970 KESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLST 2034

  Fly   441 --------------VVAEETDTNPRLSSTATITVSVL--DANDNKPVFEQESYSASVSEAALPGQ 489
                          ||.|.|:.: :.|:.|.:.|.|:  |.|||.|||....|.|.|......|.
Human  2035 TGTPFDREQQEAFDVVVEVTEEH-KPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH 2098

  Fly   490 YIATITARDVDSGSYGDSGIRYSLSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLN--ED 552
            .|..:||.|.|||..|:  :.|.|     :..|.:.|.|.:        ||.:.:::.:|:  ..
Human  2099 VIRYVTAVDRDSGRNGE--VHYYL-----KEHHEHFQIGPL--------GEISLKKQFELDTLNK 2148

  Fly   553 EHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQA---------PEEQASSVPLPAPVPHA- 607
            |::        :.:::.:........|..|..|::.:|         ..|.|.|:.:.:||.|. 
Human  2149 EYL--------VTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQ 2205

  Fly   608 --APSGVPAATANDDKAPQT---------------CLDYESETTYFLSYKATDDNGRGSASVVSL 655
              :|.|:....:..|..|.:               .||:|:...|.||.:|| |:..|:.:.|.:
Human  2206 ANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRAT-DSLTGAHAEVFV 2269

  Fly   656 RISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVKARDADTMSR--ISYRIRGS-EQVESIFD 717
            .|.|.|.||:|||.....|..::.|.:|:..|.:.|:|.|:|:...  |||::.|: .:....|.
Human  2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFH 2334

  Fly   718 IDRETG----------------QIIIR------PN------ATLDVTNLNS-------------- 740
            :|..||                .|.:|      |.      .|:|||:||.              
Human  2335 VDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARI 2399

  Fly   741 -----------------------DQLIFAV----------------------------------- 747
                                   |:|.:::                                   
Human  2400 SEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLN 2464

  Fly   748 -EANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRY 811
             ..:||:|.:...|::||...|.|.|.|.|..|...:.||:.:.|.|..|..||.|:|....:.|
Human  2465 LSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTY 2529

  Fly   812 RIQQGSFDDFGIVETTGEVFVSRKLDFD--RRNTYQLQIQASDQGTPSLTGTATLTINV--QNSN 872
            .|......|...:...|::|...|||.:  ......:::.|.|.|..    .|..|:||  .:.|
Human  2530 HIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGK----VAFCTVNVILTDDN 2590

  Fly   873 DKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDIT-AIDKEGKELPHYDQ 936
            |..|.|........:.:.|..|..|..::|.|.|..: ||       ||| ||:.:.:.:     
Human  2591 DNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGS-NA-------DITYAIEADSESV----- 2642

  Fly   937 FKEYFKISRNGKVSVNKQ----LDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQIIDVNKNPPR 997
             ||..:|::...|...|:    |:...|...   |...|:.:|: ::...|:.::|:......|:
Human  2643 -KENLEINKLSGVITTKESLIGLENEFFTFF---VRAVDNGSPS-KESVVLVYVKILPPEMQLPK 2702

  Fly   998 FNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDS---SIGEFNISD---NDYFAINQTSGMIY 1056
            |:.|:      ....:.|:.|:||.:..::|....:   |:.:.|..:   ::.|.|::.||.:.
Human  2703 FSEPF------YTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLK 2761

  Fly  1057 TIARLDYEVVKEVKFQV----TVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFNVTENSP 1117
            ....||:|..|..:|.:    |..|   ..:.|:.||.:.:.:.|||.|.|..|.|...:.||.|
Human  2762 LEKSLDHETTKWYQFSILARCTQDD---HEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823

  Fly  1118 RGTVAGKVEAHDGDVGVFGEITYTLIGENN----KYFSIDAYTGNVMVANSSILDREQIKELTLS 1178
            .|:...::.|.|.|.|..|::.|:|....:    :.|:|:..||  .:.....||.|:.....:.
Human  2824 GGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETG--WITTLKELDHEKRDNYQIK 2886

  Fly  1179 VVAQDKAPAAVQKSATATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPAALLQVQAIDQDEG 1243
            |||.|.. ..:|.|:||.:.:.:.||||:.|.||.::|..||:|:.......|:|.....|.:| 
Human  2887 VVASDHG-EKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEE- 2949

  Fly  1244 LYGDVRYIITAGNEMGLFKLDA--QSGIVYPAQSLS-GKHGAYELTISARDTQGSGTMESTTKAI 1305
            :...|.|.||.|:.:|.|.::.  ....||..:.|. .|...|.|||:|.|    ||..|.....
Human  2950 INRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD----GTFSSKAIVE 3010

  Fly  1306 ITVLRVNRHKPEFVIPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQ 1370
            :.||..|.:.|.......|:.   ||.|:: |..|::.:.|.|.|...|.:::|.|..:...   
Human  3011 VKVLDANDNSPVCEKTLYSDT---IPEDVL-PGKLIMQISATDADIRSNAEITYTLLGSGAE--- 3068

  Fly  1371 TGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIV----DANENRPEF 1431
              :||::..||||:..|.|:|:.:|.|.:::.|.|.|.      |....|||    |.|:|.|||
Human  3069 --KFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG------RFCQASIVLTLEDVNDNAPEF 3125

  Fly  1432 PDASNPYKVSINENSGRDVKIGHIQAASRSKH-NRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSL 1495
              :::||.:::.||:.....:..:||...... ||.|. |.|:.:.||.|.:::|:|.|...|.|
Human  3126 --SADPYAITVFENTEPGTLLTRVQATDADAGLNRKIL-YSLIDSADGQFSINELSGIIQLEKPL 3187

  Fly  1496 DREETDVYTLYILASIKADLHISEEERASFSIKTLN-----RDNTVAKVAITVLDVNDNPPVFEK 1555
            |||...||||                    |:|.::     |......|.::|||:||||||||.
Human  3188 DRELQAVYTL--------------------SLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEY 3232

  Fly  1556 PIYYAGVNANAKMGAAITLVNATDADQGKNAKIEFMIVASNLY-KFGATKSTGSIVPSPFAISQD 1619
            ..|.|.|:.:..:|..:..|.|...|...||:|.:.|::.|.: ||.....||::    |.|.. 
Human  3233 REYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAV----FIIEN- 3292

  Fly  1620 GRISANTIMAEY-NQDRFELEIVARELEQPQSSASTKVNIWVFD--------GTQLVRVILSRPP 1675
                     .:| :...:.|.:.|.:...|..|....||:.|.|        .......::|   
Human  3293 ---------LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVIS--- 3345

  Fly  1676 EEVYQEQEEIIAEL------RNATQHRIIVDEIR---FHLDSI-GRIR---------MDWCDLYF 1721
            |:...||..|....      .|:..|..|:|..:   |.:|.: |.::         :....|..
Human  3346 EDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTV 3410

  Fly  1722 HAVD---PQTQQIAPVDEILKDID--------RNYDYL--KDYYAGFAIENVV-----------P 1762
            .|.|   |.......|:..:.|::        .||..:  ::...||::..:|           |
Human  3411 QASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPP 3475

  Fly  1763 AYIAIV--QDE--FDLAVAGLVALVIVLFVGVISFIVLCCCLK-----HWNLSVPVETRRKEALI 1818
            .:..||  .||  |::...|:              ::....:|     |:.|.|.|....|..|.
Human  3476 FFFTIVTGNDEKAFEVNPQGV--------------LLTSSAIKRKEKDHYLLQVKVADNGKPQLS 3526

  Fly  1819 KKQIIEDLNTTENPLWIEQKLKLYEEQELTMQVFSEPDHISNSEAPGHLDHRSSLEQVHHVGQTV 1883
            ....| |:...|.        .:|....|.:::|...   |..|..|.:     :.::|...|.|
Human  3527 SLTYI-DIRVIEE--------SIYPPAILPLEIFITS---SGEEYSGGV-----IGKIHATDQDV 3574

  Fly  1884 DN--TYATIQPRNNQNRLTGGGG 1904
            .:  ||:.....:|...::..||
Human  3575 YDTLTYSLDPQMDNLFSVSSTGG 3597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 28/101 (28%)
Cadherin_repeat 136..240 CDD:206637 17/114 (15%)
Cadherin_repeat 248..353 CDD:206637 29/112 (26%)
Cadherin_repeat 362..468 CDD:206637 38/197 (19%)
Cadherin_repeat 476..>533 CDD:206637 17/56 (30%)
CA_like <627..667 CDD:481204 16/39 (41%)
CA 692..772 CDD:214520 30/183 (16%)
Cadherin_repeat 778..873 CDD:206637 25/98 (26%)
Cadherin_repeat 882..994 CDD:206637 25/116 (22%)
Cadherin_repeat 1015..1099 CDD:206637 22/93 (24%)
Cadherin_repeat 1108..1207 CDD:206637 30/102 (29%)
Cadherin_repeat 1215..1314 CDD:206637 31/101 (31%)
Cadherin_repeat 1327..1427 CDD:206637 31/103 (30%)
Cadherin_repeat 1437..1549 CDD:206637 34/117 (29%)
Cadherin_repeat 1557..1662 CDD:206637 26/106 (25%)
FAT1NP_001427385.1 Nuclear localization signal. /evidence=ECO:0000255 4204..4214
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4255..4275
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4303..4327
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4343..4376
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4447..4491
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4577..4600
Blue background indicates that the domain is not in the aligned region.

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