DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and cdh-8

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_001294412.1 Gene:cdh-8 / 184652 WormBaseID:WBGene00017576 Length:1684 Species:Caenorhabditis elegans


Alignment Length:1948 Identity:445/1948 - (22%)
Similarity:764/1948 - (39%) Gaps:498/1948 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LLMICLGLTLAKGETN----LPPVFTQTLNNIILYENVTVGTVVFRLEAYDPEGSPVTYGAIGAD 67
            :|:.||     ||..:    :.|.|      :::.|:..|||.:           |||.......
 Worm    12 ILLGCL-----KGTDSAQLLIEPSF------LLVEEDWPVGTHL-----------PVTICPKNVK 54

  Fly    68 HFSVDPVSGNITLIK--------------PLDREEKDTLK---FLVSIRDRVDPEGESERDNVVE 115
            ..|.||.| ..|::|              ..|:|..|.|:   |.:.|      .|..:....:|
 Worm    55 ILSGDPAS-YFTVVKINETCSTLQLNLALDADKENADGLRGQSFSLVI------AGPKKSRATLE 112

  Fly   116 VPITFIILDLNDNPPEFQNTPYEADVNEDAAVGTTIFDKITVKDRD--IVGESLDLKCLPQQQSP 178
            |.    |:|:|||.|:|.|||...:::|:|.:||.|| |:|..|.|  |.|.|        :.|.
 Worm   113 VQ----IVDVNDNSPQFSNTPSSFEISENAEIGTDIF-KVTTLDPDTGISGIS--------RFSV 164

  Fly   179 EACRKFRLHIIKRDATILEAAVVLNDTLNYNQRMVYHFQIEATDG-PHKTQT-----TFEARVKD 237
            |....|.|...|..:......:.|...|::.::.::.|.|.|.|| ||..:|     |....||:
 Worm   165 EGDSSFTLAKRKCSSGKCSTQLRLAKKLDFEEKPIHTFNITAKDGDPHSNRTHTVAHTVTIHVKN 229

  Fly   238 VQDKPPVFQGSLSTV--IDEDSPINTLVLTVHARDGDTGEPRKIVYDLRTNPNDYFLLDAQTGEL 300
            ..|:||.|....|.|  |.:.:....::..:.|.|.:.|  .:|.:.::  .|::..:|:::|.:
 Worm   230 ENDEPPKFLTDFSQVFPIFKSTKPGDIIAKLEAIDVENG--AEIQFGMK--ENEHLKIDSKSGNV 290

  Fly   301 RTAKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKAT-----------VTIRDVNDS 354
                                      |:..:|:||.|.:....||           :.:|.:||.
 Worm   291 --------------------------LLKKLPTDDALITVELYATSSKNGKSKTVEMKLRLMNDE 329

  Fly   355 ---PPVFNHKE---------YSVSLLENT-LPGTPLALDMSVSDAD-----VGINSKFALR-LDD 400
               |.:..::|         |...|::.| ...|||.:....|.|:     :|.:..|.|. :||
 Worm   330 ATLPKIAENQEKPELCEFPIYEAHLIQGTGTFSTPLKIKTLKSMAEEKPRLIGGSESFDLNVIDD 394

  Fly   401 VSGVFDVEPKLVTGYSQVNIRVANGTLD------YENPNQRKFIVLVVAEETDTNPRLSSTATIT 459
                |.||.|::...     :||:..||      .....|.:.::...|:.|   |:.|..|. .
 Worm   395 ----FHVELKVLNAE-----KVASQVLDSAQLLVKSQSGQCRIVLRSAAQMT---PKASPIAQ-K 446

  Fly   460 VSVLDANDNKPVFEQESYSASVSEAALP---GQYIATITARDVDSGSYGDSGIRYSLSGTGAELF 521
            :.::      |.||:..|...|.|...|   |: :..|:          |..:.|.:.|...|.|
 Worm   447 LKII------PKFEKSEYQFQVVENREPTVLGE-VKVIS----------DGPVTYEILGENGEKF 494

  Fly   522 HVNEQTGVISLANCHDNGESNRRERRDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTL 586
            .::                                 :|||  ::.|           ||      
 Worm   495 QIS---------------------------------NDGE--IQNL-----------EP------ 507

  Fly   587 ITQAPEEQASSVPLPAPVPHAAPSGVPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSAS 651
                                                    :|.|:...:.|..||||.||....|
 Worm   508 ----------------------------------------IDRETYEKFELIVKATDLNGSSGKS 532

  Fly   652 VVSLRISVTDANDSPPVCESPLYRASVDEGAVVFDSPLIVKARDADT--MSRISYRIRGSEQVES 714
              .|.|.|.|.||:.|:.:...|..:||||.   ...|.:.|.|||:  ..:|.|.|  .:::::
 Worm   533 --QLIIHVKDENDNSPIFDKEHYFITVDEGK---SEKLKITATDADSGKNGQIVYSI--DQKIDN 590

  Fly   715 I-FDIDRETGQIIIRPNATLDVTNL-NSDQLIFAVEANDG---LFTAHCGVNITVRDVNNHVPNF 774
            : .||..: |.:.|   ..:|..|: ||:::...|.|:|.   ..:|...|.|.|:|:|::.|.|
 Worm   591 LPIDISPD-GMLFI---GAIDRENMGNSNEVNLTVTASDSGEPKRSASATVTIRVKDINDNSPVF 651

  Fly   775 EQQSYSAVVEENSEIGTSVERVHATDLD-TGKNAELRYRIQQGSFDDFGIVETTGEVFVSRKLDF 838
            ....||..::.|...|..:.|:.|||.| |..|..:.|.    |.|....|..:||:..:.....
 Worm   652 SNSRYSIPLDANISPGGIIGRLEATDADSTSPNNYVTYT----SGDPKFTVSDSGEILFTGPGTL 712

  Fly   839 DRRNTYQLQIQASDQGTPSLTGTATLTINVQ--------------NSNDKDPYFVPATQHAEVR- 888
            ::..:.:..:.|.|.|.|..:..|.:.||..              ||||      ...:.:|:: 
 Worm   713 EKSASLEFNVTAQDGGDPMNSANALVVINEHRSMKSIENELTTQINSND------TGGEKSEIKW 771

  Fly   889 -ADAPPGQLVYTLIALDPDVANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSVN 952
             ....||   ||.     ::...:|..|:.::..|.|..:                |::|::...
 Worm   772 LNAGMPG---YTY-----EIIRASADGFSDSEVATWISID----------------SKSGRIYTL 812

  Fly   953 KQLDRNLFAVMRINVLVTDSTAPNVQQGRG----LLIIQIIDVNKNPPRFNAPWSVEQPQIKLQM 1013
            |::|.:....:::::        ::::|:.    .|||.::|.:...|.::.|..      ||.:
 Worm   813 KKVDPSRVKQIKLHI--------SMRKGKREVPVELIINVMDTDDVTPIYSTPTR------KLSV 863

  Fly  1014 VEEQPVGTVLTTLQANDEDSSIGEFNISDNDYFAINQTS-----------GMIYTIARLDYE--- 1064
            .|...:||.:.       |..:......:...:::..||           |.|..|..||:|   
 Worm   864 TESATLGTTVV-------DMPVEGIKEQNEIKYSLKITSGPRGKLQIDRYGTIKIIKSLDFETEQ 921

  Fly  1065 VVKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKF-SQSDYYFNVTENSPRGTVAGKVE-- 1126
            ::|.:...:.|.:    ...|.:..::.|::.|||.|.| :.|::..::.|:|..|||.....  
 Worm   922 IIKGIVEGMVVKN----GKAAKSSFILTILDANDNRPIFKNSSNFAVSLLESSVLGTVLDLPYPL 982

  Fly  1127 AHDGDVGVFGEITYTLIGENNKYFSIDAYTGNVMVANSSI-----LDREQIKELTLSVVAQDKAP 1186
            |.|.|...|..:.|::.|:.. ||.||.       :||:|     ||.|..:..:||:...|...
 Worm   983 ATDRDSSKFSTLKYSMTGDEG-YFKIDE-------SNSTIRLVAPLDFETQRVHSLSIKCVDNQG 1039

  Fly  1187 AAVQKSATATIHINILDVNDNAPVF-TRDVYNSTVAENAAYQPPAALLQVQAIDQDEGLYGDVRY 1250
            ........|::.:.::||||||||. ..|:.:.::.|:|.......:|.:.  |.|||  |..:.
 Worm  1040 REPHHEVFASVTVTVIDVNDNAPVIHNTDLTHLSIEEDAQVGQVVTVLVIS--DSDEG--GVQKT 1100

  Fly  1251 IITAGNEMGLFKLDAQSGIVYPAQSLSGKHGAYEL--TISARDTQGSGTMESTTKAIITVLRV-N 1312
            .|...:.  ||:.|:...:|..| ||.| |....:  |::|.|.   |.:.:|:...:||... |
 Worm  1101 EIDVNST--LFRADSDKKLVVIA-SLKG-HAGQRICSTVTATDV---GGLRATSPYCVTVYPAKN 1158

  Fly  1313 RHKPEFVIPALSNATIEIPGDIVQPDYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKID 1377
            .|....||....|:......:||..:.|.:.|...|.|.   |.|::.|....:.:.|.  |.|.
 Worm  1159 THHNPLVITPKQNSIHYFDENIVYDELLKVKVLEEDGDI---GNVTFRLDEMFKKDWQM--FTIG 1218

  Fly  1378 EVTGELRAKTQLNRKNRANYDIILVARDAGNPPFESLRLLSVSIVDANENRPEFPDASNPYKVSI 1442
            |:.|.|.|:...:.:.:..::|.::|....|  ..|..|. :|:.|.|:|.|.||  ....::::
 Worm  1219 EINGSLHARQAFDFEKKTVHEIKILACRINN--CTSTHLF-ISVNDRNDNCPMFP--KQDVRLTV 1278

  Fly  1443 NENSGRDVKIGHIQAASRSKHNRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDREETDVYTLYI 1507
            .||.....::|.|.||..|..:.|........:....|:.|.....::||.|.|||....:.:.|
 Worm  1279 LENEKGKRQVGRIPAALDSDFHSDNTKVCYTTDTPLFFFSDPTLPILFTNSSFDREHKKQHQISI 1343

  Fly  1508 LASIKADLHISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAG-VNANAKMGAA 1571
            .|   .|.|:|..:    ..|.:|  .|:..: |.|||:|||.|.|.:.||.:. |..:...|:.
 Worm  1344 TA---YDCHLSCRD----PHKPIN--GTIVAL-IDVLDINDNFPKFSEKIYTSTVVQGHVTTGSH 1398

  Fly  1572 ITLVNATDADQGKNAKIEFMI---VASNLYKFGAT-------KSTGSIVPSPFAISQDGRISANT 1626
            |..|.|||.|:.... :::.|   |.|..:.|.|.       ||||.:  |...|.:|...|...
 Worm  1399 ILTVQATDLDEEPEG-LKYSIRGFVRSPSHSFVAAESPISIDKSTGEL--SATEILKDSSYSFTV 1460

  Fly  1627 IMAEYNQDRFELEIVARELE-QPQSSASTKVNIWVFDGTQLVRVILSRPPEEVYQEQEEIIAELR 1690
            ::.:.........:|..:|. :..::||.::::..:  .|...::...|.|.:.:.:::|...|.
 Worm  1461 VVTDGAGHEDTASVVVIDLSYELSTNASFQISVVTY--AQQTELVFDAPFELIMKNEKKIAENLS 1523

  Fly  1691 NATQHRIIVDEIR----FHLDSIGRIRMDWCDLYFHAVDPQTQQIAPVDEILKDIDRNYDY---- 1747
            |||..:.|||:.|    |.|            :..|.:|...|.:        ::||..:.    
 Worm  1524 NATGLQTIVDKCRQNANFTL------------MLVHFMDINGQFV--------NVDRAVNLLMSS 1568

  Fly  1748 -------------LKDYYAGFAIENVVPAYIAIVQDEFDLAVAGLVALVIVLFVGVISFIVLC 1797
                         |::.:....|.:.||.||             |:|:::...:.::|..:.|
 Worm  1569 SAESRRELRSVYGLREAFPPVPIPSKVPQYI-------------LIAVLLFFVISILSMCIWC 1618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637 25/111 (23%)
Cadherin_repeat 136..240 CDD:206637 32/111 (29%)
Cadherin_repeat 248..353 CDD:206637 18/117 (15%)
Cadherin_repeat 362..468 CDD:206637 28/127 (22%)
Cadherin_repeat 476..>533 CDD:206637 11/59 (19%)
CA_like <627..667 CDD:481204 16/39 (41%)
CA 692..772 CDD:214520 24/86 (28%)
Cadherin_repeat 778..873 CDD:206637 26/109 (24%)
Cadherin_repeat 882..994 CDD:206637 18/117 (15%)
Cadherin_repeat 1015..1099 CDD:206637 17/97 (18%)
Cadherin_repeat 1108..1207 CDD:206637 28/105 (27%)
Cadherin_repeat 1215..1314 CDD:206637 26/101 (26%)
Cadherin_repeat 1327..1427 CDD:206637 24/99 (24%)
Cadherin_repeat 1437..1549 CDD:206637 29/111 (26%)
Cadherin_repeat 1557..1662 CDD:206637 27/116 (23%)
cdh-8NP_001294412.1 Cadherin_repeat <55..121 CDD:206637 18/76 (24%)
Cadherin_repeat 131..232 CDD:206637 31/109 (28%)
Cadherin_repeat 457..544 CDD:206637 32/191 (17%)
Cadherin_repeat 552..647 CDD:206637 30/103 (29%)
Cadherin_repeat 656..741 CDD:206637 22/88 (25%)
Cadherin_repeat 861..952 CDD:206637 18/101 (18%)
Cadherin_repeat 964..1060 CDD:206637 28/103 (27%)
Cadherin_repeat 1184..1265 CDD:206637 22/88 (25%)
Cadherin_repeat 1275..1375 CDD:206637 29/109 (27%)
Cadherin_repeat 1396..1476 CDD:206637 20/82 (24%)

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