DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad87A and Cdhr1

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	NP_570948.1	Gene:	Cdhr1 / 170677	MGIID:	2157782	Length:	859	Species:	Mus musculus

Alignment Length:	1070	Identity:	272/1070 - (25%)
Similarity:	424/1070 - (39%)	Gaps:	306/1070 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPLGLLMICLGLTLAKGETNLPPVF-----TQTLNNIILY---ENVTVGTVVFRLEAYDPEGSPV 59
            |.||||.|.|      .:.|..|.|     ..|..|:.|:   |:..||:.|:.|...||||.|:
Mouse     9 LVLGLLRIYL------AQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPI 67

  Fly    60 TYGAIGADH-----FSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPIT 119
            :| .|..|.     |||||..|||||::.||||.:|.::.::||.|.:         |:|...:.
Mouse    68 SY-HISFDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGL---------NLVAEKVV 122

  Fly   120 FIILDLNDNPPEFQNTPYEADVNEDAAVGTTIFDKITVKDRDI-VGESLDLKCLPQQQSPEACRK 183
            .::.|.||..|.|...||...|.|:...|::|| |:..:|:|. .|.|:.........|     |
Mouse   123 ILVTDANDEAPRFIQEPYIIRVPENIPAGSSIF-KVQAEDKDTGSGGSVTYSLQNLHSS-----K 181

  Fly   184 FRLHIIKRDATILEAAVVLNDTLNYNQRMVYHFQIEATDGPHKTQ---------TTFEARVKDVQ 239
            |.:   .|.:.:|.  :....||:|.:...::..:.|.||..:.:         ||....|:|||
Mouse   182 FSM---DRHSGVLR--LQAGATLDYEKSRAHYITVIAKDGGGRLRGADMVFSATTTVTINVEDVQ 241

  Fly   240 DKPPVFQGS-LSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDLRTNPNDYFLLDAQTGE---L 300
            |..|:|.|: ....:.||:...:.||||.|.|||.|:|..|:|.|....:..|.::..:|.   |
Mouse   242 DTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNESDGIFEINETSGAISVL 306

  Fly   301 RTAKPLDREALEDSTGIISLVIRARELVNGVPSDDPLTSATAKATVTIRDVNDSPPVF-----NH 360
            ::...|.||..|       |.::..| ||...|  |...||...|:.|.|:|:.||.|     ..
Mouse   307 QSPALLRREVYE-------LHVQVTE-VNSPGS--PAAQATVPVTIRIVDLNNHPPTFYGESGPQ 361

  Fly   361 KEYSVSLLENTLPGTPL-ALDMSVSDADVGINSKFALRLDDVSGVFDVEPKLVTGYSQVNIRVAN 424
            .::.:|:.|:...|..| .|.::|:|:|.|.|:||.|||....|:|.|.|:.|...:||.|.|.|
Mouse   362 NKFELSMFEHPPQGEILRGLKITVNDSDQGANAKFNLRLVGPGGIFRVVPQTVLNEAQVTIIVEN 426

  Fly   425 -GTLDYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAALPG 488
             ..:|:|......|.:|.:  |.:|..:.||||.|.:.:||.|||.|.|....|.|.:.|.|..|
Mouse   427 SAAIDFEKSKLLTFKLLAI--EVNTPEKFSSTADIVIQLLDTNDNVPKFTSHYYIARIPENAPGG 489

  Fly   489 QYIATITARDVDSGSYGDSGIRYSLSGTGAELFHVNEQTGVISLANCHDNGESNRRERRDLNEDE 553
            ..:..:||.|.|:|.:|.  :.||:.|||::||.::..||:|
Mouse   490 SNVVAVTAVDPDTGPWGK--VHYSIYGTGSDLFLIHPSTGLI----------------------- 529

  Fly   554 HVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPSGVPAATAN 618
                                          ||
Mouse   530 ------------------------------YT--------------------------------- 531

  Fly   619 DDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRASVDEGAV 683
               .|...||.|..:.|....||.|.:||  .|:..:.:::.|.||     ..|.:..||.|..:
Mouse   532 ---QPWASLDAEGTSRYNFYVKAEDMDGR--YSLAEVFVTLLDVND-----HYPQFVQSVQEKTM 586

  Fly   684 VFDSPLIVKARDADT---MSRISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTNLNSDQLIF 745
            |..:||.::|.|.|.   .:.:.|.|..:|.| ::||||..||:|.::          ||   |.
Mouse   587 VLGTPLKIEATDQDAEEPNNLVDYSITRAEPV-NVFDIDAHTGEIRLK----------NS---IR 637

  Fly   746 AVEANDGLFTAHCGVNITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELR 810
            ::||                 ::|..|:
Mouse   638 SLEA-----------------LHNITPS------------------------------------- 648

  Fly   811 YRIQQGSFDDFGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQN----S 871
                 |.:                        ::.||:||.|:|:||.:.||.|.|::.:    |
Mouse   649 -----GDY------------------------SWSLQVQAKDRGSPSFSTTALLKIDITDTERLS 684

  Fly   872 NDKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNALEFAGTDDI----TAIDKEGKELP 932
            ......|:..|:...::|......::..::|:...::.........::.:    ..:.:.....|
Mouse   685 RGSMAAFLIQTKDNPMKAVGVLAGVMAIVVAITVLISTATFWRNKKSNKVLPVRRVLRRRPSPAP 749

  Fly   933 HYDQFKEYFKISRNGKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGR-GLLIIQIIDVNKNPP 996
            |..:. |:.|. |..|.:..             .:|..||...|....| |:::         ||
Mouse   750 HTVRI-EWLKF-RRAKAATK-------------FILKEDSPNENCNNSRVGVMV---------PP 790

  Fly   997 RFNAPWSVEQPQIKLQMVEEQPVGTVLTTL 1026
            |  ||.....|::...||.:|.|.||..:|
Mouse   791 R--APALPPPPKMASSMVAQQTVPTVSGSL 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	37/102 (36%)
		Cadherin_repeat	136..240	CDD:206637	28/113 (25%)
		Cadherin_repeat	248..353	CDD:206637	33/108 (31%)
		Cadherin_repeat	362..468	CDD:206637	39/107 (36%)
		Cadherin_repeat	476..>533	CDD:206637	21/56 (38%)
		E_set	<627..667	CDD:298831	13/39 (33%)
		CA	692..772	CDD:214520	20/82 (24%)
		Cadherin_repeat	778..873	CDD:206637	14/98 (14%)
		Cadherin_repeat	882..994	CDD:206637	15/116 (13%)
		Cadherin_repeat	1015..1099	CDD:206637	5/12 (42%)
		Cadherin_repeat	1108..1207	CDD:206637
		Cadherin_repeat	1215..1314	CDD:206637
		Cadherin_repeat	1327..1427	CDD:206637
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
Cdhr1	NP_570948.1	Cadherin_repeat	42..130	CDD:206637	34/97 (35%)
		Cadherin_repeat	139..242	CDD:206637	28/113 (25%)
		Cadherin_repeat	251..350	CDD:206637	34/108 (31%)
		Cadherin_repeat	364..469	CDD:206637	39/106 (37%)
		Cadherin_repeat	478..573	CDD:206637	37/192 (19%)
		Cadherin_repeat	580..679	CDD:206637	40/195 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..838		9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010