Protein Alignment Cad87A and Cdh23

DIOPT Version :10

• Sequence 1: NP_731649.2
• Gene: Cad87A / 41441
• FlyBaseID: FBgn0037963
• Length: 1975
• Species: Drosophila melanogaster
• Sequence 2: XP_063134984.1
• Gene: Cdh23 / 114102
• RGDID: 619760
• Length: 3351
• Species: Rattus norvegicus
• Alignment Length: 2083
• Identity: 559/2083 - (26%)
• Similarity: 909/2083 - (43%)
• Gaps: 360/2083 - (17%)

  Fly    25 PVFT-QTLNNIILYENVTVGTVVFRLEAYD---PEGSPVTYGAI-GAD-HFSVDPVSGNITLIKP 83
            |||| |..|.:.|.|...:||.|..:.|.|   .:|..|.|..: ||: .|.:|..:|.|..:..
  Rat  1204 PVFTQQQYNRLGLRETAGIGTSVIVVRATDRDTGDGGLVNYRILSGAEGKFEIDESTGLIVTVDY 1268

  Fly    84 LDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLNDNPPEFQNTPYEADVNEDAAVG 148
            ||.|.|.:....||..|...|..:    ....|.:|  :|:..|...:|.|..|||.:.|:.|:|
  Rat  1269 LDYETKTSYLMNVSATDGAPPFNQ----GFCSVYVT--LLNELDEAVQFSNASYEAVIMENLALG 1327

  Fly   149 TTI--FDKITVKDRDIVGESLDLKCLPQQQSPEACRKFRLHIIKRDATILEAAVVLNDTLNYNQR 211
            |.|  ....::.:.:.:....|.....|.::          :.|.||  :...:.:...::..:.
  Rat  1328 TEIVRVQAYSIDNLNQITYRFDAYTSAQAKA----------LFKIDA--ITGVITVKGLVDREKG 1380

  Fly   212 MVYHFQIEATD-GPHKTQTTFEARVKDVQDKPPVFQGSLSTVID--EDSPINTLVLTVHARDGDT 273
            ..|...:.|.| ||....|.....|.|..|..|.|..:..:.|.  ||.|:...|.||.|||.|.
  Rat  1381 DFYTLTVVADDGGPKVDSTVVYVTVLDENDNSPRFDFTSDSAISVPEDCPVGQRVATVKARDPDA 1445

  Fly   274 GEPRKIVYDLRT----------NPNDYFLLDAQTGELRTAKPLDREALEDSTGIISLVIRARELV 328
            |...::|:.|.:          ..||      ..||:..|||||||.|:..  |:.:|...|
  Rat  1446 GSNGQVVFSLASGNIAGAFEIITSND------SIGEVFVAKPLDREELDHY--ILKIVASDR--- 1499

  Fly   329 NGVP---SDDPLTSATAKATVTIRDVNDSPPVFNHK-EYSVSLLENTLPGTPLALDMSVSDADVG 389
             |.|   .|..|       .|||.||||:|||.... .|:||:.||...||.: :.:..:|.|:|
  Rat  1500 -GTPPRKKDHIL-------QVTILDVNDNPPVIESPFGYNVSVNENVGGGTSV-VQVRATDRDIG 1555

  Fly   390 INS-----------KFALRLDDVSGVFDVEPKLVTGYSQVNIRVANGTLDYENPNQRKFIVLVVA 443
            |||           ....|:|.:||.....|               ...|.|..|   |..|||.
  Rat  1556 INSVLSYYITEGNEDMTFRMDRISGEIATRP---------------APPDRERQN---FYHLVVT 1602

  Fly   444 EETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVSEAA-LPGQYIATITARDVDSGSYGDS 507
            .|.:..|.||:|..:.|:::|.|||.|||:|..|...:.|.. .....:.|:.|.|:|.|..|.
  Rat  1603 VEDEGTPTLSATTHVYVTIVDENDNAPVFQQPHYEVVLDEGPDTVNTSLITVQALDLDEGPNGT- 1666

  Fly   508 GIRYSL-SGTGAELFHVNEQTGVISLANCHDNGESNRR--------------------------E 545
             :.|:: :|.....|.:|.:||||:.|...|...|:.|                          .
  Rat  1667 -VTYAIVAGNIINTFRINRRTGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVN 1730

  Fly   546 RRDLNEDEHVEEDDGEGHLEMLSME---------AATREIGTEPTVQYTLITQAPEEQASSVPLP 601
            ..|:|::......|.||..::...:         |..|:.|....|:|:::...|..:....|:.
  Rat  1731 VNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTFLAHDRDSGPNGQVEYSVVDGDPLGEFVISPVE 1795

  Fly   602 A------------------------------PVPHAAPSGVPAATAND---------------DK 621
            .                              |:......|:.....||               :.
  Rat  1796 GVLRVRKDVELDRETIAFYNLTICARDRGVPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISEN 1860

  Fly   622 APQTCL-------DYESETTYFLSYKATDDNG------RGSASVVS------------------- 654
            :|.:..       |.:|.....|::..|..|.      ..:..:|:
  Rat  1861 SPVSSFVAHVLASDADSGCNALLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYRLTVSV 1925

  Fly   655 ----------------LRISVTDANDSPPVCESPLYRASVDEGA------VVFDSPLIVKARDAD 697
                            |.:|:.|.||:.|:.....|:|.|.|.:      .|.:.|::....|.|
  Rat  1926 KDNPENPRIARKDFDLLLVSLADENDNHPLFTEGTYQAEVMENSPAGTPLTVLNGPILALDADED 1990

  Fly   698 TMSRISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTNLNSDQLIFAVEAND-GLFTAHCGVN 761
            ..:.::|::.|:.  ..:|.||..||.:.:|....:|....:...|...:.|.| |.......:.
  Rat  1991 VYAVVTYQLLGTH--SDLFVIDNSTGVVTVRSGVIIDREAFSPPFLELLLLAEDVGQLNGTAYLF 2053

  Fly   762 ITVRDVNNHVPNFEQQSYSAVVEENSEIGTSVERVHATDLDTGKNAELRYRIQQGSFDDFGIVET 826
            ||:.|.|::.|.|...:|:..:.||...|.||.::.|||.|:|.|.||.|||:.|:.|.|.|...
  Rat  2054 ITILDDNDNWPTFSPPAYTVHLLENCPPGFSVLQITATDEDSGLNGELVYRIEAGAQDRFLIHPV 2118

  Fly   827 TGEVFV-SRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRAD 890
            ||.:.| :..:|.:.:.:|:|.:.|:|:||..|:||||:||.:.:.||..|.|:...|...|...
  Rat  2119 TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTATVTILIDDINDSRPEFLNPIQTVSVLES 2183

  Fly   891 APPGQLVYTLIALDPDV---ANHNALEFAGTDDITAIDKEGKELPHYDQFKEYFKISRN-GKVSV 951
            ..||.::..:.|:|.|:   ..::.|.....||...:      :|  || ::.|.::.| |.|.|
  Rat  2184 TEPGTVIANVTAIDLDLNPKLEYHILSIVAKDDTDRL------VP--DQ-EDAFAVNINTGSVIV 2239

  Fly   952 NKQLDRNLFAVMRINVLVTDS---------TAPNVQQGRGLLIIQIIDVNKNPPRFNAPWSVEQP 1007
            ...|:|.|.|...:.:.|.|:         :.||.:     |.:.|:|||.|.|:|. |:.:  .
  Rat  2240 KSPLNRELVATYEVTLSVIDNASDLPERSVSVPNAK-----LTVNILDVNDNTPQFK-PFGI--T 2296

  Fly  1008 QIKLQMVEEQPVGTVLTTLQANDEDSSIG---EFNISD---NDYFAINQTS-GMIYTIARLDYEV 1065
            ....:::|....||.|..:.|.|.|..:.   .:.:.|   ..|..:..:| |.:.....:|||.
  Rat  2297 YYTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLIPPGYVQLEDSSAGKVIANRTVDYEE 2361

  Fly  1066 VKEVKFQVTVSDTGVPALTATADVVVDIINLNDNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDG 1130
            |..:.|.|..||.|.|...|...|.::|:::|||:|.|.|..|...|.|:...|||..:|.|.|.
  Rat  2362 VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQLSYQEAVFEDVAVGTVILRVTATDA 2426

  Fly  1131 DVGVFGEITYTLIGENNKYFSIDAYTGNVMVANSSILDREQIKELTLSVVAQDKA--PAAVQKSA 1193
            |.|.|..|.|:|:....| |:|:..||::.|.:|  ||||:.....|:.:|:|..  .|:.::..
  Rat  2427 DSGNFALIEYSLVDGEGK-FAINPNTGDIYVLSS--LDREKKDHYILTALAKDNPGDVASNRREN 2488

  Fly  1194 TATIHINILDVNDNAPVFTRDVYNSTVAENAAYQPPA--ALLQVQAIDQDEGLYGDVRYIITAGN 1256
            :..:.|.:|||||..|.|::..::::|.||    .||  :::.:.|.|||||..|.:.|.: .|.
  Rat  2489 SVQVVIRVLDVNDCRPQFSKPQFSTSVYEN----EPAGTSVITMLATDQDEGSNGQLTYSL-EGP 2548

  Fly  1257 EMGLFKLDAQSGIV---YPAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEF 1318
            .|..|.:|..||:|   .|.||    :..:.||:.|.| .|...:..||..::.|:.||.::|.|
  Rat  2549 GMEAFSVDMDSGLVTTQRPLQS----YERFNLTVVATD-GGEPPLWGTTMLLVEVIDVNDNRPVF 2608

  Fly  1319 VIPALSNATI-----EIP--GDIVQPDYLLLTVRAMDNDTEENGKVSYHL--QVNNRNEQQTGEF 1374
            |.|  .|.||     |||  .::.:       |.|.|.|...||.|.|..  ...||:.:.   |
  Rat  2609 VRP--PNGTILHIKEEIPLRSNVYE-------VYATDKDEGLNGAVRYSFLKSTGNRDWEY---F 2661

  Fly  1375 KIDEVTGELRAKTQLNRKNRANYDIILVARDAGNP-PFESLRLLSVSIVDANENRPEF---PDAS 1435
            .||.::|.::...:|:|:.:|.|.:||||.|.|.| |:|:::.|.|::.|.::|.|.|   |..|
  Rat  2662 TIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGS 2726

  Fly  1436 NPYK-VSINENSGRDVKIGHIQAASRSKH--NRDIFYYMLLGNEDGAFYVDKLTGDIYTNKSLDR 1497
            ..|: :::.|:|.|...:|::..|..:..  |..::|::..||||..|::.. .|.:...:.|||
  Rat  2727 PQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEDKNFHLQP-DGRLLVLRDLDR 2790

  Fly  1498 EETDVYTLYILASIKADLHISEEERASFSIKTLNRDNTVAKVAITVLDVNDNPPVFEKPIYYAGV 1562
            |...:::..:.||.............:..:.|   |.|:.:|.:.:.|:||.||.|.|..|.|||
  Rat  2791 ETEAIFSFIVKASSNRSWTPPRGPSPALDLLT---DLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2852

  Fly  1563 NANAKMGAAITLVNATDADQGKNAKIEFMIVASNLYKFGATKSTGSIVPSPFAI-SQDGRISANT 1626
            ..:||:|:.:..|.|.|||.|.|:.:.:.|:|  ::.|.|..:....|...|.: |.||.:....
  Rat  2853 ATDAKVGSELIQVLALDADIGNNSLVFYGILA--IHYFRALANDSEDVGQVFTMGSVDGILRTFD 2915

  Fly  1627 IMAEYNQDRFELEIVARELEQPQSSASTKVNIWVFDGTQLVRVILSRPPEEVYQEQEEIIAELRN 1691
            :...|:...|.::||||:|.....:|.  :.|::....|.|:::::..|:.|...:||.|..|.|
  Rat  2916 LFMAYSPGYFVVDIVARDLAGHNDTAI--IGIYILRDDQRVKIVINEIPDRVRGFEEEFIRLLSN 2978

  Fly  1692 ATQHRIIVDEIRFHLDSIGRIRMDWCDLYFHAVDPQTQQIAPVDEILKDIDRNYDYLKDYYAGFA 1756
            .|...:..|:::||:|..||:.....:|..|.|:..|.:|..||.:::.||.|.:.|::.:..:.
  Rat  2979 ITGAIVNTDDVQFHVDMKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYN 3043

  Fly  1757 IENVVPAYIAIVQDEFDLAVAGLVALVIVLFVGVISFIVLCCCLKHWNLSVPVETRRKEALIKK- 1820
            :.:|.||....:.|:.......::.|.|:||:..:.|:     |.:|.... :..|:.:|::..
  Rat  3044 VLDVQPAISVQLPDDMSALQMAIIVLAILLFLAAMLFV-----LMNWYYRT-IHKRKLKAIVAGS 3102

  Fly  1821 -------QIIEDLNTTE------NPLWIEQKLKLYEEQELTMQVFSE---PDHIS------NSEA 1863
                   .|::..||.:      ||:|::   ......||..|...|   |:::|      ||..
  Rat  3103 AGNRGFIDIMDMPNTNKYSFDGANPVWLD---PFCRNLELAAQAEHEDDLPENLSEIADLWNSPT 3164

  Fly  1864 PGH 1866
            ..|
  Rat  3165 RTH 3167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	27/99 (27%)
		Cadherin_repeat	136..240	CDD:206637	21/106 (20%)
		Cadherin_repeat	248..353	CDD:206637	38/119 (32%)
		Cadherin_repeat	362..468	CDD:206637	33/116 (28%)
		Cadherin_repeat	476..>533	CDD:206637	16/58 (28%)
		CA_like	<627..667	CDD:481204	11/87 (13%)
		CA	692..772	CDD:214520	19/80 (24%)
		Cadherin_repeat	778..873	CDD:206637	38/95 (40%)
		Cadherin_repeat	882..994	CDD:206637	31/124 (25%)
		Cadherin_repeat	1015..1099	CDD:206637	25/90 (28%)
		Cadherin_repeat	1108..1207	CDD:206637	35/100 (35%)
		Cadherin_repeat	1215..1314	CDD:206637	33/103 (32%)
		Cadherin_repeat	1327..1427	CDD:206637	35/109 (32%)
		Cadherin_repeat	1437..1549	CDD:206637	26/114 (23%)
		Cadherin_repeat	1557..1662	CDD:206637	32/105 (30%)
Cdh23	XP_063134984.1	None