DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad87A and CDH16

DIOPT Version :10

Sequence 1:NP_731649.2 Gene:Cad87A / 41441 FlyBaseID:FBgn0037963 Length:1975 Species:Drosophila melanogaster
Sequence 2:NP_004053.1 Gene:CDH16 / 1014 HGNCID:1755 Length:829 Species:Homo sapiens


Alignment Length:725 Identity:164/725 - (22%)
Similarity:264/725 - (36%) Gaps:156/725 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   802 DTGKNAELRYRIQQGSFDDFGIVETTGEVFVSRKLDFDRRNTYQLQIQASDQGTPSLTGTATLTI 866
            |:||..|          ..|.:...:|.:.|:|.||.:.:..||||:....|....|.|...:.:
Human    60 DSGKATE----------GPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLV 114

  Fly   867 NVQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLIALD---PDVANHNALEFAGTDDITAIDKEG 928
            :|::.||:.|:|..|...|.:.....||.....|.|.|   |..||.: |.|       .|..:.
Human   115 HVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSD-LRF-------HILSQA 171

  Fly   929 KELPHYDQFK-----EYFKISRNGKVSVNKQLDRNLFAVMRINVLVTDSTAPNVQQGRGLLIIQI 988
            ...|..|.|:     ....:|..|..|::..|:|..                       .|::|:
Human   172 PAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTY-----------------------QLLVQV 213

  Fly   989 IDVNKNPPRFNAPWSVEQPQIKLQMVEEQPV---------------------GTVLTTLQANDED 1032
            .|:........|..:||...|:...|..:|:                     |.|...|:::.. 
Human   214 KDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPP- 277

  Fly  1033 SSIGEFNISDNDYFAINQTSGMIYTIARLDYEVVKEVKFQVTVSDTGVPALTATADVVVDIINLN 1097
               |.|.::         ..|.:|....||.|...|...||...::......|..::.|.:::.|
Human   278 ---GPFEVN---------AEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDEN 330

  Fly  1098 DNDPKFSQSDYYFNVTENSPRGTVAGKVEAHDGDV--GVFGEITYTLI------GENNKYFSIDA 1154
            ||.|.....|...::.|.||.||...::.|.|.|.  .....:.|.|:      |...:.|.:|.
Human   331 DNVPICPPRDPTVSIPELSPPGTEVTRLSAEDADAPGSPNSHVVYQLLSPEPEDGVEGRAFQVDP 395

  Fly  1155 YTGNVMVANSSILDREQIKELTLSVVAQDKAPAAVQKSATATIHINILDVNDNAPVF-TRDVYNS 1218
            .:|:|.:   .:|.....:.:.|.|:|.|.|.|....|:|..:.:.:.|:||:||.| |..:...
Human   396 TSGSVTL---GVLPLRAGQNILLLVLAMDLAGAEGGFSSTCEVEVAVTDINDHAPEFITSQIGPI 457

  Fly  1219 TVAENAAYQPPAALLQVQAIDQD-EGLYGDVRYIITAGNEMGLFKLD--AQSGIV---------Y 1271
            ::.|:.  :|...:..:.|||.| |..:..:.:.|..|:..|.|.||  ..||.|         |
Human   458 SLPEDV--EPGTLVAMLTAIDADLEPAFRLMDFAIERGDTEGTFGLDWEPDSGHVRLRLCKNLSY 520

  Fly  1272 PAQSLSGKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIEIPGDIVQ 1336
            .|   :..|....:..|.....|.|.....| |.:||| |.|..|.   |.|...:.|....|..
Human   521 EA---APSHEVVVVVQSVAKLVGPGPGPGAT-ATVTVL-VERVMPP---PKLDQESYEASVPISA 577

  Fly  1337 P-DYLLLTVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNRAN-YDI 1399
            | ...|||::..|       .:|..|:.:..|:.: |...|::.:||:.....|......: |.:
Human   578 PAGSFLLTIQPSD-------PISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPGDTYTV 634

  Fly  1400 ILVARDAGN----------------PPFESLRLLSVS-------------IVDANENRPEFPDAS 1435
            ::.|:|...                ||..:|.|..|.             ||......|:.....
Human   635 LVEAQDTDEPRLSASAPLVIHFLKAPPAPALTLAPVPSQYLCTPRQDHGLIVSGPSKDPDLASGH 699

  Fly  1436 NPYKVSINEN 1445
            .||..::..|
Human   700 GPYSFTLGPN 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad87ANP_731649.2 Cadherin_repeat 33..128 CDD:206637
Cadherin_repeat 136..240 CDD:206637
Cadherin_repeat 248..353 CDD:206637
Cadherin_repeat 362..468 CDD:206637
Cadherin_repeat 476..>533 CDD:206637
CA_like <627..667 CDD:481204
CA 692..772 CDD:214520
Cadherin_repeat 778..873 CDD:206637 18/70 (26%)
Cadherin_repeat 882..994 CDD:206637 23/119 (19%)
Cadherin_repeat 1015..1099 CDD:206637 17/104 (16%)
Cadherin_repeat 1108..1207 CDD:206637 26/106 (25%)
Cadherin_repeat 1215..1314 CDD:206637 28/110 (25%)
Cadherin_repeat 1327..1427 CDD:206637 25/130 (19%)
Cadherin_repeat 1437..1549 CDD:206637 3/9 (33%)
Cadherin_repeat 1557..1662 CDD:206637
CDH16NP_004053.1 CA 47..124 CDD:214520 20/73 (27%)
Cadherin_repeat 130..234 CDD:206637 26/134 (19%)
Cadherin_repeat <264..332 CDD:206637 16/80 (20%)
Cadherin_repeat 342..445 CDD:206637 26/105 (25%)
Cadherin_repeat 457..558 CDD:206637 28/107 (26%)
Cadherin_repeat 568..655 CDD:206637 18/94 (19%)
Ectodomain G 666..786 8/44 (18%)
Blue background indicates that the domain is not in the aligned region.

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