DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad87A and cdhr2

DIOPT Version :9

Sequence 1:	NP_731649.2	Gene:	Cad87A / 41441	FlyBaseID:	FBgn0037963	Length:	1975	Species:	Drosophila melanogaster
Sequence 2:	XP_017214654.2	Gene:	cdhr2 / 100536704	ZFINID:	ZDB-GENE-190529-1	Length:	1301	Species:	Danio rerio

Alignment Length:	1520	Identity:	373/1520 - (24%)
Similarity:	583/1520 - (38%)	Gaps:	342/1520 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLPLGLLMICLGLTLAKGETN-LPPVFTQTLNNIILYENVTVGTVVFRLEAYDPEGSPVTYGAI 64
            |:.|| ||:..:   ||.|..| ||.:.|..   :||.|::.:|...|::.|.||:..|:||...
Zfish     1 MEKPL-LLLFSI---LASGYCNELPEISTSV---VILREDLRIGEYAFKIVATDPDDDPLTYKIA 58

  Fly    65 G--ADHFSVDPVSGNITLIKPLDREEKDTLKFLVSIRDRVDPEGESERDNVVEVPITFIILDLND 127
            |  |..|:|:..:|.:|:...||||..|.:.....:.|.|..:        |...|...:.|.||
Zfish    59 GTNAGFFTVEEHTGIVTIKILLDRETNDIMNIDAIVNDGVYDD--------VRKTIYINVEDAND 115

  Fly   128 NPPEFQNTPYEADVNEDAAVGTTIFDKITVKDRD-----IVGESLDLKCLPQQQSPEACRKFRLH 187
            |.|.|...||..:|.|:..||..:| ..:..|.|     ||...:| :.:|..
Zfish   116 NIPIFNGLPYNKEVLENTTVGFVLF-TASATDSDFGQAGIVSYKID-EVVPDD------------ 166

  Fly   188 IIKRDATILEAA---VVLNDTLNYNQRM-VYHFQIEATDG---------PHKTQTTFEARVKDVQ 239
               :|...:.||   |.|...||:.::. .|..:|.|:||         ...:.......||||.
Zfish   167 ---KDMFSIVAATGVVTLVGNLNFTEKSPFYQIRINASDGGGELYGEEVVQSSSAIAFITVKDVP 228

  Fly   240 DKPPVFQG-SLSTVIDEDSPINTLVLTVHARDGDTGEPRKIVYDL-RTNPNDYFLLDAQTGELRT 302
            |..|.|.. ..:..::|::.:.|.|.||.|||.|||...||.:.: :||.:|.|.:|..||.:..
Zfish   229 DIDPQFLNLPNNAAVEENTGVGTTVFTVRARDPDTGVNDKITFSIDKTNASDLFRIDTNTGIVSV 293

  Fly   303 AKPLDREALEDSTGIISLVIRAREL---VNGVPSDDPLTSATAKATVTIRDVNDSPPVFNHKEYS 364
            ...:|||.|.:.:..:.|.|:|.|.   ||||     :.|...:..::|:|.||:.|.|...|..
Zfish   294 NAEIDREELLNISATVVLKIKASETMPNVNGV-----IASTIGELQISIKDENDNSPEFYECEGE 353

  Fly   365 VSLLENTLPG-------TPLA---LDMSVSDADVGINSKFALRLDDV-SGVFDVEPKLVTGYSQV 418
            ..:.::...|       |.||   |::.|.|.|.|.||.|.|.||.. ...|.|.|....|.|.|
Zfish   354 ACMKKDNFEGNVNEHSSTGLAVANLNIKVKDLDGGENSTFNLHLDGPDKDAFRVSPTSGMGESTV 418

  Fly   419 NIRVAN-GTLDYENPNQRKFIVLVVAEETDTNPRLSSTATITVSVLDANDNKPVFEQESYSASVS 482
            .:.|.: ..:|||    .|.|:.|.....|.|...:||||:|:.:.|.|||.|.||:|.|...|.
Zfish   419 QVLVKDPQAVDYE----IKQIMNVQIIAVDANADFTSTATVTIHLNDTNDNFPTFEKELYKEKVF 479

  Fly   483 EAALPGQYIATITARDVDSGSYGDSGIRYSLSGTG-AELFHVNEQTGVISLANCHDNGESNRRER 546
            |....|..:|||.|.|.|  ::.:..|.|.|.... ..||.|:|:||.|.:.    ||::
Zfish   480 EHCENGTIVATIIATDAD--AFDEGKITYRLMPESIRSLFGVHEKTGTIYVT----NGDT----- 533

  Fly   547 RDLNEDEHVEEDDGEGHLEMLSMEAATREIGTEPTVQYTLITQAPEEQASSVPLPAPVPHAAPSG 611

Zfish   534 ----------------------------------------------------------------- 533

  Fly   612 VPAATANDDKAPQTCLDYESETTYFLSYKATDDNGRGSASVVSLRISVTDANDSPPVCESPLYRA 676
                           ||:|...:|.|:.:|.|.......:||  .||:.|.||:.|.....:|.|
Zfish   534 ---------------LDWEVTKSYTLTLQAFDSGNNTGTTVV--EISILDINDNAPEMNRDIYEA 581

  Fly   677 SVDEGAVVFDSPLIVKARDAD---TM-SRISYRIRGSEQVESIFDIDRETGQIIIRPNATLDVTN 737
            .|.|..   |..:.::|.|.|   |: |.:.|||.......|.|.|..|:|.:..:.:...:..:
Zfish   582 FVQENE---DFKIQIQATDRDEPKTLNSEVQYRISEESTFSSNFTIGLESGLLTNKGDLDREAID 643

  Fly   738 LNSDQLIFAVEANDGLFT----AHCGVNITVRDVNNHVPNF-EQQSYSAVVEENSEIGTSVERVH 797
            ::.:.:|..:.....|.|    :...|||:|.|.|::.|.: :...|...|:|:.: |..|..||
Zfish   644 ISQNGVIQLIVIASDLGTPSRSSSAKVNISVGDANDNAPRYLDSSPYEFRVKESVK-GIYVGPVH 707

  Fly   798 ATDLD-TGKNAELRYRIQQGSFDDFGIVETT------GEVFV--SRKLDFD-RRNTYQLQIQASD 852
            |.|.| |..|..:.:.|..|||..|.|....      |.:.|  |.:||:: .|..|.|::||||
Zfish   708 AHDADQTDFNNRIFFSITDGSFGSFIIYSEAFSKGYRGNITVDPSVELDYESNRKEYTLKVQASD 772

  Fly   853 QGTPSLTGTATLTINVQNSNDKDPYFVPATQHAEVRADAPPGQLVYTLIALDPDVANHNAL-EFA 916
            .|..|  ..|.:.|.|::.||..|.| |:....:|..:......|.|:...|.| .||:.: |..
Zfish   773 LGQKS--DVAEVHIIVEDVNDTPPEF-PSGMILKVDENTTLPVPVDTIKGKDVD-TNHSLIYELV 833

  Fly   917 GTDDITAIDKEGKELPHYDQFKEYFKISRNGKVSVNKQ--LDRNLFAVMRINVLVTD-STAPNVQ 978
            .    |.....|...|..:   |:|.:..||.:..|.:  :|.....|:.:...|.| .|.....
Zfish   834 S----TKCQCNGTIGPCPE---EWFIVESNGDIIANTEYVIDYEKCDVVFLTARVVDIYTEVGSN 891

  Fly   979 QGRGLLIIQIIDVNKNPPRFNAPWSVEQPQIKLQMVEEQPVGTVLTTLQANDEDSSIGEFNISDN 1043
            ...|::.|.|:|:|.|.|.|     |......:.::|:...||.:....|.|.|:       :||
Zfish   892 SSEGVVTINIVDINDNAPEF-----VFLQDFYVVVIEKVDTGTSVARAYATDRDT-------ADN 944

  Fly  1044 DYFAINQTSGMIYTIARLDYEVVKEVKFQVT----VSDTGVPALTATADVVVDIINLNDNDPKFS 1104
            :                      |:.||||.    :...|    ..|..:.:...|.:..|.:..
Zfish   945 N----------------------KKTKFQVNKITFIGSEG----NTTESLFLYADNFDQEDAEGR 983

  Fly  1105 QSDYYFN--VTENSPRGTVAGKVEAHDGDVGVFGEITYTLIGENNKYFSIDAYTGNVMVANSSI- 1166
            .:.|..:  ..:|:.||....:|||.:|.:...|.:                   .::..:||.
Zfish   984 YTAYIRSQKAMDNNKRGKFMVEVEAVNGKLSTTGVV-------------------ELLTVDSSFR 1029

  Fly  1167 ----LDR--EQIKELTLSVVAQDKAPAAVQKSATATIHI-NILDVNDNAPVFTRDVYNSTVAENA 1224
                .||  .::.|      |..:....:|.:..|.:.| |:...:.|     :.....|:.|..
Zfish  1030 VSLRFDRTVAEVNE------ALPQVRGILQSATKAMVEIFNVFSDSGN-----QRAEEKTILEAY 1083

  Fly  1225 AYQPPAALLQVQAID---QDEGLY-------GDVRY--IITAGNEMGLFKLDAQSGIVYPAQSLS 1277
            ...|..:.|...|:.   ..|.:|       |.:.:  |.|.||:        .:|:......:.
Zfish  1084 FVFPNGSALDYDAVTSILNSEEVYKEFGQQLGQLGFTGISTTGND--------PTGVKTEVYIMI 1140

  Fly  1278 GKHGAYELTISARDTQGSGTMESTTKAIITVLRVNRHKPEFVIPALSNATIEIPGDIVQPDYLLL 1342
            |...|..:.:..           .|.:::.:.|..:.|.:......|.||:.|......|
Zfish  1141 GLMAALAIVLVV-----------MTTSLVCIRRNYKRKLKASKAMNSAATVVIQNQKSGP----- 1189

  Fly  1343 TVRAMDNDTEENGKVSYHLQVNNRNEQQTGEFKIDEVTGELRAKTQLNRKNRANYDIILVARDAG 1407
            .|...:..|:|...     .|.|.|.....:...|| .|....:..|   |..:|:|.:...:..
Zfish  1190 VVPGTNKYTKEGAN-----PVLNMNIDTATDLGFDE-DGSSADRESL---NSLDYNIDMAMAEKD 1245

  Fly  1408 NPPFESLRLLSVSIVDANENRPEFP 1432
            |.|..:::    ...:.:|.|.|.|
Zfish  1246 NMPMMAIQ----EEEEEDEERSESP 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad87A	NP_731649.2	Cadherin_repeat	33..128	CDD:206637	28/96 (29%)
		Cadherin_repeat	136..240	CDD:206637	29/121 (24%)
		Cadherin_repeat	248..353	CDD:206637	35/108 (32%)
		Cadherin_repeat	362..468	CDD:206637	38/117 (32%)
		Cadherin_repeat	476..>533	CDD:206637	20/57 (35%)
		E_set	<627..667	CDD:298831	14/39 (36%)
		CA	692..772	CDD:214520	22/87 (25%)
		Cadherin_repeat	778..873	CDD:206637	35/104 (34%)
		Cadherin_repeat	882..994	CDD:206637	26/115 (23%)
		Cadherin_repeat	1015..1099	CDD:206637	16/87 (18%)
		Cadherin_repeat	1108..1207	CDD:206637	19/108 (18%)
		Cadherin_repeat	1215..1314	CDD:206637	17/110 (15%)
		Cadherin_repeat	1327..1427	CDD:206637	18/99 (18%)
		Cadherin_repeat	1437..1549	CDD:206637
		Cadherin_repeat	1557..1662	CDD:206637
cdhr2	XP_017214654.2	Cadherin_repeat	27..116	CDD:206637	28/99 (28%)
		Cadherin_repeat	124..229	CDD:206637	29/121 (24%)
		Cadherin_repeat	240..343	CDD:206637	36/107 (34%)
		Cadherin_repeat	361..465	CDD:206637	37/107 (35%)
		Cadherin_repeat	474..570	CDD:206637	35/188 (19%)
		Cadherin_repeat	578..680	CDD:206637	27/104 (26%)
		Cadherin_repeat	689..791	CDD:206637	35/104 (34%)
		CA	820..909	CDD:214520	24/96 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910