DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAT2A and Sam-S

DIOPT Version :9

Sequence 1:	NP_005902.1	Gene:	MAT2A / 4144	HGNCID:	6904	Length:	395	Species:	Homo sapiens
Sequence 2:	NP_524923.1	Gene:	Sam-S / 48552	FlyBaseID:	FBgn0005278	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	287/394 - (72%)
Similarity:	344/394 - (87%)	Gaps:	3/394 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     2 NGQLNGFHEAFIEEG-TFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMI 65
            ||.....::  :|:| ||||||||||||||||:|||||||:|||||:|||:||||||||||||||
  Fly    14 NGSNGNSYD--MEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMI 76

Human    66 LLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDI 130
            ||.|||||:|.|||||||||.|:||||||||||||:||.|:|||:|||||:||.|||::|.|||:
  Fly    77 LLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDWKTLNLLVAIEQQSPNIANGVHINREEEDV 141

Human   131 GAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAV 195
            ||||||:||||||||||||||||:|||||||.|:|||||:....|.|||||||||.:|:.::|:.
  Fly   142 GAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSA 206

Human   196 LPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAG 260
            :|.||||||:|:||.|::.|:.:|..:.|||:|.|:||||:|.:||.|:.|.|.||||||.||||
  Fly   207 VPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAG 271

Human   261 LTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVS 325
            ||||||||||||||||||||||||||:||||||||||||||||||||.|||:|.|||||||||::
  Fly   272 LTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLA 336

Human   326 HPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVP 390
            .||||::|.||||.||::|||:|:::|||||||.||:||:|::||||||:.||||||..|.||..
  Fly   337 EPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEA 401

Human   391 KKLK 394
            |.|:
  Fly   402 KPLE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAT2A	NP_005902.1	PTZ00104	16..395	CDD:240268	284/380 (75%)
MAT2A	NP_005902.1	Flexible loop. /evidence=ECO:0000250\|UniProtKB:P0A817	113..125		8/11 (73%)
Sam-S	NP_524923.1	PTZ00104	28..408	CDD:240268	283/378 (75%)
		S-AdoMet_synt_N	28..125	CDD:278846	83/96 (86%)
		S-AdoMet_synt_M	140..261	CDD:280867	76/120 (63%)
		S-AdoMet_synt_C	263..399	CDD:280868	107/135 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147328
Domainoid	1	1.000	240	1.000	Domainoid score	I2265
eggNOG	1	0.900	-	-		E1_COG0192
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38112
Inparanoid	1	1.050	606	1.000	Inparanoid score	I937
Isobase	1	0.950	-	0	Normalized mean entropy	S107
OMA	1	1.010	-	-		QHG61243
OrthoDB	1	1.010	-	-		D357186at33208
OrthoFinder	1	1.000	-	-		FOG0000746
OrthoInspector	1	1.000	-	-		otm41944
orthoMCL	1	0.900	-	-		OOG6_100388
Panther	1	1.100	-	-	LDO	PTHR11964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R708
SonicParanoid	1	1.000	-	-		X478
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750