DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl5 and ADGRE5

DIOPT Version :10

Sequence 1:NP_001287291.1 Gene:mthl5 / 41438 FlyBaseID:FBgn0037960 Length:497 Species:Drosophila melanogaster
Sequence 2:NP_510966.1 Gene:ADGRE5 / 976 HGNCID:1711 Length:835 Species:Homo sapiens


Alignment Length:492 Identity:101/492 - (20%)
Similarity:180/492 - (36%) Gaps:135/492 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 NPLPVTSHVTSAGSSTALSSDPNLVLVNKCCEKFEIHVDHECQ----QVNETDYFQPMFTSYGG- 96
            :|.|..:.:.|..:.|.|.::.:|.|.:|  ::.|:...:|..    |:........:|.|:.. 
Human   393 DPGPAVAGILSIQNMTTLLANASLNLHSK--KQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNT 455

  Fly    97 -EQNRPVKFKFVIGIPNCGSMQMWPIYHYAGSSDKLVLLDDGRLRHYTNAENEAEERHGIQSDYE 160
             |.|.|:.|.|                                 .|..:::.||    |.....:
Human   456 KELNSPILFAF---------------------------------SHLESSDGEA----GRDPPAK 483

  Fly   161 EDIAGSLEPLY-----HDYDKGLYCIDKATSSTGEEN----------VLFANICLARKEIK-WSD 209
            :.:.|..:.|.     .|.|:|.:...:.....|.:|          ..|| |.:|..::: |..
Human   484 DVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFA-ILMAHYDVEDWKL 547

  Fly   210 SNFLLRKILNPIFHGISL-VILLVIAIIYFILPTLSRDLVGNIVTT---IAMCLMVSQAADLVRI 270
            :  |:.::      |::| :..|::.|:.|:   |.|.:.|:..|.   :.:||.|.....|..|
Human   548 T--LITRV------GLALSLFCLLLCILTFL---LVRPIQGSRTTIHLHLCICLFVGSTIFLAGI 601

  Fly   271 FTELTSHVSF---IVADII-LCFSLLAAFFWLNSFG----FYIWKTFRSRNVFLRVTDGRKYCYY 327
            ..| ...|..   :||.:: .||  ||||.|::..|    |.:.:.|:.:.:..|          
Human   602 ENE-GGQVGLRCRLVAGLLHYCF--LAAFCWMSLEGLELYFLVVRVFQGQGLSTR---------- 653

  Fly   328 SAYAWGCT----ATMAALAVFAHFFLDAESYKQEHMVGEQETIGWLG-----ICIFFAPIACTIL 383
                |.|.    ..:..:.|.|..:  ::.|.:....       ||.     :..|..|:...||
Human   654 ----WLCLIGYGVPLLIVGVSAAIY--SKGYGRPRYC-------WLDFEQGFLWSFLGPVTFIIL 705

  Fly   384 VNIFFYVTT-RKLINRRTVYGRIAHKLKANFIMFSLMLLVMSIAWLFLI-MSWL--------QME 438
            .|...:||| .||..:.:.......|||.     :..|.:.:||.|||: .:|:        :..
Human   706 CNAVIFVTTVWKLTQKFSEINPDMKKLKK-----ARALTITAIAQLFLLGCTWVFGLFIFDDRSL 765

  Fly   439 GLLYAHIVVNALQTPLLLYICVLRQRHVTFLLKKTCC 475
            .|.|...::|.||...|..:..|..:.|....:|..|
Human   766 VLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWAC 802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl5NP_001287291.1 7tmB3_Methuselah-like 215..474 CDD:410632 65/289 (22%)
TM helix 1 215..239 CDD:410632 4/24 (17%)
TM helix 2 249..271 CDD:410632 6/24 (25%)
TM helix 3 281..308 CDD:410632 11/31 (35%)
TM helix 4 324..344 CDD:410632 2/23 (9%)
TM helix 5 371..396 CDD:410632 9/25 (36%)
TM helix 6 409..435 CDD:410632 8/26 (31%)
TM helix 7 438..463 CDD:410632 7/24 (29%)
ADGRE5NP_510966.1 EGF_CA 64..96 CDD:429571
EGF_CA 116..>148 CDD:214542
EGF_CA 160..191 CDD:429571
EGF_CA 209..240 CDD:429571
GPS 494..536 CDD:460350 7/42 (17%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 495..543 9/48 (19%)
7tmB2_CD97 544..806 CDD:320554 68/301 (23%)
TM helix 1 546..571 CDD:320554 6/35 (17%)
TM helix 2 580..602 CDD:320554 5/21 (24%)
TM helix 3 613..640 CDD:320554 10/28 (36%)
TM helix 4 652..672 CDD:320554 4/33 (12%)
TM helix 5 689..718 CDD:320554 8/28 (29%)
TM helix 6 734..761 CDD:320554 7/31 (23%)
TM helix 7 765..790 CDD:320554 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..835
Blue background indicates that the domain is not in the aligned region.

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